ID   PAX_I47A0               Reviewed;         252 AA.
AC   P0CK88;
DT   03-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 1.
DT   08-NOV-2023, entry version 23.
DE   RecName: Full=Protein PA-X;
GN   Name=PA;
OS   Influenza A virus (strain A/Fort Monmouth/1/1947 H1N1).
OC   Viruses; Riboviria; Orthornavirae; Negarnaviricota; Polyploviricotina;
OC   Insthoviricetes; Articulavirales; Orthomyxoviridae; Alphainfluenzavirus;
OC   Alphainfluenzavirus influenzae; Influenza A virus.
OX   NCBI_TaxID=380282;
OH   NCBI_TaxID=8782; Aves.
OH   NCBI_TaxID=9606; Homo sapiens (Human).
OH   NCBI_TaxID=9823; Sus scrofa (Pig).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX   PubMed=8879138; DOI=10.1016/0168-1702(96)01329-9;
RA   Smeenk C.A., Wright K.E., Burns B.F., Thaker A.J., Brown E.G.;
RT   "Mutations in the hemagglutinin and matrix genes of a virulent influenza
RT   virus variant, A/FM/1/47-MA, control different stages in pathogenesis.";
RL   Virus Res. 44:79-95(1996).
CC   -!- FUNCTION: May play a role in the modulation of host immune response.
CC       {ECO:0000250}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Ribosomal frameshifting; Named isoforms=2;
CC       Name=PA-X;
CC         IsoId=P0CK88-1; Sequence=Displayed;
CC       Name=PA;
CC         IsoId=Q82570-1; Sequence=External;
CC   -!- SIMILARITY: Belongs to the influenza viruses PA-X family.
CC       {ECO:0000305}.
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DR   EMBL; X99039; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   EMBL; AJ238020; -; NOT_ANNOTATED_CDS; Genomic_RNA.
DR   SMR; P0CK88; -.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0039694; P:viral RNA genome replication; IEA:InterPro.
DR   Gene3D; 3.40.91.90; Influenza RNA-dependent RNA polymerase subunit PA, endonuclease domain; 1.
DR   InterPro; IPR001009; PA/PA-X.
DR   InterPro; IPR038372; PA/PA-X_sf.
DR   Pfam; PF00603; Flu_PA; 1.
PE   3: Inferred from homology;
KW   Ribosomal frameshifting.
FT   CHAIN           1..252
FT                   /note="Protein PA-X"
FT                   /id="PRO_0000419371"
FT   REGION          202..221
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        206..221
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   252 AA;  29507 MW;  02DDC2A1727C6B28 CRC64;
     MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINEQGRS
     IIVELGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKEDRFIEI
     GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ
     EMASRGLWDS FVNPREAKRQ LKKNLKSQEQ CATSPTKVSR RTSPALRILE PMWMDSNRTA
     TLRASFLKCP KK
//