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P0CK68 (PAX_I18A0) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 6. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Protein attributes

Sequence length252 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May play a role in the modulation of host immune response. Ref.2

Sequence similarities

Belongs to the influenza viruses PA-X family.

Ontologies

Keywords
   Coding sequence diversityRibosomal frameshifting
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processtranscription, DNA-templated

Inferred from electronic annotation. Source: InterPro

   Molecular_functionRNA binding

Inferred from electronic annotation. Source: InterPro

RNA-directed RNA polymerase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]
Isoform PA-X (identifier: P0CK68-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform PA (identifier: Q3HM39-1)

The sequence of this isoform can be found in the external entry Q3HM39.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 252252Protein PA-X
PRO_0000419351

Sequences

Sequence LengthMass (Da)Tools
Isoform PA-X [UniParc].

Last modified October 3, 2012. Version 1.
Checksum: 7D318D48B6267FDE

FASTA25229,378
        10         20         30         40         50         60 
MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINERGES 

        70         80         90        100        110        120 
IIVESGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKENRFIEI 

       130        140        150        160        170        180 
GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ 

       190        200        210        220        230        240 
EMASRGLWDS FVSPREAKRQ LKKDLKSQEQ CAGLPTKVSH RTSPALKTLE PMWMDSNRTA 

       250 
TLRASFLKCP KK 

« Hide

Isoform PA [UniParc].

See Q3HM39.

References

[1]"Characterization of the 1918 influenza virus polymerase genes."
Taubenberger J.K., Reid A.H., Lourens R.M., Wang R., Jin G., Fanning T.G.
Nature 437:889-893(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"An overlapping protein-coding region in influenza A virus segment 3 modulates the host response."
Jagger B.W., Wise H.M., Kash J.C., Walters K.A., Wills N.M., Xiao Y.L., Dunfee R.L., Schwartzman L.M., Ozinsky A., Bell G.L., Dalton R.M., Lo A., Efstathiou S., Atkins J.F., Firth A.E., Taubenberger J.K., Digard P.
Science 337:199-204(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
DQ208311 mRNA. No translation available.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

InterProIPR001009. RNA-dir_pol_influenzavirus.
[Graphical view]
PfamPF00603. Flu_PA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePAX_I18A0
AccessionPrimary (citable) accession number: P0CK68
Entry history
Integrated into UniProtKB/Swiss-Prot: October 3, 2012
Last sequence update: October 3, 2012
Last modified: April 16, 2014
This is version 6 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families