P0CK68 (PAX_I18A0) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein PA-X

Gene names

Name:

PA

Organism

Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1)) [Complete proteome]

Taxonomic identifier

88776 [NCBI]

Taxonomic lineage

Viruses › ssRNA viruses › ssRNA negative-strand viruses › Orthomyxoviridae › Influenzavirus A › Influenza A virus › H1N1 subtype

Virus host

Aves [TaxID: 8782]
Homo sapiens (Human) [TaxID: 9606]
Sus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length	252 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May play a role in the modulation of host immune response. Ref.2
Sequence similarities	Belongs to the influenza viruses PA-X family.

Ontologies

Keywords
Coding sequence diversity	Ribosomal frameshifting
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	transcription, DNA-dependent Inferred from electronic annotation. Source: InterPro
Molecular_function	RNA binding Inferred from electronic annotation. Source: InterPro RNA-directed RNA polymerase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by ribosomal frameshifting. [Align] [Select]

Isoform PA-X (identifier: P0CK68-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform PA (identifier: Q3HM39-1)

The sequence of this isoform can be found in the external entry Q3HM39.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 252	252	Protein PA-X		PRO_0000419351

Sequences

	Sequence		Length	Mass (Da)
	Isoform PA-X [UniParc]. Last modified October 3, 2012. Version 1. Checksum: 7D318D48B6267FDE	FASTA	252	29,378
	10 20 30 40 50 60 MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD FHFINERGES 70 80 90 100 110 120 IIVESGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA EKPKFLPDLY DYKENRFIEI 130 140 150 160 170 180 GVTRREVHIY YLEKANKIKS EKTHIHIFSF TGEEMATKAD YTLDEESRAR IKTRLFTIRQ 190 200 210 220 230 240 EMASRGLWDS FVSPREAKRQ LKKDLKSQEQ CAGLPTKVSH RTSPALKTLE PMWMDSNRTA 250 TLRASFLKCP KK
	Isoform PA [UniParc]. See Q3HM39.		–	–

References

[1]

"Characterization of the 1918 influenza virus polymerase genes." Taubenberger J.K., Reid A.H., Lourens R.M., Wang R., Jin G., Fanning T.G. Nature 437:889-893(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].

[2]

"An overlapping protein-coding region in influenza A virus segment 3 modulates the host response." Jagger B.W., Wise H.M., Kash J.C., Walters K.A., Wills N.M., Xiao Y.L., Dunfee R.L., Schwartzman L.M., Ozinsky A., Bell G.L., Dalton R.M., Lo A., Efstathiou S., Atkins J.F., Firth A.E., Taubenberger J.K., Digard P. Science 337:199-204(2012) [PubMed] [Europe PMC] [Abstract] Cited for: CHARACTERIZATION, FUNCTION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	DQ208311 mRNA. No translation available.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001009. RNA-dir_pol_influenzavirus. [Graphical view]
Pfam	PF00603. Flu_PA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PAX_I18A0

Accession

Primary (citable) accession number: P0CK68

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 3, 2012
Last sequence update:	October 3, 2012
Last modified:	November 28, 2012
This is version 3 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Viral Protein Annotation Program