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P0CK68

- PAX_I18A0

UniProt

P0CK68 - PAX_I18A0

Protein

Protein PA-X

Gene

PA

Organism
Influenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 7 (01 Oct 2014)
      Sequence version 1 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    May play a role in the modulation of host immune response.1 Publication

    GO - Molecular functioni

    1. RNA binding Source: InterPro
    2. RNA-directed RNA polymerase activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: InterPro

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein PA-X
    Gene namesi
    Name:PA
    OrganismiInfluenza A virus (strain A/Brevig Mission/1/1918 H1N1) (Influenza A virus (strain A/South Carolina/1/1918 H1N1))
    Taxonomic identifieri88776 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesOrthomyxoviridaeInfluenzavirus A
    Virus hostiAves [TaxID: 8782]
    Homo sapiens (Human) [TaxID: 9606]
    Sus scrofa (Pig) [TaxID: 9823]
    ProteomesiUP000008430: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 252252Protein PA-XPRO_0000419351Add
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the influenza viruses PA-X family.Curated

    Family and domain databases

    InterProiIPR001009. RNA-dir_pol_influenzavirus.
    [Graphical view]
    PfamiPF00603. Flu_PA. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by ribosomal frameshifting. Align

    Isoform PA-X (identifier: P0CK68-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MEDFVRQCFN PMIVELAEKA MKEYGEDLKI ETNKFAAICT HLEVCFMYSD    50
    FHFINERGES IIVESGDPNA LLKHRFEIIE GRDRTMAWTV VNSICNTTGA 100
    EKPKFLPDLY DYKENRFIEI GVTRREVHIY YLEKANKIKS EKTHIHIFSF 150
    TGEEMATKAD YTLDEESRAR IKTRLFTIRQ EMASRGLWDS FVSPREAKRQ 200
    LKKDLKSQEQ CAGLPTKVSH RTSPALKTLE PMWMDSNRTA TLRASFLKCP 250
    KK 252
    Length:252
    Mass (Da):29,378
    Last modified:October 3, 2012 - v1
    Checksum:i7D318D48B6267FDE
    GO
    Isoform PA (identifier: Q3HM39-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform can be found in the external entry Q3HM39.
    Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
    Length:716
    Mass (Da):82,599
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ208311 mRNA. No translation available.

    Keywords - Coding sequence diversityi

    Ribosomal frameshifting

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DQ208311 mRNA. No translation available.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Family and domain databases

    InterProi IPR001009. RNA-dir_pol_influenzavirus.
    [Graphical view ]
    Pfami PF00603. Flu_PA. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of the 1918 influenza virus polymerase genes."
      Taubenberger J.K., Reid A.H., Lourens R.M., Wang R., Jin G., Fanning T.G.
      Nature 437:889-893(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. Cited for: CHARACTERIZATION, FUNCTION.

    Entry informationi

    Entry nameiPAX_I18A0
    AccessioniPrimary (citable) accession number: P0CK68
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 3, 2012
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 7 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3