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Protein

Cytoplasmic envelopment protein 2

Gene

BGLF2

Organism
Epstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Plays a critical role in cytoplasmic virus egress. Participates in the final step of tegumentation and envelope acquisition within the host cytoplasm by directly interacting with the capsid. Upon virion binding to target cell, a signaling cascade is triggered to disrupt the interaction with the capsid, thereby preparing capsid uncoating.UniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytoplasmic envelopment protein 2UniRule annotation
Gene namesi
ORF Names:BGLF2
OrganismiEpstein-Barr virus (strain GD1) (HHV-4) (Human herpesvirus 4)
Taxonomic identifieri10376 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageHerpesviralesHerpesviridaeGammaherpesvirinaeLymphocryptovirus
Virus hostiHomo sapiens (Human) [TaxID: 9606]
Proteomesi
  • UP000007641 Componenti: Genome

Subcellular locationi

  • Virion tegument UniRule annotation
  • Host cytoplasm UniRule annotation
  • Host nucleus UniRule annotation

  • Note: Localizes in the host nucleus up to 18 hours postinfection, but at later times localizes to punctate, cytoplasmic structures.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host cytoplasm, Host nucleus, Virion, Virion tegument

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004159721 – 336Cytoplasmic envelopment protein 2Add BLAST336

Expressioni

Keywords - Developmental stagei

Late protein

Interactioni

Subunit structurei

Interacts with cytoplasmic envelopment protein 3 and with the capsid.UniRule annotation

Binary interactionsi

WithEntry#Exp.IntActNotes
BBLF1Q3KSR62EBI-9644810,EBI-9645091

Protein-protein interaction databases

BioGridi971810. 1 interactor.
IntActiP0CK55. 8 interactors.

Structurei

3D structure databases

ProteinModelPortaliP0CK55.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the herpesviridae cytoplasmic envelopment protein 2 family.UniRule annotation

Family and domain databases

HAMAPiMF_04039. HSV_CEP2. 1 hit.
InterProiIPR004286. Herpes_UL16/UL94.
[Graphical view]
PfamiPF03044. Herpes_UL16. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CK55-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASAANSSRE QLRKFLNKEC LWVLSDASTP QMKVYTATTA VSAVYVPQIA
60 70 80 90 100
GPPKTYMNVT LIVLKPKKKP TYVTVYINGT LATVARPEVL FTKAVQGPHS
110 120 130 140 150
LTLMYFGVFS DAVGEAVPVE IRGNPVVTCT DLTTAHVFTT STAVKTVEEL
160 170 180 190 200
QDITPSEIIP LGRGGAWYAE GALYMFFVNM DMLMCCPNMP TFPSLTHFIN
210 220 230 240 250
LLTRCDNGEC VTCYGAGAHV NILRGWTEDD SPGTSGTCPC LLPCTALNND
260 270 280 290 300
YVPITGHRAL LGLMFKPEDA PFVVGLRFNP PKMHPDMSRV LQGVLANGKE
310 320 330
VPCTAQPWTL LRFSDLYSRA MLYNCQVLKR QVLHSY
Length:336
Mass (Da):36,888
Last modified:March 21, 2012 - v1
Checksum:i840937A416D5584C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY961628 Genomic DNA. Translation: AAY41138.1.
RefSeqiYP_401691.1. NC_007605.1.

Genome annotation databases

GeneIDi3783768.
KEGGivg:3783768.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY961628 Genomic DNA. Translation: AAY41138.1.
RefSeqiYP_401691.1. NC_007605.1.

3D structure databases

ProteinModelPortaliP0CK55.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi971810. 1 interactor.
IntActiP0CK55. 8 interactors.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi3783768.
KEGGivg:3783768.

Family and domain databases

HAMAPiMF_04039. HSV_CEP2. 1 hit.
InterProiIPR004286. Herpes_UL16/UL94.
[Graphical view]
PfamiPF03044. Herpes_UL16. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEP2_EBVG
AccessioniPrimary (citable) accession number: P0CK55
Secondary accession number(s): P03221, Q777C8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: March 21, 2012
Last modified: November 2, 2016
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.