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P0CK32

- RDRP_REOVL

UniProt

P0CK32 - RDRP_REOVL

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Protein

RNA-directed RNA polymerase lambda-3

Gene
L1
Organism
Reovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

RNA-directed RNA polymerase that is involved in transcription and genome replication. Following infection, it catalyzes the synthesis of fully conservative plus strands. After core assembly, which consists in recruitment of one capped plus-strand for each genomic segments and polymerase complexes, the polymerase switches mode and catalyzes the synthesis of complementary minus-strands.

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

GO - Molecular functioni

  1. nucleotide binding Source: UniProtKB-KW
  2. RNA binding Source: InterPro
  3. RNA-directed RNA polymerase activity Source: UniProtKB-KW

GO - Biological processi

  1. viral genome replication Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase lambda-3 (EC:2.7.7.48)
Short name:
Lambda3
Alternative name(s):
Lambda3(Pol)
Gene namesi
Name:L1
OrganismiReovirus type 1 (strain Lang) (T1L) (Mammalian orthoreovirus 1)
Taxonomic identifieri10884 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesReoviridaeSpinareovirinaeOrthoreovirus
Virus hostiMammalia [TaxID: 40674]
ProteomesiUP000007253: Genome

Subcellular locationi

Virion Reviewed prediction
Note: Found in the inner capsid (12 copies).

GO - Cellular componenti

  1. viral nucleocapsid Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12671267RNA-directed RNA polymerase lambda-3PRO_0000222745Add
BLAST

Proteomic databases

PRIDEiP0CK32.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CSEelectron microscopy7.0011-1267[»]
ProteinModelPortaliP0CK32.

Miscellaneous databases

EvolutionaryTraceiP0CK32.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini555 – 792238RdRp catalyticAdd
BLAST

Sequence similaritiesi

Family and domain databases

InterProiIPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view]
PfamiPF07925. RdRP_5. 1 hit.
[Graphical view]
PROSITEiPS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CK32-1 [UniParc]FASTAAdd to Basket

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MSSMILTQFR PFIESISGIT DQSNDVFEDA AKAFSMFTRS DVYKALDEIP     50
FSDDAMLPIP PTIYTKPSHD SYYYIDALNR VRRKTYQGPD DVYVPNCSIV 100
ELLEPHETLT SYGRLSEAIE NRAKDGDSQA RIATTYGRIA ESQARQIKAP 150
LEKFVLALLV SEAGGSLYDP VLQKYDEIPD LSHNCPLWCF REICRHISGP 200
LPDRAPYLYL SAGVFWLMSP RMTSAIPPLL SDLVNLAILQ QTAGLDPSLV 250
KLGVQICLHA AASSSYAWFI LKTKSIFPQN TLHSMYESLE GGYCPNLEWL 300
EPRSDYKFMY MGVMPLSTKY ARSAPSNDKK ARELGEKYGL SSVVSELRKR 350
TKTYVKHDFA SVRYIRDAMA CTSGIFLVRT PTETVLQEYT QSPEIKVPIP 400
QKDWTGPVGE IRILKDTTSS IARYLYRTWY LAAARMAAQP RTWDPLFQAI 450
MRSQYVTARG GSGAALRESL YAINVSLPDF KGLPVKAATK IFQAAQLANL 500
PFSHTSVAIL ADTSMGLRNQ VQRRPRSIMP LNVPQQQVSA PHTLTADYIN 550
YHMNLSTTSG SAVIEKVIPL GVYASSPPNQ SINIDISACD ASITWDFFLS 600
VIMAAIHEGV ASGSIGKPFM GVPASIVNDE SVVGVRAARP ISGMQNMIQH 650
LSKLYKRGFS YRVNDSFSPG NDFTHMTTTF PSGSTATSTE HTANNSTMME 700
TFLTVWGPEH TDDPDVLRLM KSLTIQRNYV CQGDDGLMII DGNTAGKVNS 750
ETIQKMLELI SKYGEEFGWK YDIAYDGTAE YLKLYFIFGC RIPNLSRHPI 800
VGKERANSSA EEPWPAILDQ IMGIFFNGVH DGLQWQRWIR YSWALCCAFS 850
RQRTMIGESV GYLQYPMWSF VYWGLPLVKV FGSDPWIFSW YMPTGDLGMY 900
SWISLIRPLM TRWMVANGYA TDRCSPVFGN ADYRRCFNEI KLYQGYYMAQ 950
LPRNPTKSGR AAPREVREQF TQALSDYLMQ NPELKSRVLR GRSEWEKYGA 1000
GIIHNPPSLF DVPHKWYLGA QEAATATREE LAEMDETLMR ARRHSYSSFS 1050
KLLEAYLLVK WRMCEAREPS VDLRLPLCAG IDPLNSDPFL KMVSVGPMLQ 1100
STRKYFAQTL FMAKTVSGLD VNAIDSALLR LRTLGADKKA LTAQLLMVGL 1150
QESEADALAG KIMLQDVSTV QLARVVNLAV PDTWMSLDFD SMFKHHVKLL 1200
PKDGRHLNTD IPPRMGWLRA ILRFLGAGMV MTATGVAVDI YLEDIHGGGR 1250
ALGQRFMTWM RQEGRSA 1267
Length:1,267
Mass (Da):142,355
Last modified:December 14, 2011 - v1
Checksum:i157EBFD4D664FCDB
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24734 Genomic RNA. Translation: AAA47234.1.
PIRiA30121. MWXR31.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M24734 Genomic RNA. Translation: AAA47234.1 .
PIRi A30121. MWXR31.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2CSE electron microscopy 7.00 1 1-1267 [» ]
ProteinModelPortali P0CK32.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P0CK32.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P0CK32.

Family and domain databases

InterProi IPR012915. RdRP_5.
IPR007097. RNA-dir_pol_reovirus.
[Graphical view ]
Pfami PF07925. RdRP_5. 1 hit.
[Graphical view ]
PROSITEi PS50523. RDRP_DSRNA_REO. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The sequences of the reovirus serotype 1, 2, and 3 L1 genome segments and analysis of the mode of divergence of the reovirus serotypes."
    Wiener J.R., Joklik W.K.
    Virology 169:194-203(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
  2. "Features of reovirus outer capsid protein mu1 revealed by electron cryomicroscopy and image reconstruction of the virion at 7.0 Angstrom resolution."
    Zhang X., Ji Y., Zhang L., Harrison S.C., Marinescu D.C., Nibert M.L., Baker T.S.
    Structure 13:1545-1557(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY ELECTRON MICROSCOPY (7.0 ANGSTROMS).

Entry informationi

Entry nameiRDRP_REOVL
AccessioniPrimary (citable) accession number: P0CK32
Secondary accession number(s): A4ZY20
, P17376, P17378, Q85665
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 14, 2011
Last sequence update: December 14, 2011
Last modified: April 16, 2014
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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