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P0CJ90 (DU4L7_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 29. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Double homeobox protein 4-like protein 7
Gene names
Name:DUX4L7
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length424 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in transcriptional regulation By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 2 homeobox DNA-binding domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 424424Double homeobox protein 4-like protein 7
PRO_0000405255

Regions

DNA binding19 – 7860Homeobox 1
DNA binding94 – 15360Homeobox 2
Compositional bias156 – 24590Ala-rich
Compositional bias191 – 338148Pro-rich

Sequences

Sequence LengthMass (Da)Tools
P0CJ90 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: F26D864B7DFC4A11

FASTA42444,926
        10         20         30         40         50         60 
MALPTPSDST LPAEARGRGR RRRLVWTPSQ SEALRACFER NPYPGIATRE RLAQAIGIPE 

        70         80         90        100        110        120 
PRVQIWFQNE RSRQLRQHRR ESRPWPGRRG PPEGRRKRTA VTGSQTALLL RAFEKDRFPG 

       130        140        150        160        170        180 
IAAREELARE TGLPESRIQI WFQNRRARHP GQGGRAPAQA GGLCSAAPGG GHPAPSWVAF 

       190        200        210        220        230        240 
AHTGAWGTGL PAPHVPCAPG ALPQGAFVSQ AARAAPALQP SQAAPAEGVS QPAPARGDFA 

       250        260        270        280        290        300 
YAAPAPPDGA LSHPQAPRWP PHPGKSREDR DPQRDGLPGP CAVAQPGPAQ AGPQGQGVLA 

       310        320        330        340        350        360 
PPTSQGSPWW GWGRGPQVAG AAWEPQAGAA PPPQPAPPDA SASARQGQMQ GIPAPSQALQ 

       370        380        390        400        410        420 
EPAPWSALPC GLLLDELLAS PEFLQQAQPL LETEAPGELE ASEEAASLEA PLSEEEYRAL 


LEEL 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC126281 Genomic DNA. No translation available.
CCDSCCDS59483.2.
RefSeqNP_001120858.3. NM_001127386.2.
NP_001120859.3. NM_001127387.2.
NP_001120860.3. NM_001127388.2.
NP_001120861.3. NM_001127389.2.
NP_001157939.2. NM_001164467.2.
NP_149418.4. NM_033178.4.

3D structure databases

ProteinModelPortalP0CJ90.
SMRP0CJ90. Positions 20-77, 95-148.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP0CJ90.

Polymorphism databases

DMDM325530037.

Proteomic databases

PRIDEP0CJ90.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000553820; ENSP00000451411; ENSG00000258755.
ENST00000561772; ENSP00000455609; ENSG00000260155.
ENST00000566160; ENSP00000455807; ENSG00000260155.
GeneID22947.
653543.
653544.
653545.
653548.
728410.
KEGGhsa:22947.
hsa:653543.
hsa:653544.
hsa:653545.
hsa:653548.
hsa:728410.

Organism-specific databases

CTD22947.
653543.
653544.
653545.
653548.
728410.
GeneCardsGC04P190992.
HGNCHGNC:37266. DUX4L7.
neXtProtNX_P0CJ90.
GenAtlasSearch...

Phylogenomic databases

OrthoDBEOG7X9G7N.
PhylomeDBP0CJ90.

Gene expression databases

BgeeP0CJ90.

Family and domain databases

Gene3D1.10.10.60. 2 hits.
InterProIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 2 hits.
[Graphical view]
PRINTSPR00031. HTHREPRESSR.
SMARTSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS50071. HOMEOBOX_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

PROP0CJ90.

Entry information

Entry nameDU4L7_HUMAN
AccessionPrimary (citable) accession number: P0CJ90
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 9, 2014
This is version 29 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM