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P0CJ89

- DU4L6_HUMAN

UniProt

P0CJ89 - DU4L6_HUMAN

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Protein

Double homeobox protein 4-like protein 6

Gene
DUX4L6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi19 – 7860Homeobox 1Add
BLAST
DNA bindingi94 – 15360Homeobox 2Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding transcription factor activity Source: InterPro
  2. transcription regulatory region sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Double homeobox protein 4-like protein 6
Gene namesi
Name:DUX4L6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:37265. DUX4L6.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 424424Double homeobox protein 4-like protein 6PRO_0000405254Add
BLAST

Proteomic databases

PRIDEiP0CJ89.

PTM databases

PhosphoSiteiP0CJ89.

Structurei

3D structure databases

ProteinModelPortaliP0CJ89.
SMRiP0CJ89. Positions 20-77, 95-148.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 24590Ala-richAdd
BLAST
Compositional biasi191 – 338148Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

OrthoDBiEOG7X9G7N.
PhylomeDBiP0CJ89.

Family and domain databases

Gene3Di1.10.10.60. 2 hits.
InterProiIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamiPF00046. Homeobox. 2 hits.
[Graphical view]
PRINTSiPR00031. HTHREPRESSR.
SMARTiSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiPS50071. HOMEOBOX_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CJ89-1 [UniParc]FASTAAdd to Basket

« Hide

MALPTPSDST LPAEARGRGR RRRLVWTPSQ SEALRACFER NPYPGIATRE    50
RLAQAIGIPE PRVQIWFQNE RSRQLRQHRR ESRPWPGRRG PPEGRRKRTA 100
VTGSQTALLL RAFEKDRFPG IAAREELARE TGLPESRIQI WFQNRRARHP 150
GQGGRAPAQA GGLCSAAPGG GHPAPSWVAF AHTGAWGTGL PAPHVPCAPG 200
ALPQGAFVSQ AARAAPALQP SQAAPAEGVS QPAPARGDFA YAAPAPPDGA 250
LSHPQAPRWP PHPGKSREDR DPQRDGLPGP CAVAQPGPAQ AGPQGQGVLA 300
PPTSQGSPWW GWGRGPQVAG AAWEPQAGAA PPPQPAPPDA SASARQGQMQ 350
GIPAPSQALQ EPAPWSALPC GLLLDELLAS PEFLQQAQPL LETEAPGELE 400
ASEEAASLEA PLSEEEYRAL LEEL 424
Length:424
Mass (Da):44,926
Last modified:March 8, 2011 - v1
Checksum:iF26D864B7DFC4A11
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126281 Genomic DNA. No translation available.
RefSeqiNP_001120858.3. NM_001127386.2.
NP_001120859.3. NM_001127387.2.
NP_001120860.3. NM_001127388.2.
NP_001120861.3. NM_001127389.2.
NP_001157939.2. NM_001164467.2.
NP_149418.4. NM_033178.4.

Genome annotation databases

EnsembliENST00000553722; ENSP00000451087; ENSG00000258697.
ENST00000563106; ENSP00000455878; ENSG00000261755.
GeneIDi22947.
653543.
653544.
653545.
653548.
728410.
KEGGihsa:22947.
hsa:653543.
hsa:653544.
hsa:653545.
hsa:653548.
hsa:728410.

Polymorphism databases

DMDMi325530036.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC126281 Genomic DNA. No translation available.
RefSeqi NP_001120858.3. NM_001127386.2.
NP_001120859.3. NM_001127387.2.
NP_001120860.3. NM_001127388.2.
NP_001120861.3. NM_001127389.2.
NP_001157939.2. NM_001164467.2.
NP_149418.4. NM_033178.4.

3D structure databases

ProteinModelPortali P0CJ89.
SMRi P0CJ89. Positions 20-77, 95-148.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei P0CJ89.

Polymorphism databases

DMDMi 325530036.

Proteomic databases

PRIDEi P0CJ89.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000553722 ; ENSP00000451087 ; ENSG00000258697 .
ENST00000563106 ; ENSP00000455878 ; ENSG00000261755 .
GeneIDi 22947.
653543.
653544.
653545.
653548.
728410.
KEGGi hsa:22947.
hsa:653543.
hsa:653544.
hsa:653545.
hsa:653548.
hsa:728410.

Organism-specific databases

CTDi 22947.
653543.
653544.
653545.
653548.
728410.
GeneCardsi GC04P191016.
HGNCi HGNC:37265. DUX4L6.
neXtProti NX_P0CJ89.
GenAtlasi Search...

Phylogenomic databases

OrthoDBi EOG7X9G7N.
PhylomeDBi P0CJ89.

Miscellaneous databases

PROi P0CJ89.

Family and domain databases

Gene3Di 1.10.10.60. 2 hits.
InterProi IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view ]
Pfami PF00046. Homeobox. 2 hits.
[Graphical view ]
PRINTSi PR00031. HTHREPRESSR.
SMARTi SM00389. HOX. 2 hits.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 2 hits.
PROSITEi PS50071. HOMEOBOX_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDU4L6_HUMAN
AccessioniPrimary (citable) accession number: P0CJ89
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: April 16, 2014
This is version 28 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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