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Protein

Double homeobox protein 4-like protein 5

Gene

DUX4L5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi19 – 78Homeobox 1PROSITE-ProRule annotationAdd BLAST60
DNA bindingi94 – 153Homeobox 2PROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Double homeobox protein 4-like protein 5
Gene namesi
Name:DUX4L5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:38689. DUX4L5.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi653545.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004052531 – 424Double homeobox protein 4-like protein 5Add BLAST424

Proteomic databases

PaxDbiP0CJ88.
PRIDEiP0CJ88.

PTM databases

iPTMnetiP0CJ88.
PhosphoSitePlusiP0CJ88.

Expressioni

Organism-specific databases

HPAiHPA058451.

Structurei

3D structure databases

ProteinModelPortaliP0CJ88.
SMRiP0CJ88.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi156 – 245Ala-richAdd BLAST90
Compositional biasi191 – 338Pro-richAdd BLAST148

Keywords - Domaini

Homeobox, Repeat

Phylogenomic databases

eggNOGiKOG0849. Eukaryota.
ENOG410XS01. LUCA.
InParanoidiP0CJ88.
PhylomeDBiP0CJ88.

Family and domain databases

CDDicd00086. homeodomain. 2 hits.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR000047. HTH_motif.
PfamiView protein in Pfam
PF00046. Homeobox. 2 hits.
PRINTSiPR00031. HTHREPRESSR.
SMARTiView protein in SMART
SM00389. HOX. 2 hits.
SUPFAMiSSF46689. SSF46689. 2 hits.
PROSITEiView protein in PROSITE
PS50071. HOMEOBOX_2. 2 hits.

Sequencei

Sequence statusi: Complete.

P0CJ88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPTPSDST LPAEARGRGR RRRLVWTPSQ SEALRACFER NPYPGIATRE
60 70 80 90 100
RLAQAIGIPE PRVQIWFQNE RSRQLRQHRR ESRPWPGRRG PPEGRRKRTA
110 120 130 140 150
VTGSQTALLL RAFEKDRFPG IAAREELARE TGLPESRIQI WFQNRRARHP
160 170 180 190 200
GQGGRAPAQA GGLCSAAPGG GHPAPSWVAF AHTGAWGTGL PAPHVPCAPG
210 220 230 240 250
ALPQGAFVSQ AARAAPALQP SQAAPAEGVS QPAPARGDFA YAAPAPPDGA
260 270 280 290 300
LSHPQAPRWP PHPGKSREDR DPQRDGLPGP CAVAQPGPAQ AGPQGQGVLA
310 320 330 340 350
PPTSQGSPWW GWGRGPQVAG AAWEPQAGAA PPPQPAPPDA SASARQGQMQ
360 370 380 390 400
GIPAPSQALQ EPAPWSALPC GLLLDELLAS PEFLQQAQPL LETEAPGELE
410 420
ASEEAASLEA PLSEEEYRAL LEEL
Length:424
Mass (Da):44,926
Last modified:March 8, 2011 - v1
Checksum:iF26D864B7DFC4A11
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC126281 Genomic DNA. No translation available.

Similar proteinsi

Entry informationi

Entry nameiDU4L5_HUMAN
AccessioniPrimary (citable) accession number: P0CJ88
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: September 27, 2017
This is version 47 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM