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P0CJ88

- DU4L5_HUMAN

UniProt

P0CJ88 - DU4L5_HUMAN

Protein

Double homeobox protein 4-like protein 5

Gene

DUX4L5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 29 (01 Oct 2014)
      Sequence version 1 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    May be involved in transcriptional regulation.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi19 – 7860Homeobox 1PROSITE-ProRule annotationAdd
    BLAST
    DNA bindingi94 – 15360Homeobox 2PROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding transcription factor activity Source: InterPro
    2. transcription regulatory region sequence-specific DNA binding Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Double homeobox protein 4-like protein 5
    Gene namesi
    Name:DUX4L5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:38689. DUX4L5.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 424424Double homeobox protein 4-like protein 5PRO_0000405253Add
    BLAST

    Proteomic databases

    PRIDEiP0CJ88.

    PTM databases

    PhosphoSiteiP0CJ88.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CJ88.
    SMRiP0CJ88. Positions 20-77, 95-148.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi156 – 24590Ala-richAdd
    BLAST
    Compositional biasi191 – 338148Pro-richAdd
    BLAST

    Sequence similaritiesi

    Contains 2 homeobox DNA-binding domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox, Repeat

    Phylogenomic databases

    OrthoDBiEOG7X9G7N.
    PhylomeDBiP0CJ88.

    Family and domain databases

    Gene3Di1.10.10.60. 2 hits.
    InterProiIPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view]
    PfamiPF00046. Homeobox. 2 hits.
    [Graphical view]
    PRINTSiPR00031. HTHREPRESSR.
    SMARTiSM00389. HOX. 2 hits.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 2 hits.
    PROSITEiPS50071. HOMEOBOX_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CJ88-1 [UniParc]FASTAAdd to Basket

    « Hide

    MALPTPSDST LPAEARGRGR RRRLVWTPSQ SEALRACFER NPYPGIATRE    50
    RLAQAIGIPE PRVQIWFQNE RSRQLRQHRR ESRPWPGRRG PPEGRRKRTA 100
    VTGSQTALLL RAFEKDRFPG IAAREELARE TGLPESRIQI WFQNRRARHP 150
    GQGGRAPAQA GGLCSAAPGG GHPAPSWVAF AHTGAWGTGL PAPHVPCAPG 200
    ALPQGAFVSQ AARAAPALQP SQAAPAEGVS QPAPARGDFA YAAPAPPDGA 250
    LSHPQAPRWP PHPGKSREDR DPQRDGLPGP CAVAQPGPAQ AGPQGQGVLA 300
    PPTSQGSPWW GWGRGPQVAG AAWEPQAGAA PPPQPAPPDA SASARQGQMQ 350
    GIPAPSQALQ EPAPWSALPC GLLLDELLAS PEFLQQAQPL LETEAPGELE 400
    ASEEAASLEA PLSEEEYRAL LEEL 424
    Length:424
    Mass (Da):44,926
    Last modified:March 8, 2011 - v1
    Checksum:iF26D864B7DFC4A11
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126281 Genomic DNA. No translation available.
    RefSeqiNP_001120858.3. NM_001127386.2.
    NP_001120859.3. NM_001127387.2.
    NP_001120860.3. NM_001127388.2.
    NP_001120861.3. NM_001127389.2.
    NP_001157939.2. NM_001164467.2.
    NP_149418.4. NM_033178.4.

    Genome annotation databases

    EnsembliENST00000557283; ENSP00000451107; ENSG00000259063.
    ENST00000563535; ENSP00000457290; ENSG00000259063.
    GeneIDi22947.
    653543.
    653544.
    653545.
    653548.
    728410.
    KEGGihsa:22947.
    hsa:653543.
    hsa:653544.
    hsa:653545.
    hsa:653548.
    hsa:728410.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC126281 Genomic DNA. No translation available.
    RefSeqi NP_001120858.3. NM_001127386.2.
    NP_001120859.3. NM_001127387.2.
    NP_001120860.3. NM_001127388.2.
    NP_001120861.3. NM_001127389.2.
    NP_001157939.2. NM_001164467.2.
    NP_149418.4. NM_033178.4.

    3D structure databases

    ProteinModelPortali P0CJ88.
    SMRi P0CJ88. Positions 20-77, 95-148.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei P0CJ88.

    Proteomic databases

    PRIDEi P0CJ88.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000557283 ; ENSP00000451107 ; ENSG00000259063 .
    ENST00000563535 ; ENSP00000457290 ; ENSG00000259063 .
    GeneIDi 22947.
    653543.
    653544.
    653545.
    653548.
    728410.
    KEGGi hsa:22947.
    hsa:653543.
    hsa:653544.
    hsa:653545.
    hsa:653548.
    hsa:728410.

    Organism-specific databases

    CTDi 22947.
    653543.
    653544.
    653545.
    653548.
    728410.
    GeneCardsi GC04P191017.
    HGNCi HGNC:38689. DUX4L5.
    neXtProti NX_P0CJ88.
    GenAtlasi Search...

    Phylogenomic databases

    OrthoDBi EOG7X9G7N.
    PhylomeDBi P0CJ88.

    Miscellaneous databases

    PROi P0CJ88.

    Family and domain databases

    Gene3Di 1.10.10.60. 2 hits.
    InterProi IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR000047. HTH_motif.
    [Graphical view ]
    Pfami PF00046. Homeobox. 2 hits.
    [Graphical view ]
    PRINTSi PR00031. HTHREPRESSR.
    SMARTi SM00389. HOX. 2 hits.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 2 hits.
    PROSITEi PS50071. HOMEOBOX_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiDU4L5_HUMAN
    AccessioniPrimary (citable) accession number: P0CJ88
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 8, 2011
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 29 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3