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P0CJ87 (DU4L4_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 33. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Double homeobox protein 4-like protein 4
Gene names
Name:DUX4L4
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

May be involved in transcriptional regulation By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Contains 2 homeobox DNA-binding domains.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Double homeobox protein 4-like protein 4
PRO_0000405252

Regions

DNA binding19 – 7860Homeobox 1
DNA binding94 – 15360Homeobox 2
Compositional bias156 – 24590Ala-rich
Compositional bias191 – 367177Pro-rich

Sequences

Sequence LengthMass (Da)Tools
P0CJ87 [UniParc].

Last modified March 8, 2011. Version 1.
Checksum: 01E2DFA529FC6FB7

FASTA42244,826
        10         20         30         40         50         60 
MALPTPSDST LPAEARGRGR RRRLVWTPSQ SEALRACFER NPYPGIATRE RLAQAIGIPE 

        70         80         90        100        110        120 
PRVQIWFQNE RSRQLRQHRR ESRPWPGRRG PPEGRRKRTA VTGSQTALLL RAFEKDRFPG 

       130        140        150        160        170        180 
IAAREELARE TGLPESRIQI WFQNRRARHP GQGGRAPAQA GGLCSAAPGG GHPAPSWVAF 

       190        200        210        220        230        240 
AHTGAWGTGL PAPHVPCAPG ALPQGAFVSQ AARAAPALQP SQAAPAEGVS QPAPARGDFA 

       250        260        270        280        290        300 
YAAPAPPDGA LSHPQAPRWP PHPGKSREDR DPQRDGLPGP CAVAQPGPAQ AGPQGQGVLA 

       310        320        330        340        350        360 
PPTSQGSPWW GWGRGPQVAG AAWEPQAGEA PPPQPAPPDA SARQGQMQGI PAPSQALQEP 

       370        380        390        400        410        420 
APWSALPCGL LLDELLASPE FLQQAQPLLE TEAPGELEAS EEAASLEAPL SEEEYRALLE 


EL 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC126281 Genomic DNA. No translation available.
CCDSCCDS59484.2.
RefSeqNP_001170847.2. NM_001177376.2.

3D structure databases

ProteinModelPortalP0CJ87.
SMRP0CJ87. Positions 20-77, 95-148.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteP0CJ87.

Polymorphism databases

DMDM325530034.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000554637; ENSP00000451270; ENSG00000258834.
ENST00000566884; ENSP00000457577; ENSG00000260665.
GeneID441056.
KEGGhsa:441056.
UCSCuc021xvr.2. human.

Organism-specific databases

CTD441056.
GeneCardsGC04P191033.
HGNCHGNC:38686. DUX4L4.
neXtProtNX_P0CJ87.
GenAtlasSearch...

Phylogenomic databases

PhylomeDBP0CJ87.

Gene expression databases

BgeeP0CJ87.

Family and domain databases

Gene3D1.10.10.60. 2 hits.
InterProIPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR000047. HTH_motif.
[Graphical view]
PfamPF00046. Homeobox. 2 hits.
[Graphical view]
PRINTSPR00031. HTHREPRESSR.
SMARTSM00389. HOX. 2 hits.
[Graphical view]
SUPFAMSSF46689. SSF46689. 2 hits.
PROSITEPS50071. HOMEOBOX_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

PROP0CJ87.

Entry information

Entry nameDU4L4_HUMAN
AccessionPrimary (citable) accession number: P0CJ87
Entry history
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: March 8, 2011
Last modified: July 9, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM