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Protein

Humanin-like 7

Gene

MTRNR2L7

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Plays a role as a neuroprotective and antiapoptotic factor.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Humanin-like 7Curated
Short name:
HN71 Publication
Alternative name(s):
MT-RNR2-like protein 7Imported
Gene namesi
Name:MTRNR2L7Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:37164. MTRNR2L7.

Subcellular locationi

  • Secreted By similarity
  • Cytoplasm By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Secreted

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000256892.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004045561 – 24Humanin-like 7Add BLAST24

Proteomic databases

PaxDbiP0CJ74.
PRIDEiP0CJ74.

PTM databases

iPTMnetiP0CJ74.
PhosphoSitePlusiP0CJ74.

Expressioni

Tissue specificityi

Expressed in testis.1 Publication

Inductioni

Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.1 Publication

Gene expression databases

BgeeiENSG00000256892.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000439985.

Family & Domainsi

Sequence similaritiesi

Belongs to the humanin family.Curated

Phylogenomic databases

GeneTreeiENSGT00880000139036.
InParanoidiP0CJ74.

Family and domain databases

InterProiView protein in InterPro
IPR028139. Humanin.
PfamiView protein in Pfam
PF15040. Humanin. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CJ74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20 
MATGGFGCLL LLIREIDLSV KRQI
Length:24
Mass (Da):2,647
Last modified:February 8, 2011 - v1
Checksum:i0521ACE7DE17B4B1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121927 Genomic DNA. No translation available.
CCDSiCCDS53524.1.
RefSeqiNP_001177418.1. NM_001190489.1.
UniGeneiHs.727092.

Genome annotation databases

EnsembliENST00000544824; ENSP00000439985; ENSG00000256892.
GeneIDi100288485.
KEGGihsa:100288485.
UCSCiuc021ppd.2. human.

Similar proteinsi

Entry informationi

Entry nameiHMN7_HUMAN
AccessioniPrimary (citable) accession number: P0CJ74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: August 30, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

The humanin peptide has been shown to be biologically active but is the product of a mitochondrial gene, MT-RNR2. The mechanisms allowing the production and the secretion of humanin from the mitochondrial gene remaining unclear, the possibility exist that the physiologically active humanin peptide is encoded by one of the related genes present in the nuclear genome including the one described here (PubMed:19477263).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families