MTRNR2L6

Functionⁱ

Plays a role as a neuroprotective and antiapoptotic factor.By similarity

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Humanin-like 6Curated Short name: HN61 Publication Alternative name(s): MT-RNR2-like protein 6Imported
Gene namesⁱ	Name:MTRNR2L6Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000270672.1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:37163. MTRNR2L6.
neXtProtⁱ	NX_P0CJ73.

Keywords - Cellular componentⁱ

Cytoplasm, Secreted

Pathology & Biotechⁱ

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000270672.

OpenTargetsⁱ

ENSG00000270672.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000404555	1 – 24	Humanin-like 6Add BLAST		24

Proteomic databases

PRIDEⁱ	P0CJ73.

PRIDEⁱ

P0CJ73.

Expressionⁱ

Tissue specificityⁱ

Expressed in skeletal muscle and testis.1 Publication

Inductionⁱ

Down-regulated 6 hours following staurosporine (STS) treatment and up-regulated 24 hours following STS treatment. Down-regulated 6 hours following beta-carotene treatment, returning to its basal level 24 hours following beta-carotene treatment.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000270672.

Bgeeⁱ

ENSG00000270672.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the humanin family.Curated

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144562.
PhylomeDBⁱ	P0CJ73.

Family and domain databases

InterProⁱ	View protein in InterPro IPR028139. Humanin.
PANTHERⁱ	PTHR33895. PTHR33895. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15040. Humanin. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

P0CJ73-1 [UniParc]FASTA Add to basket

« Hide

        10         20 
MTPRGFSCLL LPTSETDLPV KRRT

Length:24

Mass (Da):2,719

Last modified:February 8, 2011 - v1

Checksum:ⁱFBE0A778F77FA270

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC231380 Genomic DNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS64784.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001177416.1. NM_001190487.2.

Genome annotation databases

Ensemblⁱ	ENST00000604952; ENSP00000473686; ENSG00000270672. ENST00000633925; ENSP00000488809; ENSG00000282017.
GeneIDⁱ	100463482.
KEGGⁱ	hsa:100463482.
UCSC genome browser More...UCSCⁱ	uc003vzz.3. human.

Similar proteinsⁱ

50% Identity

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
P0CJ73	Q8IVG9 P0DMP1 A0A2K6JQR7 A0A0D9SB39 P0CJ76 A0A0D9S9R7 P0CJ71 A0A2I2YAL5 H2RGI3 S4R3Y5 +15	Homo sapiens (Human) Rhinopithecus bieti (Black snub-nosed monkey) (Pygathrix bieti) Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus) Gorilla gorilla gorilla (Western lowland gorilla) Pan troglodytes (Chimpanzee) Callithrix jacchus (White-tufted-ear marmoset)	24	UniRef50_Q8IVG9	Cluster: Humanin	26

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC231380 Genomic DNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS64784.1.
NCBI Reference Sequences More...RefSeqⁱ	NP_001177416.1. NM_001190487.2.

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	P0CJ73.

PRIDEⁱ

P0CJ73.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000604952; ENSP00000473686; ENSG00000270672. ENST00000633925; ENSP00000488809; ENSG00000282017.
GeneIDⁱ	100463482.
KEGGⁱ	hsa:100463482.
UCSC genome browser More...UCSCⁱ	uc003vzz.3. human.

Organism-specific databases

CTDⁱ	100463482.
EuPathDBⁱ	HostDB:ENSG00000270672.1.
GeneCardsⁱ	MTRNR2L6.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:37163. MTRNR2L6.
neXtProtⁱ	NX_P0CJ73.
Open Targets More...OpenTargetsⁱ	ENSG00000270672.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144562.
PhylomeDBⁱ	P0CJ73.

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P0CJ73.

PROⁱ

PR:P0CJ73.

Gene expression databases

Bgeeⁱ	ENSG00000270672.

Bgeeⁱ

ENSG00000270672.

Family and domain databases

InterProⁱ	View protein in InterPro IPR028139. Humanin.
PANTHERⁱ	PTHR33895. PTHR33895. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF15040. Humanin. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	HMN6_HUMAN
Accessionⁱ	P0CJ73Primary (citable) accession number: P0CJ73
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 8, 2011
	Last sequence update:	February 8, 2011
	Last modified:	February 28, 2018
	This is version 39 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

The humanin peptide has been shown to be biologically active but is the product of a mitochondrial gene, MT-RNR2. The mechanisms allowing the production and the secretion of humanin from the mitochondrial gene remaining unclear, the possibility exist that the physiologically active humanin peptide is encoded by one of the related genes present in the nuclear genome including the one described here (PubMed:19477263).1 Publication

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P0CJ73 (HMN6_HUMAN)

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Humanin-like 6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Other locations

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

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Functionⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ