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Protein

RBPJ-interacting and tubulin-associated protein 1

Gene

rita1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Tubulin-binding protein that acts as a negative regulator of Notch signaling pathway. Shuttles between the cytoplasm and the nucleus and mediates the nuclear export of rbpj/rbpsuh, thereby preventing the interaction between rbpj/rbpsuh and NICD product of Notch proteins (Notch intracellular domain), leading to down-regulate Notch-mediated transcription. May play a role in neurogenesis.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of Notch signaling pathway Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • neurogenesis Source: UniProtKB
  • Notch signaling pathway Source: UniProtKB-KW
  • nuclear export Source: UniProtKB

Keywordsi

Biological processNeurogenesis, Notch signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
RBPJ-interacting and tubulin-associated protein 1
Alternative name(s):
RBPJ-interacting and tubulin-associated protein
Gene namesi
Name:rita1
Synonyms:rita
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleus Source: UniProtKB

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi12L → A: Results in nuclear accumulation; when associated with A-14 and A-16. 1 Publication1
Mutagenesisi14L → A: Results in nuclear accumulation; when associated with A-12 and A-16. 1 Publication1
Mutagenesisi16I → A: Results in nuclear accumulation; when associated with A-12 and A-14. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004045851 – 239RBPJ-interacting and tubulin-associated protein 1Add BLAST239

Interactioni

Subunit structurei

Interacts with rbpj/rbpsuh.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
RBPJQ063302EBI-8517225,EBI-632552From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

IntActiP0CJ62. 2 interactors.
MINTiMINT-8094751.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni129 – 158Interaction with RBPJ/RBPSUHBy similarityAdd BLAST30
Regioni158 – 239Interaction with tubulinBy similarityAdd BLAST82

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi12 – 24Nuclear export signalCuratedAdd BLAST13
Motifi93 – 109Nuclear localization signalBy similarityAdd BLAST17

Sequence similaritiesi

Belongs to the RITA family.Curated

Family and domain databases

InterProiView protein in InterPro
IPR031418. RITA1.
PfamiView protein in Pfam
PF17066. RITA. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CJ62-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPDNLYATNM SLDLSITGHS TALPQRKSRS TYRFKAANSY VDESLFGSSG
60 70 80 90 100
VRVDQTLQWN TAPPSQTPLL WSPGEIKENK KTSSCRPKST PAGTPRKKIQ
110 120 130 140 150
YRVKSRTPSY CDESLFGGKV EECTWDAPWV KKEDTVKIRP LLWSPSPRLV
160 170 180 190 200
QQSSMQNAKQ GPLRAVHPPE TSDSPLGTHK GLGAFWKPPE SDSDYSPSPF
210 220 230
SARQRQSTPG RETVRSASCS GRVTARRGSV KMQERPPWK
Length:239
Mass (Da):26,637
Last modified:February 8, 2011 - v1
Checksum:iD3EA216FC9371EF9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC070862 mRNA. No translation available.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiRITA1_XENLA
AccessioniPrimary (citable) accession number: P0CJ62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 8, 2011
Last sequence update: February 8, 2011
Last modified: November 11, 2015
This is version 12 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families