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P0CJ44

- ALF_COCIM

UniProt

P0CJ44 - ALF_COCIM

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Protein

Putative fructose-bisphosphate aldolase

Gene
CIMG_05755
Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis By similarity.

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Binds 2 zinc ions per subunit. One is catalytic and the other provides a structural contribution By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton donor By similarity
Metal bindingi87 – 871Zinc 1; catalytic By similarity
Metal bindingi116 – 1161Zinc 2 By similarity
Metal bindingi146 – 1461Zinc 2 By similarity
Metal bindingi192 – 1921Zinc 1; catalytic By similarity
Binding sitei193 – 1931Dihydroxyacetone phosphate; via amide nitrogen By similarity
Metal bindingi223 – 2231Zinc 1; catalytic By similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Putative fructose-1,6-bisphosphate aldolase
Gene namesi
ORF Names:CIMG_05755
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Putative fructose-bisphosphate aldolasePRO_0000403787Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Structurei

Secondary structure

1
302
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 209
Beta strandi25 – 295
Helixi33 – 4513
Beta strandi50 – 545
Helixi56 – 627
Helixi65 – 7612
Beta strandi81 – 888
Helixi91 – 999
Beta strandi111 – 1155
Helixi122 – 13716
Turni138 – 1403
Beta strandi142 – 1454
Beta strandi147 – 1493
Helixi170 – 1778
Turni178 – 1803
Beta strandi182 – 1843
Helixi204 – 21411
Turni215 – 2173
Beta strandi218 – 2225
Helixi230 – 2389
Beta strandi241 – 2477
Helixi248 – 26114
Turni262 – 2643
Helixi267 – 28822
Helixi294 – 2974

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PM6X-ray2.20A/B1-302[»]
ProteinModelPortaliP0CJ44.

Miscellaneous databases

EvolutionaryTraceiP0CJ44.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni224 – 2263Dihydroxyacetone phosphate binding By similarity
Regioni245 – 2484Dihydroxyacetone phosphate binding By similarity

Sequence similaritiesi

Phylogenomic databases

KOiK01624.
K13336.
OrthoDBiEOG79GTHR.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CJ44-1 [UniParc]FASTAAdd to Basket

« Hide

MPHPSLKSNR ALPLLTFART HSFAIPAICV YNLEGILAII RAAEHKRSPA    50
MILLFPWAIQ YADSLLVRTA ASACRAASVP ITLHLDHAQD PEIIKRAADL 100
SRSETHEPGF DSIMVDMSHF SKEENLRLTR ELVAYCNARG IATEAEPGRI 150
EGGEDGVQDT VDLEGVLTTP EESEEFVATG INWLAPAFGN VHGNYGPRGV 200
QLDYERLQRI NEAVGERVGL VLHGADPFTK EIFEKCIERG VAKVNVNRAV 250
NNEYVKVMRE KAGSLPITRL HEEVTNAMQA AVEKIMDMID STGKAEFMMD 300
EK 302
Length:302
Mass (Da):33,389
Last modified:January 11, 2011 - v1
Checksum:i3FBF318A0A3421C6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704912 Genomic DNA. Translation: EAS30503.2.
RefSeqiXP_001241859.1. XM_001241858.1.
XP_001242086.1. XM_001242085.1.

Genome annotation databases

GeneIDi4561635.
4561677.
KEGGicim:CIMG_05755.
cim:CIMG_05982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
GG704912 Genomic DNA. Translation: EAS30503.2 .
RefSeqi XP_001241859.1. XM_001241858.1.
XP_001242086.1. XM_001242085.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PM6 X-ray 2.20 A/B 1-302 [» ]
ProteinModelPortali P0CJ44.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4561635.
4561677.
KEGGi cim:CIMG_05755.
cim:CIMG_05982.

Phylogenomic databases

KOi K01624.
K13336.
OrthoDBi EOG79GTHR.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Miscellaneous databases

EvolutionaryTracei P0CJ44.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiALF_COCIM
AccessioniPrimary (citable) accession number: P0CJ44
Secondary accession number(s): J3K765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: June 11, 2014
This is version 22 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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