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P0CJ44

- ALF_COCIM

UniProt

P0CJ44 - ALF_COCIM

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Protein

Putative fructose-bisphosphate aldolase

Gene

CIMG_05755

Organism
Coccidioides immitis (strain RS) (Valley fever fungus)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis.By similarity

Catalytic activityi

D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei86 – 861Proton donorBy similarity
Metal bindingi87 – 871Zinc 1; catalyticBy similarity
Metal bindingi116 – 1161Zinc 2By similarity
Metal bindingi146 – 1461Zinc 2By similarity
Metal bindingi192 – 1921Zinc 1; catalyticBy similarity
Binding sitei193 – 1931Dihydroxyacetone phosphate; via amide nitrogenBy similarity
Metal bindingi223 – 2231Zinc 1; catalyticBy similarity

GO - Molecular functioni

  1. fructose-bisphosphate aldolase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00109; UER00183.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative fructose-bisphosphate aldolase (EC:4.1.2.13)
Short name:
FBP aldolase
Short name:
FBPA
Alternative name(s):
Putative fructose-1,6-bisphosphate aldolase
Gene namesi
ORF Names:CIMG_05755
OrganismiCoccidioides immitis (strain RS) (Valley fever fungus)
Taxonomic identifieri246410 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeOnygenalesmitosporic OnygenalesCoccidioides
ProteomesiUP000001261: Unassembled WGS sequence

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302Putative fructose-bisphosphate aldolasePRO_0000403787Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

Secondary structure

1
302
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi12 – 209Combined sources
Beta strandi25 – 295Combined sources
Helixi33 – 4513Combined sources
Beta strandi50 – 545Combined sources
Helixi56 – 627Combined sources
Helixi65 – 7612Combined sources
Beta strandi81 – 888Combined sources
Helixi91 – 999Combined sources
Beta strandi111 – 1155Combined sources
Helixi122 – 13716Combined sources
Turni138 – 1403Combined sources
Beta strandi142 – 1454Combined sources
Beta strandi147 – 1493Combined sources
Helixi170 – 1778Combined sources
Turni178 – 1803Combined sources
Beta strandi182 – 1843Combined sources
Helixi204 – 21411Combined sources
Turni215 – 2173Combined sources
Beta strandi218 – 2225Combined sources
Helixi230 – 2389Combined sources
Beta strandi241 – 2477Combined sources
Helixi248 – 26114Combined sources
Turni262 – 2643Combined sources
Helixi267 – 28822Combined sources
Helixi294 – 2974Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3PM6X-ray2.20A/B1-302[»]
ProteinModelPortaliP0CJ44.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CJ44.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni224 – 2263Dihydroxyacetone phosphate bindingBy similarity
Regioni245 – 2484Dihydroxyacetone phosphate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiP0CJ44.
KOiK01624.
K13336.
OrthoDBiEOG79GTHR.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view]
PfamiPF01116. F_bP_aldolase. 1 hit.
[Graphical view]
PIRSFiPIRSF001359. F_bP_aldolase_II. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CJ44-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPHPSLKSNR ALPLLTFART HSFAIPAICV YNLEGILAII RAAEHKRSPA
60 70 80 90 100
MILLFPWAIQ YADSLLVRTA ASACRAASVP ITLHLDHAQD PEIIKRAADL
110 120 130 140 150
SRSETHEPGF DSIMVDMSHF SKEENLRLTR ELVAYCNARG IATEAEPGRI
160 170 180 190 200
EGGEDGVQDT VDLEGVLTTP EESEEFVATG INWLAPAFGN VHGNYGPRGV
210 220 230 240 250
QLDYERLQRI NEAVGERVGL VLHGADPFTK EIFEKCIERG VAKVNVNRAV
260 270 280 290 300
NNEYVKVMRE KAGSLPITRL HEEVTNAMQA AVEKIMDMID STGKAEFMMD

EK
Length:302
Mass (Da):33,389
Last modified:January 11, 2011 - v1
Checksum:i3FBF318A0A3421C6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704912 Genomic DNA. Translation: EAS30503.2.
RefSeqiXP_001241859.1. XM_001241858.1.
XP_001242086.1. XM_001242085.1.

Genome annotation databases

GeneIDi4561635.
4561677.
KEGGicim:CIMG_05755.
cim:CIMG_05982.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
GG704912 Genomic DNA. Translation: EAS30503.2 .
RefSeqi XP_001241859.1. XM_001241858.1.
XP_001242086.1. XM_001242085.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3PM6 X-ray 2.20 A/B 1-302 [» ]
ProteinModelPortali P0CJ44.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 4561635.
4561677.
KEGGi cim:CIMG_05755.
cim:CIMG_05982.

Phylogenomic databases

InParanoidi P0CJ44.
KOi K01624.
K13336.
OrthoDBi EOG79GTHR.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00183 .

Miscellaneous databases

EvolutionaryTracei P0CJ44.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR000771. Ketose_bisP_aldolase_II.
[Graphical view ]
Pfami PF01116. F_bP_aldolase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001359. F_bP_aldolase_II. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: RS.
  2. Cited for: GENOME REANNOTATION.
    Strain: RS.

Entry informationi

Entry nameiALF_COCIM
AccessioniPrimary (citable) accession number: P0CJ44
Secondary accession number(s): J3K765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: November 26, 2014
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3