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Protein

Xylose isomerase

Gene

xylA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei107By similarity1
Active sitei110By similarity1
Metal bindingi238Magnesium 1By similarity1
Metal bindingi274Magnesium 1By similarity1
Metal bindingi274Magnesium 2By similarity1
Metal bindingi277Magnesium 2By similarity1
Metal bindingi302Magnesium 1By similarity1
Metal bindingi313Magnesium 2By similarity1
Metal bindingi315Magnesium 2By similarity1
Metal bindingi345Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism, Xylose metabolism
LigandMagnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:BSU17600
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001957671 – 445Xylose isomeraseAdd BLAST445

Proteomic databases

PaxDbiP0CI80
PRIDEiP0CI80

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009686

Structurei

3D structure databases

ProteinModelPortaliP0CI80
SMRiP0CI80
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105C93 Bacteria
COG2115 LUCA
HOGENOMiHOG000252293
InParanoidiP0CI80
KOiK01805
OMAiHTFQHEL
PhylomeDBiP0CI80

Family and domain databases

HAMAPiMF_00455 Xylose_isom_A, 1 hit
InterProiView protein in InterPro
IPR036237 Xyl_isomerase-like_sf
IPR013022 Xyl_isomerase-like_TIM-brl
IPR013452 Xylose_isom_bac
IPR001998 Xylose_isomerase
PANTHERiPTHR32176:SF0 PTHR32176:SF0, 1 hit
PfamiView protein in Pfam
PF01261 AP_endonuc_2, 1 hit
PRINTSiPR00688 XYLOSISMRASE
SUPFAMiSSF51658 SSF51658, 1 hit
TIGRFAMsiTIGR02630 xylose_isom_A, 1 hit
PROSITEiView protein in PROSITE
PS51415 XYLOSE_ISOMERASE, 1 hit

Sequencei

Sequence statusi: Complete.

P0CI80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSHSSSIN YFGSANKVVY EGKDSTNPLA FKYYNPQEVI GGKTLKEHLR
60 70 80 90 100
FSIAYWHTFT ADGTDVFGAA TMQRPWDHYK GMDLAKMRVE AAFEMFEKLD
110 120 130 140 150
APFFAFHDRD IAPEGSTLKE TNQNLDMIMG MIKDYMRNSG VKLLWNTANM
160 170 180 190 200
FTNPRFVHGA ATSCNADVFA YAAAQVKKGL ETAKELGAEN YVFWGGREGY
210 220 230 240 250
ETLLNTDLKF ELDNLARFMH MAVDYAKEIG YTGQFLIEPK PKEPTTHQYD
260 270 280 290 300
TDAATTIAFL KQYGLDNHFK LNLEANHATL AGHTFEHELR MARVHGLLGS
310 320 330 340 350
VDANQGHPLL GWDTDEFPTD LYSTTLAMYE ILQNGGLGSG GLNFDAKVRR
360 370 380 390 400
SSFEPDDLIY AHIAGMDAFA RGLKVAHKLI EDRVFEDVIQ HRYRSFTEGI
410 420 430 440
GLEIIEGRAN FHTLEQYALN HKSIKNESGR QEKLKAILNQ YILEV
Length:445
Mass (Da):50,282
Last modified:January 11, 2011 - v1
Checksum:i6A7E37F25E135AFD
GO

Sequence cautioni

The sequence CAA26562 differs from that shown. Reason: Frameshift at position 440.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9I → V in CAA26562 (Ref. 2) Curated1
Sequence conflicti15A → V in CAA26562 (Ref. 2) Curated1
Sequence conflicti20Y → F in CAA26562 (Ref. 2) Curated1
Sequence conflicti24D → A in CAA26562 (Ref. 2) Curated1
Sequence conflicti45L → M in CAA26562 (Ref. 2) Curated1
Sequence conflicti86 – 87KM → RA in CAA26562 (Ref. 2) Curated2
Sequence conflicti127 – 129MIM → IIV in CAA26562 (Ref. 2) Curated3
Sequence conflicti138 – 140NSG → DSN in CAA26562 (Ref. 2) Curated3
Sequence conflicti214N → D in AAB41093 (PubMed:2994009).Curated1
Sequence conflicti230G → E in CAA26562 (Ref. 2) Curated1
Sequence conflicti246T → A in AAB41093 (PubMed:2994009).Curated1
Sequence conflicti359I → V in CAA26562 (Ref. 2) Curated1
Sequence conflicti405I → T in CAA26562 (Ref. 2) Curated1
Sequence conflicti421 – 423HKS → NKT in CAA26562 (Ref. 2) Curated3
Sequence conflicti433K → R in CAA26562 (Ref. 2) Curated1
Sequence conflicti436A → P in CAA26562 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02795 Genomic DNA Translation: CAA26562.1 Frameshift.
U66480 Genomic DNA Translation: AAB41093.1
AL009126 Genomic DNA Translation: CAB13644.2
PIRiC69735 ISBSXS
RefSeqiNP_389642.2, NC_000964.3
WP_003245235.1, NZ_JNCM01000035.1

Genome annotation databases

EnsemblBacteriaiCAB13644; CAB13644; BSU17600
GeneIDi939558
KEGGibsu:BSU17600
PATRICifig|224308.179.peg.1910

Similar proteinsi

Entry informationi

Entry nameiXYLA_BACSU
AccessioniPrimary (citable) accession number: P0CI80
Secondary accession number(s): P04788, P94491
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: May 23, 2018
This is version 45 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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