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Protein

Xylose isomerase

Gene

xylA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

D-xylopyranose = D-xylulose.

Cofactori

Mg2+By similarityNote: Binds 2 magnesium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei107 – 1071By similarity
Active sitei110 – 1101By similarity
Metal bindingi238 – 2381Magnesium 1By similarity
Metal bindingi274 – 2741Magnesium 1By similarity
Metal bindingi274 – 2741Magnesium 2By similarity
Metal bindingi277 – 2771Magnesium 2By similarity
Metal bindingi302 – 3021Magnesium 1By similarity
Metal bindingi313 – 3131Magnesium 2By similarity
Metal bindingi315 – 3151Magnesium 2By similarity
Metal bindingi345 – 3451Magnesium 1By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism, Pentose shunt, Xylose metabolism

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Xylose isomerase (EC:5.3.1.5)
Gene namesi
Name:xylA
Ordered Locus Names:BSU17600
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Xylose isomerasePRO_0000195767Add
BLAST

Proteomic databases

PaxDbiP0CI80.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009686.

Structurei

3D structure databases

ProteinModelPortaliP0CI80.
SMRiP0CI80. Positions 11-445.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the xylose isomerase family.Curated

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
InParanoidiP0CI80.
KOiK01805.
OMAiHTFQHEL.
PhylomeDBiP0CI80.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CI80-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAQSHSSSIN YFGSANKVVY EGKDSTNPLA FKYYNPQEVI GGKTLKEHLR
60 70 80 90 100
FSIAYWHTFT ADGTDVFGAA TMQRPWDHYK GMDLAKMRVE AAFEMFEKLD
110 120 130 140 150
APFFAFHDRD IAPEGSTLKE TNQNLDMIMG MIKDYMRNSG VKLLWNTANM
160 170 180 190 200
FTNPRFVHGA ATSCNADVFA YAAAQVKKGL ETAKELGAEN YVFWGGREGY
210 220 230 240 250
ETLLNTDLKF ELDNLARFMH MAVDYAKEIG YTGQFLIEPK PKEPTTHQYD
260 270 280 290 300
TDAATTIAFL KQYGLDNHFK LNLEANHATL AGHTFEHELR MARVHGLLGS
310 320 330 340 350
VDANQGHPLL GWDTDEFPTD LYSTTLAMYE ILQNGGLGSG GLNFDAKVRR
360 370 380 390 400
SSFEPDDLIY AHIAGMDAFA RGLKVAHKLI EDRVFEDVIQ HRYRSFTEGI
410 420 430 440
GLEIIEGRAN FHTLEQYALN HKSIKNESGR QEKLKAILNQ YILEV
Length:445
Mass (Da):50,282
Last modified:January 11, 2011 - v1
Checksum:i6A7E37F25E135AFD
GO

Sequence cautioni

The sequence CAA26562 differs from that shown. Reason: Frameshift at position 440. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti9 – 91I → V in CAA26562 (Ref. 2) Curated
Sequence conflicti15 – 151A → V in CAA26562 (Ref. 2) Curated
Sequence conflicti20 – 201Y → F in CAA26562 (Ref. 2) Curated
Sequence conflicti24 – 241D → A in CAA26562 (Ref. 2) Curated
Sequence conflicti45 – 451L → M in CAA26562 (Ref. 2) Curated
Sequence conflicti86 – 872KM → RA in CAA26562 (Ref. 2) Curated
Sequence conflicti127 – 1293MIM → IIV in CAA26562 (Ref. 2) Curated
Sequence conflicti138 – 1403NSG → DSN in CAA26562 (Ref. 2) Curated
Sequence conflicti214 – 2141N → D in AAB41093 (PubMed:2994009).Curated
Sequence conflicti230 – 2301G → E in CAA26562 (Ref. 2) Curated
Sequence conflicti246 – 2461T → A in AAB41093 (PubMed:2994009).Curated
Sequence conflicti359 – 3591I → V in CAA26562 (Ref. 2) Curated
Sequence conflicti405 – 4051I → T in CAA26562 (Ref. 2) Curated
Sequence conflicti421 – 4233HKS → NKT in CAA26562 (Ref. 2) Curated
Sequence conflicti433 – 4331K → R in CAA26562 (Ref. 2) Curated
Sequence conflicti436 – 4361A → P in CAA26562 (Ref. 2) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02795 Genomic DNA. Translation: CAA26562.1. Frameshift.
U66480 Genomic DNA. Translation: AAB41093.1.
AL009126 Genomic DNA. Translation: CAB13644.2.
PIRiC69735. ISBSXS.
RefSeqiNP_389642.2. NC_000964.3.
WP_003245235.1. NZ_JNCM01000035.1.

Genome annotation databases

EnsemblBacteriaiCAB13644; CAB13644; BSU17600.
GeneIDi939558.
KEGGibsu:BSU17600.
PATRICi18975335. VBIBacSub10457_1859.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X02795 Genomic DNA. Translation: CAA26562.1. Frameshift.
U66480 Genomic DNA. Translation: AAB41093.1.
AL009126 Genomic DNA. Translation: CAB13644.2.
PIRiC69735. ISBSXS.
RefSeqiNP_389642.2. NC_000964.3.
WP_003245235.1. NZ_JNCM01000035.1.

3D structure databases

ProteinModelPortaliP0CI80.
SMRiP0CI80. Positions 11-445.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi224308.Bsubs1_010100009686.

Proteomic databases

PaxDbiP0CI80.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB13644; CAB13644; BSU17600.
GeneIDi939558.
KEGGibsu:BSU17600.
PATRICi18975335. VBIBacSub10457_1859.

Phylogenomic databases

eggNOGiENOG4105C93. Bacteria.
COG2115. LUCA.
HOGENOMiHOG000252293.
InParanoidiP0CI80.
KOiK01805.
OMAiHTFQHEL.
PhylomeDBiP0CI80.

Family and domain databases

Gene3Di3.20.20.150. 1 hit.
HAMAPiMF_00455. Xylose_isom_A. 1 hit.
InterProiIPR013022. Xyl_isomerase-like_TIM-brl.
IPR013452. Xylose_isom_bac.
IPR001998. Xylose_isomerase.
[Graphical view]
PfamiPF01261. AP_endonuc_2. 1 hit.
[Graphical view]
PRINTSiPR00688. XYLOSISMRASE.
SUPFAMiSSF51658. SSF51658. 1 hit.
TIGRFAMsiTIGR02630. xylose_isom_A. 1 hit.
PROSITEiPS51415. XYLOSE_ISOMERASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiXYLA_BACSU
AccessioniPrimary (citable) accession number: P0CI80
Secondary accession number(s): P04788, P94491
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: January 11, 2011
Last modified: September 7, 2016
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.