P0CI42 (KBX23_LYCMC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Neurotoxin beta-KTx 14.3
Organism	Lychas mucronatus (Chinese swimming scorpion)
Taxonomic identifier	172552 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Chelicerata › Arachnida › Scorpiones › Buthida › Buthoidea › Buthidae › Lychas

Protein attributes

Sequence length	85 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Isoform 1 has a very weak effect to block voltage-gated potassium channel Kv1.1/KCNA1. Ref.1 Isoform 2 has a very weak effect to block voltage-gated potassium channel Kv1.1/KCNA1. Ref.1
Subcellular location	Secreted By similarity.
Tissue specificity	Expressed by the venom gland.
Sequence similarities	Belongs to the long chain scorpion toxin family. Class 2 subfamily.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Alternative splicing
Domain	Signal
Molecular function	Ion channel impairing toxin Neurotoxin Potassium channel inhibitor Toxin
PTM	Disulfide bond
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	potassium channel inhibitor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P0CI42-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P0CI42-2)

The sequence of this isoform differs from the canonical sequence as follows:
     37-39: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 20	20	Potential
	Propeptide	21 – 37	17	Probable		PRO_0000403850
	Chain	38 – 85	48	Neurotoxin beta-KTx 14.3		PRO_0000403851
Amino acid modifications
	Disulfide bond	52 ↔ 72		By similarity
	Disulfide bond	59 ↔ 77		By similarity
	Disulfide bond	63 ↔ 79		By similarity
Natural variations
	Alternative sequence	37 – 39	3	Missing in isoform 2.		VSP_040456

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 11, 2011. Version 1. Checksum: 4647B291E448A789	FASTA	85	9,425
	10 20 30 40 50 60 MKQYIFFLAL IVLTATFAEA GKKTEILDKV KKVFSKGIAG VADLNNMSEL GCPFIEKWCE 70 80 DHCESKKQVG KCENFDCSCV KLGGK
	Isoform 2 [UniParc]. Checksum: 8FB616F47DFA419E	FASTA	82	9,184
	10 20 30 40 50 60 MKQYIFFLAL IVLTATFAEA GKKTEILDKV KKVFSKGVAD LNNMSELGCP FIEKWCEDHC 70 80 ESKKQVGKCE NFDCSCVKLG GK

References

[1]

"Comparative venom gland transcriptome analysis of the scorpion Lychas mucronatus reveals intraspecific toxic gene diversity and new venomous components." Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X. BMC Genomics 11:452-452(2010) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, ALTERNATIVE SPLICING. Strain: Yunnan. Tissue: Venom gland.

Cross-references

Sequence databases
EMBL GenBank DDBJ	GT028643 mRNA. No translation available. GT028645 mRNA. No translation available.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

KBX23_LYCMC

Accession

Primary (citable) accession number: P0CI42

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2011
Last sequence update:	January 11, 2011
Last modified:	March 6, 2013
This is version 5 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Animal Toxin Annotation Program