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Protein

Tripartite motif-containing protein 49

Gene

TRIM49

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 56RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri88 – 129B box-typePROSITE-ProRule annotationAdd BLAST42

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Tripartite motif-containing protein 49
Alternative name(s):
RING finger protein 18
Testis-specific RING-finger protein
Gene namesi
Name:TRIM49
Synonyms:RNF18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:13431. TRIM49.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000168930.

Polymorphism and mutation databases

BioMutaiTRIM49.
DMDMi310947307.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000562731 – 452Tripartite motif-containing protein 49Add BLAST452

Proteomic databases

EPDiP0CI25.
PaxDbiP0CI25.
PRIDEiP0CI25.

PTM databases

iPTMnetiP0CI25.
PhosphoSitePlusiP0CI25.

Expressioni

Tissue specificityi

Preferentially expressed in testis.

Gene expression databases

ExpressionAtlasiP0CI25. baseline and differential.
GenevisibleiP0CI25. HS.

Organism-specific databases

HPAiCAB009968.

Interactioni

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi121361. 6 interactors.
IntActiP0CI25. 4 interactors.
STRINGi9606.ENSP00000327604.

Structurei

3D structure databases

ProteinModelPortaliP0CI25.
SMRiP0CI25.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini269 – 452B30.2/SPRYPROSITE-ProRule annotationAdd BLAST184

Sequence similaritiesi

Belongs to the TRIM/RBCC family.Curated
Contains 1 B box-type zinc finger.PROSITE-ProRule annotation
Contains 1 B30.2/SPRY domain.PROSITE-ProRule annotation
Contains 1 RING-type zinc finger.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri15 – 56RING-typePROSITE-ProRule annotationAdd BLAST42
Zinc fingeri88 – 129B box-typePROSITE-ProRule annotationAdd BLAST42

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129725.
HOGENOMiHOG000234135.
InParanoidiP0CI25.
KOiK12019.
OMAiANNDIFL.
OrthoDBiEOG091G05RG.
PhylomeDBiP0CI25.
TreeFamiTF338674.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CI25-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSGILQVFQ GELICPLCMN YFIDPVTIDC GHSFCRPCFY LNWQDIPFLV
60 70 80 90 100
QCSECTKSTE QINLKTNIHL KKMASLARKV SLWLFLSSEE QMCGTHRETK
110 120 130 140 150
KIFCEVDRSL LCLLCSSSQE HRYHRHRPIE WAAEEHREKL LQKMQSLWEK
160 170 180 190 200
ACENHRNLNV ETTRTRCWKD YVNLRLEAIR AEYQKMPAFH HEEEKHNLEM
210 220 230 240 250
LKKKGKEIFH RLHLSKAKMA HRMEILRGMY EELNEMCHKP DVELLQAFGD
260 270 280 290 300
ILHRSESVLL HMPQPLNPEL SAGPITGLRD RLNQFRVHIT LHHEEANNDI
310 320 330 340 350
FLYEILRSMC IGCDHQDVPY FTATPRSFLA WGVQTFTSGK YYWEVHVGDS
360 370 380 390 400
WNWAFGVCNM YRKEKNQNEK IDGKAGLFLL GCVKNDIQCS LFTTSPLMLQ
410 420 430 440 450
YIPKPTSRVG LFLDCEAKTV SFVDVNQSSL IYTIPNCSFS PPLRPIFCCI

HF
Length:452
Mass (Da):52,888
Last modified:November 2, 2010 - v1
Checksum:i5FB6528E7B5BB4BB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti298N → S in AAH75019 (PubMed:15489334).Curated1
Sequence conflicti298N → S in AAH75020 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061824373G → R.Corresponds to variant rs12417980dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037682 mRNA. Translation: BAB03503.1.
AP004607 Genomic DNA. No translation available.
BC075019 mRNA. Translation: AAH75019.1.
BC075020 mRNA. Translation: AAH75020.1.
BC126472 mRNA. Translation: AAI26473.1.
CCDSiCCDS8287.1.
RefSeqiNP_065091.1. NM_020358.2.
UniGeneiHs.534218.

Genome annotation databases

EnsembliENST00000329758; ENSP00000327604; ENSG00000168930.
GeneIDi57093.
KEGGihsa:57093.
UCSCiuc001pdb.3. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB037682 mRNA. Translation: BAB03503.1.
AP004607 Genomic DNA. No translation available.
BC075019 mRNA. Translation: AAH75019.1.
BC075020 mRNA. Translation: AAH75020.1.
BC126472 mRNA. Translation: AAI26473.1.
CCDSiCCDS8287.1.
RefSeqiNP_065091.1. NM_020358.2.
UniGeneiHs.534218.

3D structure databases

ProteinModelPortaliP0CI25.
SMRiP0CI25.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi121361. 6 interactors.
IntActiP0CI25. 4 interactors.
STRINGi9606.ENSP00000327604.

PTM databases

iPTMnetiP0CI25.
PhosphoSitePlusiP0CI25.

Polymorphism and mutation databases

BioMutaiTRIM49.
DMDMi310947307.

Proteomic databases

EPDiP0CI25.
PaxDbiP0CI25.
PRIDEiP0CI25.

Protocols and materials databases

DNASUi57093.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000329758; ENSP00000327604; ENSG00000168930.
GeneIDi57093.
KEGGihsa:57093.
UCSCiuc001pdb.3. human.

Organism-specific databases

CTDi57093.
GeneCardsiTRIM49.
H-InvDBHIX0058982.
HGNCiHGNC:13431. TRIM49.
HPAiCAB009968.
MIMi606124. gene.
neXtProtiNX_P0CI25.
OpenTargetsiENSG00000168930.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2177. Eukaryota.
ENOG4111G04. LUCA.
GeneTreeiENSGT00840000129725.
HOGENOMiHOG000234135.
InParanoidiP0CI25.
KOiK12019.
OMAiANNDIFL.
OrthoDBiEOG091G05RG.
PhylomeDBiP0CI25.
TreeFamiTF338674.

Miscellaneous databases

GenomeRNAii57093.
PROiP0CI25.
SOURCEiSearch...

Gene expression databases

ExpressionAtlasiP0CI25. baseline and differential.
GenevisibleiP0CI25. HS.

Family and domain databases

Gene3Di3.30.40.10. 1 hit.
4.10.45.10. 1 hit.
InterProiIPR001870. B30.2/SPRY.
IPR003879. Butyrophylin.
IPR013320. ConA-like_dom.
IPR003877. SPRY_dom.
IPR000315. Znf_B-box.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00622. SPRY. 1 hit.
PF00643. zf-B_box. 1 hit.
[Graphical view]
PRINTSiPR01407. BUTYPHLNCDUF.
SMARTiSM00336. BBOX. 1 hit.
SM00184. RING. 1 hit.
SM00449. SPRY. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS50188. B302_SPRY. 1 hit.
PS50119. ZF_BBOX. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTRI49_HUMAN
AccessioniPrimary (citable) accession number: P0CI25
Secondary accession number(s): A0AVR7
, A0AVR9, Q6DJV1, Q9NS80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.