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Protein

Putative zinc finger protein 705B

Gene

ZNF705B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 705B
Gene namesi
Name:ZNF705B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:32284. ZNF705B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000215356.

Polymorphism and mutation databases

BioMutaiZNF705B.
DMDMi308191623.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003994661 – 300Putative zinc finger protein 705BAdd BLAST300

Proteomic databases

PaxDbiP0CI00.
PeptideAtlasiP0CI00.
PRIDEiP0CI00.

Expressioni

Gene expression databases

BgeeiENSG00000215356.

Interactioni

Protein-protein interaction databases

BioGridi573352. 1 interactor.
STRINGi9606.ENSP00000382987.

Structurei

3D structure databases

ProteinModelPortaliP0CI00.
SMRiP0CI00.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 78KRABPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri172 – 194C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri200 – 222C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri228 – 250C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri256 – 278C2H2-type 4; degeneratePROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128291.
InParanoidiP0CI00.
OMAiMLENIHH.
OrthoDBiEOG091G0C5V.
PhylomeDBiP0CI00.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CI00-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLEKVTFE DVAIDFTQEE WDMMDTSKRK LYRDVMLENI SHLVSLGYQI
60 70 80 90 100
SKSYIILQLE QGKELWWEGR VFLQDQNPDR ESALKKKHMI SMHPIIRKDT
110 120 130 140 150
STSMTMENSL ILEDPFEYND SGEDCTHSST ITQCLLTHSG KKPCVSKQCG
160 170 180 190 200
KSLRNLLSPK PRKQIHTKGK SYQCNLCEKA YTNCFYLRRH KMTHTGERPY
210 220 230 240 250
ACHLCGKAFT QCSHLRRHEK THTGERPYKC HQCGKAFIQS FNLRRHERTH
260 270 280 290 300
LGQKCYECDK SGKAFSQSSG FRGNKIIHIG EKPPACLLCG KAFSLSSDLR
Length:300
Mass (Da):34,732
Last modified:October 5, 2010 - v1
Checksum:i4A67650DFB3BC1F5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284P → H in BAF85275 (PubMed:14702039).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292586 mRNA. Translation: BAF85275.1.
AC130365 Genomic DNA. No translation available.
CCDSiCCDS55194.1.
RefSeqiNP_001180559.1. NM_001193630.1.
UniGeneiHs.546691.

Genome annotation databases

EnsembliENST00000400120; ENSP00000382987; ENSG00000215356.
GeneIDi100132396.
KEGGihsa:100132396.
UCSCiuc010lro.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292586 mRNA. Translation: BAF85275.1.
AC130365 Genomic DNA. No translation available.
CCDSiCCDS55194.1.
RefSeqiNP_001180559.1. NM_001193630.1.
UniGeneiHs.546691.

3D structure databases

ProteinModelPortaliP0CI00.
SMRiP0CI00.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi573352. 1 interactor.
STRINGi9606.ENSP00000382987.

Polymorphism and mutation databases

BioMutaiZNF705B.
DMDMi308191623.

Proteomic databases

PaxDbiP0CI00.
PeptideAtlasiP0CI00.
PRIDEiP0CI00.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400120; ENSP00000382987; ENSG00000215356.
GeneIDi100132396.
KEGGihsa:100132396.
UCSCiuc010lro.1. human.

Organism-specific databases

CTDi100132396.
GeneCardsiZNF705B.
HGNCiHGNC:32284. ZNF705B.
neXtProtiNX_P0CI00.
OpenTargetsiENSG00000215356.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128291.
InParanoidiP0CI00.
OMAiMLENIHH.
OrthoDBiEOG091G0C5V.
PhylomeDBiP0CI00.

Miscellaneous databases

GenomeRNAii100132396.

Gene expression databases

BgeeiENSG00000215356.

Family and domain databases

CDDicd07765. KRAB_A-box. 1 hit.
Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZ705B_HUMAN
AccessioniPrimary (citable) accession number: P0CI00
Secondary accession number(s): A8K971, A8MY01
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: November 30, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.