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Protein

Zinc finger protein 705D

Gene

ZNF705D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 705D
Gene namesi
Name:ZNF705D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

HGNCiHGNC:33202. ZNF705D.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiZNF705D.
DMDMi308191622.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 300300Zinc finger protein 705DPRO_0000332236Add
BLAST

Proteomic databases

EPDiP0CH99.
PaxDbiP0CH99.
PRIDEiP0CH99.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000382957.

Structurei

3D structure databases

ProteinModelPortaliP0CH99.
SMRiP0CH99. Positions 7-55, 113-300.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 7872KRABPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 4 C2H2-type zinc fingers.PROSITE-ProRule annotation
Contains 1 KRAB domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri172 – 19423C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri200 – 22223C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri228 – 25023C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri256 – 27823C2H2-type 4; degeneratePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128291.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP0CH99.
KOiK09228.
OMAiTHCSARR.
OrthoDBiEOG7QK0C6.
PhylomeDBiP0CH99.
TreeFamiTF338497.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CH99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLEKVTFE DVAIDFTQEE WDMMDTSKRK LYRDVMLENI SHLVSLGYQI
60 70 80 90 100
SKSYIILQLE QGKELWREGR VFLQDQNPDR ESALKKKHMI SMHPIIRKDA
110 120 130 140 150
STSMTMENSL ILEDPFEYND SGEDCTHSST ITQCLLTHSG KKPCVSKQCG
160 170 180 190 200
KSLRNLLSPK PRKQIHTKGK SYQCNLCEKA YTNCFYLRRH KMTHTGERPY
210 220 230 240 250
ACHLCGKAFT QCSHLRRHEK THTGERPYKC HQCGKAFIQS FNLRRHERTH
260 270 280 290 300
LGQKCYECDK SGKAFSQSSG FRGNKIIHIG EKPHACLLCG KAFSLSSDLR
Length:300
Mass (Da):34,712
Last modified:October 5, 2010 - v1
Checksum:i1E1C943AF352977B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti144 – 1441C → Y in AAI10824 (PubMed:15489334).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130366 Genomic DNA. No translation available.
BC110823 mRNA. Translation: AAI10824.1.
CCDSiCCDS43712.1.
RefSeqiNP_001034704.2. NM_001039615.3.
XP_011542134.1. XM_011543832.1.
XP_011542135.1. XM_011543833.1.
XP_011542136.1. XM_011543834.1.
UniGeneiHs.652228.

Genome annotation databases

EnsembliENST00000400078; ENSP00000445477; ENSG00000215343.
ENST00000400085; ENSP00000382957; ENSG00000215343.
GeneIDi728957.
KEGGihsa:728957.
UCSCiuc064kiq.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC130366 Genomic DNA. No translation available.
BC110823 mRNA. Translation: AAI10824.1.
CCDSiCCDS43712.1.
RefSeqiNP_001034704.2. NM_001039615.3.
XP_011542134.1. XM_011543832.1.
XP_011542135.1. XM_011543833.1.
XP_011542136.1. XM_011543834.1.
UniGeneiHs.652228.

3D structure databases

ProteinModelPortaliP0CH99.
SMRiP0CH99. Positions 7-55, 113-300.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000382957.

Polymorphism and mutation databases

BioMutaiZNF705D.
DMDMi308191622.

Proteomic databases

EPDiP0CH99.
PaxDbiP0CH99.
PRIDEiP0CH99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000400078; ENSP00000445477; ENSG00000215343.
ENST00000400085; ENSP00000382957; ENSG00000215343.
GeneIDi728957.
KEGGihsa:728957.
UCSCiuc064kiq.1. human.

Organism-specific databases

CTDi728957.
GeneCardsiZNF705D.
HGNCiHGNC:33202. ZNF705D.
neXtProtiNX_P0CH99.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00830000128291.
HOGENOMiHOG000234617.
HOVERGENiHBG018163.
InParanoidiP0CH99.
KOiK09228.
OMAiTHCSARR.
OrthoDBiEOG7QK0C6.
PhylomeDBiP0CH99.
TreeFamiTF338497.

Enzyme and pathway databases

ReactomeiR-HSA-212436. Generic Transcription Pathway.

Miscellaneous databases

GenomeRNAii728957.
NextBioi128840.
PROiP0CH99.

Family and domain databases

Gene3Di3.30.160.60. 5 hits.
InterProiIPR001909. KRAB.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF01352. KRAB. 1 hit.
PF00096. zf-C2H2. 1 hit.
[Graphical view]
SMARTiSM00349. KRAB. 1 hit.
SM00355. ZnF_C2H2. 3 hits.
[Graphical view]
SUPFAMiSSF109640. SSF109640. 1 hit.
PROSITEiPS50805. KRAB. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 3 hits.
PS50157. ZINC_FINGER_C2H2_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 8."
    Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
    , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
    Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Skin.

Entry informationi

Entry nameiZ705D_HUMAN
AccessioniPrimary (citable) accession number: P0CH99
Secondary accession number(s): A8K971, A8MY01, Q2TAN0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 5, 2010
Last sequence update: October 5, 2010
Last modified: March 16, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.