ID   HUGA_VESMC              Reviewed;          31 AA.
AC   P0CH89;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 1.
DT   25-MAY-2022, entry version 23.
DE   RecName: Full=Hyaluronidase;
DE            Short=Hya;
DE            EC=3.2.1.35;
DE   AltName: Full=Hyaluronoglucosaminidase;
DE   AltName: Allergen=Ves m 2;
DE   Flags: Fragment;
OS   Vespula maculifrons (Eastern yellow jacket) (Wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespula.
OX   NCBI_TaxID=7453;
RN   [1]
RP   PROTEIN SEQUENCE.
RA   Jacobson R.S., Hoffman D.R., Kemeny D.M.;
RT   "The cross-reactivity between bee and vespid hyaluronidases has a
RT   structural basis.";
RL   J. Allergy Clin. Immunol. 89:292-292(1992).
CC   -!- FUNCTION: Hydrolyzes high molecular weight hyaluronic acid to produce
CC       small oligosaccharides. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-
CC         glucosamine and D-glucuronate residues in hyaluronate.; EC=3.2.1.35;
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- PTM: Contains 2 disulfide bonds. {ECO:0000250}.
CC   -!- PTM: N-glycosylated on at least two Asn residues by identical
CC       heptasaccharide units composed of Man, GlcNAc, and Fuc residues in the
CC       molar ration of 3:2:2. {ECO:0000250}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 56 family. {ECO:0000305}.
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DR   AlphaFoldDB; P0CH89; -.
DR   Allergome; 3515; Ves m 2.0101.
DR   Allergome; 662; Ves m 2.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004415; F:hyalurononglucosaminidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0008152; P:metabolic process; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Glycoprotein;
KW   Glycosidase; Hydrolase; Secreted.
FT   CHAIN           1..>31
FT                   /note="Hyaluronidase"
FT                   /id="PRO_0000401923"
FT   NON_TER         31
SQ   SEQUENCE   31 AA;  3848 MW;  FFF02ACAEF547B89 CRC64;
     DRCIWPKEGF SIYWNIPTHF CHNFGVYFKE L
//