P0CH89 (HUGA_VESMC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Hyaluronidase Short name=Hya EC=3.2.1.35 Alternative name(s): Hyaluronoglucosaminidase Allergen=Ves m 2
Organism	Vespula maculifrons (Eastern yellow jacket) (Wasp)
Taxonomic identifier	7453 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Vespoidea › Vespidae › Vespinae › Vespula

Protein attributes

Sequence length	31 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Hydrolyzes high molecular weight hyaluronic acid to produce small oligosaccharides By similarity.
Catalytic activity	Random hydrolysis of (1->4)-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate.
Subcellular location	Secreted.
Tissue specificity	Expressed by the venom gland.
Post-translational modification	Contains 2 disulfide bonds By similarity. N-glycosylated on at least two Asn residues by identical heptasaccharide units composed of Man, GlcNAc, and Fuc residues in the molar ration of 3:2:2 By similarity.
Allergenic properties	Causes an allergic reaction in human.
Sequence similarities	Belongs to the glycosyl hydrolase 56 family.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Molecular function	Glycosidase Hydrolase
PTM	Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	hyalurononglucosaminidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›31	›31	Hyaluronidase		PRO_0000401923
Experimental info
	Non-terminal residue	31	1

Sequences

	Sequence		Length	Mass (Da)
	P0CH89 [UniParc]. Last modified November 30, 2010. Version 1. Checksum: FFF02ACAEF547B89	FASTA	31	3,848
	10 20 30 DRCIWPKEGF SIYWNIPTHF CHNFGVYFKE L

References

[1]	"The cross-reactivity between bee and vespid hyaluronidases has a structural basis." Jacobson R.S., Hoffman D.R., Kemeny D.M. J. Allergy Clin. Immunol. 89:292-292(1992) Cited for: PROTEIN SEQUENCE.

Cross-references

3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	3515. Ves m 2.0101. 662. Ves m 2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

HUGA_VESMC

Accession

Primary (citable) accession number: P0CH89

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 30, 2010
Last sequence update:	November 30, 2010
Last modified:	March 6, 2013
This is version 9 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)