P0CH88 (SP4_BOMTE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Venom protease EC=3.4.21.- Alternative name(s): Allergen=Bom t 4
Organism	Bombus terrestris (Buff-tailed bumblebee) (Apis terrestris)
Taxonomic identifier	30195 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Ecdysozoa › Panarthropoda › Arthropoda › Mandibulata › Pancrustacea › Hexapoda › Insecta › Dicondylia › Pterygota › Neoptera › Endopterygota › Hymenoptera › Apocrita › Aculeata › Apoidea › Apidae › Bombinae › Bombini › Bombus › Bombus

Protein attributes

Sequence length	20 AA.
Sequence status	Fragment.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Ref.1.
Tissue specificity	Expressed by the venom duct. Ref.1
Post-translational modification	Contains 3 disulfide bonds By similarity. N-glycosylated By similarity.
Allergenic properties	Causes an allergic reaction in human. Ref.1
Sequence similarities	Belongs to the peptidase S1 family. Contains 1 peptidase S1 domain.

Ontologies

Keywords
Cellular component	Secreted
Disease	Allergen
Molecular function	Hydrolase Protease Serine protease
PTM	Disulfide bond Glycoprotein
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	serine-type peptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – ›20	›20	Venom protease		PRO_0000401925
Experimental info
	Non-terminal residue	20	1

Sequences

	Sequence		Length	Mass (Da)
	P0CH88 [UniParc]. Last modified November 30, 2010. Version 1. Checksum: B3ECC6677611C32F	FASTA	20	2,085
	10 20 VVGGKPAKLG AWPWMVALGF

References

[1]	"Occupational allergy to bumblebees: allergens of Bombus terrestris." Hoffman D.R., El-Choufani S.E., Smith M.M., de Groot H. J. Allergy Clin. Immunol. 108:855-860(2001) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALLERGEN. Tissue: Venom.

Cross-references

3D structure databases
ModBase	Search...
Protein family/group databases
Allergome	156. Bom t 4. 3160. Bom t 4.0101.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

SP4_BOMTE

Accession

Primary (citable) accession number: P0CH88

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 30, 2010
Last sequence update:	November 30, 2010
Last modified:	October 3, 2012
This is version 6 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)