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Protein

Venom protease

Gene
N/A
Organism
Bombus terrestris (Buff-tailed bumblebee) (Apis terrestris)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. serine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Names & Taxonomyi

Protein namesi
Recommended name:
Venom protease (EC:3.4.21.-)
Alternative name(s):
Allergen: Bom t 4
OrganismiBombus terrestris (Buff-tailed bumblebee) (Apis terrestris)
Taxonomic identifieri30195 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaHymenopteraApocritaAculeataApoideaApidaeBombusBombus

Subcellular locationi

  1. Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human.1 Publication

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei156. Bom t 4.
3160. Bom t 4.0101.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – ›20›20Venom proteasePRO_0000401925Add
BLAST

Post-translational modificationi

Contains 3 disulfide bonds.By similarity
N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Expressioni

Tissue specificityi

Expressed by the venom duct.1 Publication

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase S1 family.Curated
Contains 1 peptidase S1 domain.Curated

Family and domain databases

InterProiIPR009003. Trypsin-like_Pept_dom.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.

Sequencei

Sequence statusi: Fragment.

P0CH88-1 [UniParc]FASTAAdd to basket

« Hide

        10         20
VVGGKPAKLG AWPWMVALGF
Length:20
Mass (Da):2,085
Last modified:November 30, 2010 - v1
Checksum:iB3ECC6677611C32F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei20 – 201

Cross-referencesi

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei156. Bom t 4.
3160. Bom t 4.0101.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR009003. Trypsin-like_Pept_dom.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Occupational allergy to bumblebees: allergens of Bombus terrestris."
    Hoffman D.R., El-Choufani S.E., Smith M.M., de Groot H.
    J. Allergy Clin. Immunol. 108:855-860(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, ALLERGEN.
    Tissue: Venom.

Entry informationi

Entry nameiSP4_BOMTE
AccessioniPrimary (citable) accession number: P0CH88
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 30, 2010
Last sequence update: November 30, 2010
Last modified: January 7, 2015
This is version 11 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.