P0CH63 (DDI2_YEAST) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA damage-inducible protein 2

Gene names

Name:	DDI2
Ordered Locus Names:	YFL061W

Organism

Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]

Taxonomic identifier

559292 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Fungi › Dikarya › Ascomycota › saccharomyceta › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › Saccharomyces cerevisiae

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Induction

By DNA damage. Ref.4

Ontologies

Keywords
Molecular function	Lyase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cyanamide metabolic process Inferred from sequence or structural similarity. Source: UniProtKB response to DNA damage stimulus Inferred from expression pattern PubMed 9990050. Source: UniProtKB
Molecular_function	cyanamide hydratase activity Inferred from sequence or structural similarity. Source: UniProtKB phosphoric diester hydrolase activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 225	225	DNA damage-inducible protein 2		PRO_0000202670

Sequences

	Sequence		Length	Mass (Da)
	P0CH63 [UniParc]. Last modified October 5, 2010. Version 1. Checksum: F4890BF675E652B2	FASTA	225	25,152
	10 20 30 40 50 60 MSQYGFVRVP REVEKAIPVV NAPRPRAVVP PPNSETARLV REYAAKELTA PVLNHSLRVF 70 80 90 100 110 120 QYSVAIIRDQ FPAWDLDQEV LYVTCLLHDI ATTDKNMRAT KMSFEYYGGI LSRELVFNAT 130 140 150 160 170 180 GGNQDYADAV TEAIIRHQDL TGTGYITTLG LILQIATTLD NVGSNTDLIH IDTVSAINEQ 190 200 210 220 FPRLHWLSCF ATVVDTENSR KPWGHTSSLG DDFSKKVICN TFGYN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the nucleotide sequence of chromosome VI from Saccharomyces cerevisiae." Murakami Y., Naitou M., Hagiwara H., Shibata T., Ozawa M., Sasanuma S., Sasanuma M., Tsuchiya Y., Soeda E., Yokoyama K., Yamazaki M., Tashiro H., Eki T. Nat. Genet. 10:261-268(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 204511 / S288c / AB972.
[2]	Saccharomyces Genome Database Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: ATCC 204508 / S288c.
[3]	"Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae." Hu Y., Rolfs A., Bhullar B., Murthy T.V.S., Zhu C., Berger M.F., Camargo A.A., Kelley F., McCarron S., Jepson D., Richardson A., Raphael J., Moreira D., Taycher E., Zuo D., Mohr S., Kane M.F., Williamson J. , Simpson A.J.G., Bulyk M.L., Harlow E., Marsischky G., Kolodner R.D., LaBaer J. Genome Res. 17:536-543(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: ATCC 204508 / S288c.
[4]	"Rad6-Rad18 mediates a eukaryotic SOS response by ubiquitinating the 9-1-1 checkpoint clamp." Fu Y., Zhu Y., Zhang K., Yeung M., Durocher D., Xiao W. Cell 133:601-611(2008) [PubMed] [Europe PMC] [Abstract] Cited for: INDUCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D50617 Genomic DNA. Translation: BAA09180.1. AY692638 Genomic DNA. Translation: AAT92657.1. BK006940 Genomic DNA. Translation: DAA12379.1.
PIR	S56194.
RefSeq	NP_014064.1. NM_001183173.1. NP_116594.1. NM_001179906.1.
3D structure databases
ProteinModelPortal	P0CH63.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblFungi	YFL061W; YFL061W; YFL061W. YNL335W; YNL335W; YNL335W.
GeneID	850483. 855381.
KEGG	sce:YFL061W. sce:YNL335W.
Organism-specific databases
SGD	S000001833. DDI2.
Enzyme and pathway databases
BioCyc	YEAST:G3O-30406-MONOMER.
Gene expression databases
ArrayExpress	P0CH63.
GermOnline	YFL061W. Saccharomyces cerevisiae.
Family and domain databases
Gene3D	1.10.3210.10. 1 hit.
InterPro	IPR017771. Cyanamide_hydratase_HD. IPR003607. HD/PDEase_dom. IPR006674. HD_domain. [Graphical view]
Pfam	PF01966. HD. 1 hit. [Graphical view]
SMART	SM00471. HDc. 1 hit. [Graphical view]
TIGRFAMs	TIGR03401. cyanamide_fam. 1 hit.
ProtoNet	Search...
Other
NextBio	966143.

Entry information

Entry name

DDI2_YEAST

Accession

Primary (citable) accession number: P0CH63
Secondary accession number(s): D6VTG9, P43543

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 5, 2010
Last sequence update:	October 5, 2010
Last modified:	May 29, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Fungal Protein Annotation Program