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Protein

Conantokin-Br

Gene
N/A
Organism
Conus sulcatus (Sulcate cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Conantokins inhibit N-methyl-D-aspartate (NMDA) receptors. This toxin inhibits NR2 subunits N-methyl-D-aspartate (NMDA) receptor-mediated calcium influx in central nervous system neurons in the following order of preference: NR2B/GRIN2B (IC50=0.14 µM), NR2D/GRIN2D (IC50=0.31 µM), NR2A/GRIN2A (IC50=0.68 µM) and NR2C/GRIN2A (IC50=4.9 µM), when tested on rat receptors.1 Publication

Miscellaneous

The mature peptide does not contain cysteine residue.
Stabilized by divalent cations. Calcium, magnesium or zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei84Significant for the subtype selectivity between NR2B/GRIN2B and NR2D/GRIN2D (similar potency for both of them)1

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Ionotropic glutamate receptor inhibitor, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Conantokin-Br1 Publication
Short name:
Con-Br1 Publication
Alternative name(s):
Conantoxin-S11 Publication
Short name:
Con-S11 Publication
OrganismiConus sulcatus (Sulcate cone)
Taxonomic identifieri101760 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Organism-specific databases

ConoServeri4202. Conantokin-Br precursor.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi84 – 85YS → VA: 37-fold decrease in potency for NR2B/GRIN2B with a relative increase in selectivity for this subunit; complete decrease in potency for NR2D/GRIN2D. 1 Publication2
Mutagenesisi84Y → V: 23-fold decrease in potency for NR2B/GRIN2B with a relative increase in selectivity for this subunit; complete decrease in potency for NR2D/GRIN2D. 1 Publication1
Mutagenesisi87 – 88FI → MAA: Important decrease in potency for NR2B/GRIN2B; complete decrease in potency for NR2D/GRIN2D. 1 Publication2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000039561422 – 79By similarityAdd BLAST58
PeptideiPRO_000039561580 – 103Conantokin-BrAdd BLAST24

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei824-carboxyglutamateBy similarity1
Modified residuei834-carboxyglutamateBy similarity1
Modified residuei894-carboxyglutamateBy similarity1
Modified residuei934-carboxyglutamateBy similarity1

Keywords - PTMi

Gamma-carboxyglutamic acid

Expressioni

Tissue specificityi

Expressed by the venom duct.Curated

Structurei

3D structure databases

SMRiP0CG46.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the conotoxin B superfamily.Curated

Keywords - Domaini

Signal

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CG46-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLYTYLYLL VPLVTFHLIL GTGTLDHGGA LTERRSTDAT ALKPEPVLQK
60 70 80 90 100
SAARSTDDNG KDRLTQMKRI LKKRGKNARG DEEYSKFIER EREAGRLDLS

KFP
Length:103
Mass (Da):11,708
Last modified:July 13, 2010 - v1
Checksum:i76FF2E398C94C894
GO

Similar proteinsi

Entry informationi

Entry nameiCKBR_CONSL
AccessioniPrimary (citable) accession number: P0CG46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 22, 2017
This is version 20 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families