ID   CTGE8_HUMAN             Reviewed;         777 AA.
AC   P0CG41;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   24-JAN-2024, entry version 74.
DE   RecName: Full=cTAGE family member 8;
DE            Short=Protein cTAGE-8;
GN   Name=CTAGE8;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12853948; DOI=10.1038/nature01782;
RA   Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA   Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA   Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA   Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA   Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA   Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA   Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA   Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA   Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA   Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA   Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA   Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA   Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA   Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA   Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA   Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA   Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA   McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA   Wilson R.K.;
RT   "The DNA sequence of human chromosome 7.";
RL   Nature 424:157-164(2003).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the cTAGE family. {ECO:0000305}.
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DR   EMBL; AC004889; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS64791.1; -.
DR   RefSeq; NP_001265436.1; NM_001278507.1.
DR   AlphaFoldDB; P0CG41; -.
DR   SMR; P0CG41; -.
DR   BioGRID; 936688; 1.
DR   IntAct; P0CG41; 1.
DR   STRING; 9606.ENSP00000417289; -.
DR   iPTMnet; P0CG41; -.
DR   PhosphoSitePlus; P0CG41; -.
DR   BioMuta; CTAGE8; -.
DR   DMDM; 300680906; -.
DR   jPOST; P0CG41; -.
DR   MassIVE; P0CG41; -.
DR   MaxQB; P0CG41; -.
DR   PaxDb; 9606-ENSP00000417289; -.
DR   PeptideAtlas; P0CG41; -.
DR   Antibodypedia; 32719; 2 antibodies from 2 providers.
DR   DNASU; 100142659; -.
DR   Ensembl; ENST00000487179.2; ENSP00000417289.1; ENSG00000289604.1.
DR   Ensembl; ENST00000672571.1; ENSP00000500005.1; ENSG00000288181.1.
DR   Ensembl; ENST00000672823.1; ENSP00000500425.1; ENSG00000288181.1.
DR   GeneID; 100142659; -.
DR   KEGG; hsa:100142659; -.
DR   MANE-Select; ENST00000487179.2; ENSP00000417289.1; NM_001278507.2; NP_001265436.1.
DR   UCSC; uc010lpe.5; human.
DR   AGR; HGNC:37294; -.
DR   CTD; 100142659; -.
DR   GeneCards; CTAGE8; -.
DR   HGNC; HGNC:37294; CTAGE8.
DR   HPA; ENSG00000289604; Tissue enhanced (skin, thyroid gland).
DR   neXtProt; NX_P0CG41; -.
DR   VEuPathDB; HostDB:ENSG00000244693; -.
DR   eggNOG; ENOG502QUND; Eukaryota.
DR   GeneTree; ENSGT00950000182767; -.
DR   HOGENOM; CLU_002106_2_0_1; -.
DR   InParanoid; P0CG41; -.
DR   OMA; PYGFPWD; -.
DR   PhylomeDB; P0CG41; -.
DR   TreeFam; TF333137; -.
DR   PathwayCommons; P0CG41; -.
DR   BioGRID-ORCS; 100142659; 53 hits in 211 CRISPR screens.
DR   GenomeRNAi; 100142659; -.
DR   Pharos; P0CG41; Tdark.
DR   PRO; PR:P0CG41; -.
DR   Proteomes; UP000005640; Chromosome 7.
DR   RNAct; P0CG41; Protein.
DR   Bgee; ENSG00000244693; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 84 other cell types or tissues.
DR   GO; GO:0070971; C:endoplasmic reticulum exit site; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IBA:GO_Central.
DR   GO; GO:0006888; P:endoplasmic reticulum to Golgi vesicle-mediated transport; IBA:GO_Central.
DR   GO; GO:0009306; P:protein secretion; IBA:GO_Central.
DR   GO; GO:0035459; P:vesicle cargo loading; IBA:GO_Central.
DR   PANTHER; PTHR23158:SF57; CTAGE FAMILY MEMBER 15-RELATED; 1.
DR   PANTHER; PTHR23158; MELANOMA INHIBITORY ACTIVITY-RELATED; 1.
DR   Genevisible; P0CG41; HS.
PE   3: Inferred from homology;
KW   Coiled coil; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..777
FT                   /note="cTAGE family member 8"
FT                   /id="PRO_0000395454"
FT   TRANSMEM        39..59
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          510..673
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          721..742
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          118..269
FT                   /evidence="ECO:0000255"
FT   COILED          339..498
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        524..538
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        575..589
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        647..669
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   777 AA;  88077 MW;  CCB6B3DAFBF84D19 CRC64;
     MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW
     RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA
     AAEEARSLEA TCEKLNRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE
     SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGQVSE
     LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ
     WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ
     TQQASLQSEN IYFESENQKL QQKLKIMTEF YQENEMKLYR KLTVEENYRI EEEEKLSRVE
     EKISRATEGL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR
     KENAHNKQKL TETELKFELL EKDPNALDVS NTAFGREHSP CSPSPLGRPS SETRAFPSPQ
     TLLEDPLRLS PVLPGGGGRG PSSPGNPLDH QITNERGEPS YDRLIDPHRA PSDTGSLSSP
     VEQDRRMMFP PPGQSYPDST LPPQREDRFY SNSERLSGPA EPRSFKMTSL DKMDRSMPSE
     MESSRNDAKD DLGNLNVPDS SLPAENEATG PGFIPPPLAP VRGPLFPVDT RGPFMRRGPP
     FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYLHPRPG FYPNPTF
//