P0CG41 (CTGE8_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cutaneous T-cell lymphoma-associated antigen 8
Short name=Protein cTAGE-8

Gene names

Name:

CTAGE8

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	777 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Single-pass membrane protein Potential.
Sequence similarities	Belongs to the cTAGE family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Coiled coil Transmembrane Transmembrane helix
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 777	777	Cutaneous T-cell lymphoma-associated antigen 8		PRO_0000395454
Regions
	Transmembrane	39 – 59	21	Helical; Potential
	Coiled coil	118 – 269	152	Potential
	Coiled coil	339 – 498	160	Potential
	Compositional bias	691 – 775	85	Pro-rich

Sequences

	Sequence		Length	Mass (Da)
	P0CG41 [UniParc]. Last modified July 13, 2010. Version 1. Checksum: CCB6B3DAFBF84D19	FASTA	777	88,077
	10 20 30 40 50 60 MEEPGATPQP YLGLVLEELR RVVAALPESM RPDENPYGFP SELVVCAAVI GFFVVLLFLW 70 80 90 100 110 120 RSFRSVRSRL YVGREQKLGA TLSGLIEEKC KLLEKFSLIQ KEYEGYEVES SLEDASFEKA 130 140 150 160 170 180 AAEEARSLEA TCEKLNRSNS ELEDEILCLE KDLKEEKSKH SQQDELMADI SKSIQSLEDE 190 200 210 220 230 240 SKSLKSQIAE AKIICKTFKM SEERRAIAIK DALNENSQLQ TSHKQLFQQE AEVWKGQVSE 250 260 270 280 290 300 LNKQKITFED SKVHAEQVLN DKENHIKTLT GHLPMMKDQA AVLEEDTTDD DNLELEVNSQ 310 320 330 340 350 360 WENGANLDDP LKGALKKLIH AAKLNVSLKS LEGERNHIII QLSEVDKTKE ELTEHIKNLQ 370 380 390 400 410 420 TQQASLQSEN IYFESENQKL QQKLKIMTEF YQENEMKLYR KLTVEENYRI EEEEKLSRVE 430 440 450 460 470 480 EKISRATEGL ETYRKLAKDL EEELERTVHF YQKQVISYEK RGHDNWLAAR TAERNLSDLR 490 500 510 520 530 540 KENAHNKQKL TETELKFELL EKDPNALDVS NTAFGREHSP CSPSPLGRPS SETRAFPSPQ 550 560 570 580 590 600 TLLEDPLRLS PVLPGGGGRG PSSPGNPLDH QITNERGEPS YDRLIDPHRA PSDTGSLSSP 610 620 630 640 650 660 VEQDRRMMFP PPGQSYPDST LPPQREDRFY SNSERLSGPA EPRSFKMTSL DKMDRSMPSE 670 680 690 700 710 720 MESSRNDAKD DLGNLNVPDS SLPAENEATG PGFIPPPLAP VRGPLFPVDT RGPFMRRGPP 730 740 750 760 770 FPPPPPGTMF GASRGYFPPR DFPGPPHAPF AMRNIYPPRG LPPYLHPRPG FYPNPTF

References

[1]

"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC004889 Genomic DNA. No translation available.
IPI	IPI00969223.
UniGene	Hs.661442.
3D structure databases
ProteinModelPortal	P0CG41.
ModBase	Search...
PTM databases
PhosphoSite	P0CG41.
Polymorphism databases
DMDM	300680906.
Proteomic databases
PRIDE	P0CG41.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000487179; ENSP00000417289; ENSG00000244693.
Organism-specific databases
GeneCards	GC07M143963.
HGNC	HGNC:37294. CTAGE8.
HPA	HPA000387. HPA000922.
neXtProt	NX_P0CG41.
GenAtlas	Search...
Phylogenomic databases
OMA	LERELMV.
Gene expression databases
Bgee	P0CG41.
Family and domain databases
ProtoNet	Search...

Entry information

Entry name

CTGE8_HUMAN

Accession

Primary (citable) accession number: P0CG41

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 13, 2010
Last sequence update:	July 13, 2010
Last modified:	April 3, 2013
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.