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Protein

Transcription factor Sp9

Gene

SP9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transcription factor which plays a key role in limb development. Positively regulates FGF8 expression in the apical ectodermal ridge (AER) and contributes to limb outgrowth in embryos (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 356C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri362 – 386C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri392 – 414C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor Sp9
Gene namesi
Name:SP9
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000217236.1
HGNCiHGNC:30690 SP9
neXtProtiNX_P0CG40

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000217236
PharmGKBiPA164726207

Polymorphism and mutation databases

BioMutaiSP9
DMDMi300681123

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003954501 – 484Transcription factor Sp9Add BLAST484

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei440PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP0CG40
MaxQBiP0CG40
PaxDbiP0CG40
PeptideAtlasiP0CG40
PRIDEiP0CG40

PTM databases

iPTMnetiP0CG40
PhosphoSitePlusiP0CG40

Expressioni

Gene expression databases

BgeeiENSG00000217236

Organism-specific databases

HPAiHPA062616

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000378418

Structurei

3D structure databases

ProteinModelPortaliP0CG40
SMRiP0CG40
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 56Poly-Ser4
Compositional biasi113 – 120Poly-Ala8
Compositional biasi241 – 244Poly-Ala4
Compositional biasi272 – 299Ala-richAdd BLAST28
Compositional biasi452 – 478Ala-richAdd BLAST27

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri332 – 356C2H2-type 1PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri362 – 386C2H2-type 2PROSITE-ProRule annotationAdd BLAST25
Zinc fingeri392 – 414C2H2-type 3PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000118984
HOGENOMiHOG000231067
InParanoidiP0CG40
KOiK09199
OMAiHPYESWY
OrthoDBiEOG091G0HX6
PhylomeDBiP0CG40
TreeFamiTF350150

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 3 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 3 hits
PS50157 ZINC_FINGER_C2H2_2, 3 hits

Sequencei

Sequence statusi: Complete.

P0CG40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATSILGEEP RFGTTPLAML AATCNKIGNT SPLTTLPESS AFAKGGFHPW
60 70 80 90 100
KRSSSSCNLG SSLSGFAVAT GGRGSGGLAG GSGAANSAFC LASTSPTSSA
110 120 130 140 150
FSSDYGGLFS NSAAAAAAAA GVSPQEAGGQ SAFISKVHTT AADGLYPRVG
160 170 180 190 200
MAHPYESWYK SGFHSTLAAG EVTNGAASSW WDVHSSPGSW LEVQNPAGGL
210 220 230 240 250
QSSLHSGAPQ ASLHSQLGTY NPDFSSLTHS AFSSTGLGSS AAAASHLLST
260 270 280 290 300
SQHLLAQDGF KPVLPSYSDS SAAVAAAAAS AMISGAAAAA AGGSSARSAR
310 320 330 340 350
RYSGRATCDC PNCQEAERLG PAGASLRRKG LHSCHIPGCG KVYGKTSHLK
360 370 380 390 400
AHLRWHTGER PFVCNWLFCG KRFTRSDELQ RHLRTHTGEK RFACPVCNKR
410 420 430 440 450
FMRSDHLSKH IKTHNGGGGG KKGSDSDTDA SNLETPRSES PDLILHDSGV
460 470 480
SAARAAAAAA AAAAAAAAAA SAGGKEAASG PNDS
Length:484
Mass (Da):48,915
Last modified:July 13, 2010 - v1
Checksum:i4E6F06F8FE824A60
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC018470 Genomic DNA No translation available.
CH471058 Genomic DNA Translation: EAX11147.1
CCDSiCCDS46453.1
RefSeqiNP_001138722.1, NM_001145250.1
UniGeneiHs.516603

Genome annotation databases

EnsembliENST00000394967; ENSP00000378418; ENSG00000217236
GeneIDi100131390
KEGGihsa:100131390
UCSCiuc010zem.2 human

Similar proteinsi

Entry informationi

Entry nameiSP9_HUMAN
AccessioniPrimary (citable) accession number: P0CG40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: March 28, 2018
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health