ID   POTEJ_HUMAN             Reviewed;        1038 AA.
AC   P0CG39;
DT   13-JUL-2010, integrated into UniProtKB/Swiss-Prot.
DT   13-JUL-2010, sequence version 1.
DT   27-MAR-2024, entry version 100.
DE   RecName: Full=POTE ankyrin domain family member J;
GN   Name=POTEJ;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
CC   -!- SIMILARITY: In the N-terminal section; belongs to the POTE family.
CC       {ECO:0000305}.
CC   -!- SIMILARITY: In the C-terminal section; belongs to the actin family.
CC       {ECO:0000305}.
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DR   EMBL; AC140481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS59432.1; -.
DR   RefSeq; NP_001264012.1; NM_001277083.1.
DR   AlphaFoldDB; P0CG39; -.
DR   SMR; P0CG39; -.
DR   BioGRID; 576066; 52.
DR   IntAct; P0CG39; 8.
DR   MINT; P0CG39; -.
DR   STRING; 9606.ENSP00000387176; -.
DR   iPTMnet; P0CG39; -.
DR   PhosphoSitePlus; P0CG39; -.
DR   SwissPalm; P0CG39; -.
DR   BioMuta; POTEJ; -.
DR   DMDM; 300681052; -.
DR   EPD; P0CG39; -.
DR   jPOST; P0CG39; -.
DR   MassIVE; P0CG39; -.
DR   MaxQB; P0CG39; -.
DR   PaxDb; 9606-ENSP00000387176; -.
DR   PeptideAtlas; P0CG39; -.
DR   PRIDE; P0CG39; -.
DR   ProteomicsDB; 52469; -.
DR   Pumba; P0CG39; -.
DR   TopDownProteomics; P0CG39; -.
DR   Antibodypedia; 68638; 16 antibodies from 5 providers.
DR   DNASU; 653781; -.
DR   Ensembl; ENST00000409602.2; ENSP00000387176.1; ENSG00000222038.4.
DR   GeneID; 653781; -.
DR   KEGG; hsa:653781; -.
DR   MANE-Select; ENST00000409602.2; ENSP00000387176.1; NM_001277083.2; NP_001264012.1.
DR   UCSC; uc021vor.3; human.
DR   AGR; HGNC:37094; -.
DR   CTD; 653781; -.
DR   GeneCards; POTEJ; -.
DR   HGNC; HGNC:37094; POTEJ.
DR   HPA; ENSG00000222038; Not detected.
DR   neXtProt; NX_P0CG39; -.
DR   OpenTargets; ENSG00000222038; -.
DR   PharmGKB; PA165697368; -.
DR   VEuPathDB; HostDB:ENSG00000222038; -.
DR   eggNOG; KOG0676; Eukaryota.
DR   GeneTree; ENSGT00940000163068; -.
DR   HOGENOM; CLU_010163_0_0_1; -.
DR   InParanoid; P0CG39; -.
DR   OrthoDB; 4734228at2759; -.
DR   PhylomeDB; P0CG39; -.
DR   TreeFam; TF354237; -.
DR   PathwayCommons; P0CG39; -.
DR   SignaLink; P0CG39; -.
DR   BioGRID-ORCS; 653781; 227 hits in 1030 CRISPR screens.
DR   ChiTaRS; POTEJ; human.
DR   GenomeRNAi; 653781; -.
DR   Pharos; P0CG39; Tdark.
DR   PRO; PR:P0CG39; -.
DR   Proteomes; UP000005640; Chromosome 2.
DR   RNAct; P0CG39; Protein.
DR   Bgee; ENSG00000222038; Expressed in male germ line stem cell (sensu Vertebrata) in testis and 11 other cell types or tissues.
DR   GO; GO:0005884; C:actin filament; IBA:GO_Central.
DR   GO; GO:0030424; C:axon; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB.
DR   GO; GO:0005615; C:extracellular space; HDA:UniProtKB.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0019901; F:protein kinase binding; IBA:GO_Central.
DR   GO; GO:0098973; F:structural constituent of postsynaptic actin cytoskeleton; IBA:GO_Central.
DR   GO; GO:0007409; P:axonogenesis; IBA:GO_Central.
DR   GO; GO:0048870; P:cell motility; IBA:GO_Central.
DR   CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR   Gene3D; 3.30.420.40; -; 2.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR004000; Actin.
DR   InterPro; IPR020902; Actin/actin-like_CS.
DR   InterPro; IPR004001; Actin_CS.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR043129; ATPase_NBD.
DR   InterPro; IPR039497; CC144C-like_CC_dom.
DR   PANTHER; PTHR24147; ANKYRIN REPEAT DOMAIN 36-RELATED; 1.
DR   PANTHER; PTHR24147:SF66; POTE ANKYRIN DOMAIN FAMILY MEMBER D; 1.
DR   Pfam; PF00022; Actin; 1.
DR   Pfam; PF12796; Ank_2; 2.
DR   Pfam; PF14915; CCDC144C; 1.
DR   PRINTS; PR00190; ACTIN.
DR   SMART; SM00268; ACTIN; 1.
DR   SMART; SM00248; ANK; 6.
DR   SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
DR   PROSITE; PS00432; ACTINS_2; 1.
DR   PROSITE; PS01132; ACTINS_ACT_LIKE; 1.
DR   PROSITE; PS50297; ANK_REP_REGION; 1.
DR   PROSITE; PS50088; ANK_REPEAT; 4.
PE   3: Inferred from homology;
KW   ANK repeat; Coiled coil; Reference proteome; Repeat.
FT   CHAIN           1..1038
FT                   /note="POTE ankyrin domain family member J"
FT                   /id="PRO_0000395414"
FT   REPEAT          135..164
FT                   /note="ANK 1"
FT   REPEAT          168..197
FT                   /note="ANK 2"
FT   REPEAT          201..230
FT                   /note="ANK 3"
FT   REPEAT          234..263
FT                   /note="ANK 4"
FT   REPEAT          267..296
FT                   /note="ANK 5"
FT   REGION          332..493
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          507..561
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          666..1038
FT                   /note="Actin-like"
FT   COILED          605..661
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        341..356
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        366..388
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        423..447
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        459..493
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        546..561
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1038 AA;  117390 MW;  FFDFF97D149A0899 CRC64;
     MVAEVDSMPA ASSVKKPFVL RSKMGKWCRH CFPCCRGSGK SNVGTSGDQD DSTMKTLRSK
     MGKWCCHCFP CCRGSGKSNV GAWGDYDDSA FVEPRYHVRR EDLDKLHRAA WWGKVARKDL
     IVMLRDTDVN KQDKQKRTAL HLASANGNSG VVKLLLDRRC QLNVLDNKKR TALTKAVQCQ
     EDECALMLLE HGTDPNIPDE YGNTTLHYAI YNEDKLMAKA LLLYGADIES KNKHGLTPLL
     LGVHEQKQQV VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVSLLLEQ NIDVSSQDLS
     GQTAREYAVS SHHHVICQLL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES QRFKGSENSQ
     PEKMSQEPEI NKDGDREVEE EMKKHESNNV GLLENLSNGV TAGNGDDGLI PQRKSRTPEN
     QQFPDNESEE YHRICELVSD YKEKQMPKYS SENSNPEQDL KLTSEEESQR LKGSENGQPE
     KRSQEPEINK DGDRELENFM AIEEMKKHGS THVGFPENLT NGATAGNGDD GLIPPRKSRT
     PESQQFPDTE NEEYHSDEQN DTQKQFCEEQ NTGILHDEIL IHEEKQIEVV EKMNSELSLS
     CKKERDFLHE NSMLREEIAM LRLELDTMKH QSQLRKKKYL EDIESVKKKN DNLLKALQLN
     ELTMDDDTAV LVIDNGSGMC KAGFAGDDAP RAVFPSIVGC PRQQGMMGGM HQKESYVGKE
     AQSKRGILTL KYPMEHGIIT NWDDMEKIWH HTFYNELRVA PEEHPILLTE APLNPKANRE
     KMTQIMFETF NTPAMYVAIQ AMLSLYTSGR TTGIVMDSGD GVTHTVPIYD GNALPHATLR
     LDLAGRELTD YLMKILTERG YRFTTMAERE IVRDIKEKLC YVALDFEQEM AMVASSSSLE
     KSYELPDGQV ITISNEWFRC PEALFQPCFL GMESCGIHET TFNSIMKSDV DIRKDLYTNT
     VLSGGTTMYP GMAHRMQKEI AALAPSMMKI RIIAPPKRKY SVWVGGSILA SLSTFQQMWI
     SKQEYDESGP SIVHRKCF
//