Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

POTE ankyrin domain family member J

Gene

POTEJ

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  • retina homeostasis Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiP0CG39.

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member J
Gene namesi
Name:POTEJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:37094. POTEJ.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165697368.

Polymorphism and mutation databases

DMDMi300681052.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10381038POTE ankyrin domain family member JPRO_0000395414Add
BLAST

Proteomic databases

MaxQBiP0CG39.
PRIDEiP0CG39.

PTM databases

PhosphoSiteiP0CG39.

Expressioni

Gene expression databases

BgeeiP0CG39.

Organism-specific databases

HPAiHPA041264.
HPA041271.
HPA042822.
HPA043260.

Interactioni

Protein-protein interaction databases

BioGridi576066. 5 interactions.
IntActiP0CG39. 1 interaction.
STRINGi9606.ENSP00000387176.

Structurei

3D structure databases

ProteinModelPortaliP0CG39.
SMRiP0CG39. Positions 669-1038.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati135 – 16430ANK 1Add
BLAST
Repeati168 – 19730ANK 2Add
BLAST
Repeati201 – 23030ANK 3Add
BLAST
Repeati234 – 26330ANK 4Add
BLAST
Repeati267 – 29630ANK 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni666 – 1038373Actin-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili605 – 66157Sequence AnalysisAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the POTE family.Curated
In the C-terminal section; belongs to the actin family.Curated
Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

GeneTreeiENSGT00560000076605.
HOGENOMiHOG000115614.
InParanoidiP0CG39.
KOiK17299.
OrthoDBiEOG7FBRHS.
PhylomeDBiP0CG39.
TreeFamiTF354237.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00022. Actin. 1 hit.
PF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
SM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CG39-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAEVDSMPA ASSVKKPFVL RSKMGKWCRH CFPCCRGSGK SNVGTSGDQD
60 70 80 90 100
DSTMKTLRSK MGKWCCHCFP CCRGSGKSNV GAWGDYDDSA FVEPRYHVRR
110 120 130 140 150
EDLDKLHRAA WWGKVARKDL IVMLRDTDVN KQDKQKRTAL HLASANGNSG
160 170 180 190 200
VVKLLLDRRC QLNVLDNKKR TALTKAVQCQ EDECALMLLE HGTDPNIPDE
210 220 230 240 250
YGNTTLHYAI YNEDKLMAKA LLLYGADIES KNKHGLTPLL LGVHEQKQQV
260 270 280 290 300
VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVSLLLEQ NIDVSSQDLS
310 320 330 340 350
GQTAREYAVS SHHHVICQLL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES
360 370 380 390 400
QRFKGSENSQ PEKMSQEPEI NKDGDREVEE EMKKHESNNV GLLENLSNGV
410 420 430 440 450
TAGNGDDGLI PQRKSRTPEN QQFPDNESEE YHRICELVSD YKEKQMPKYS
460 470 480 490 500
SENSNPEQDL KLTSEEESQR LKGSENGQPE KRSQEPEINK DGDRELENFM
510 520 530 540 550
AIEEMKKHGS THVGFPENLT NGATAGNGDD GLIPPRKSRT PESQQFPDTE
560 570 580 590 600
NEEYHSDEQN DTQKQFCEEQ NTGILHDEIL IHEEKQIEVV EKMNSELSLS
610 620 630 640 650
CKKERDFLHE NSMLREEIAM LRLELDTMKH QSQLRKKKYL EDIESVKKKN
660 670 680 690 700
DNLLKALQLN ELTMDDDTAV LVIDNGSGMC KAGFAGDDAP RAVFPSIVGC
710 720 730 740 750
PRQQGMMGGM HQKESYVGKE AQSKRGILTL KYPMEHGIIT NWDDMEKIWH
760 770 780 790 800
HTFYNELRVA PEEHPILLTE APLNPKANRE KMTQIMFETF NTPAMYVAIQ
810 820 830 840 850
AMLSLYTSGR TTGIVMDSGD GVTHTVPIYD GNALPHATLR LDLAGRELTD
860 870 880 890 900
YLMKILTERG YRFTTMAERE IVRDIKEKLC YVALDFEQEM AMVASSSSLE
910 920 930 940 950
KSYELPDGQV ITISNEWFRC PEALFQPCFL GMESCGIHET TFNSIMKSDV
960 970 980 990 1000
DIRKDLYTNT VLSGGTTMYP GMAHRMQKEI AALAPSMMKI RIIAPPKRKY
1010 1020 1030
SVWVGGSILA SLSTFQQMWI SKQEYDESGP SIVHRKCF
Length:1,038
Mass (Da):117,390
Last modified:July 13, 2010 - v1
Checksum:iFFDFF97D149A0899
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140481 Genomic DNA. No translation available.
CCDSiCCDS59432.1.
RefSeqiNP_001264012.1. NM_001277083.1.
UniGeneiHs.558829.

Genome annotation databases

EnsembliENST00000409602; ENSP00000387176; ENSG00000222038.
GeneIDi653781.
KEGGihsa:653781.
UCSCiuc021vor.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC140481 Genomic DNA. No translation available.
CCDSiCCDS59432.1.
RefSeqiNP_001264012.1. NM_001277083.1.
UniGeneiHs.558829.

3D structure databases

ProteinModelPortaliP0CG39.
SMRiP0CG39. Positions 669-1038.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi576066. 5 interactions.
IntActiP0CG39. 1 interaction.
STRINGi9606.ENSP00000387176.

PTM databases

PhosphoSiteiP0CG39.

Polymorphism and mutation databases

DMDMi300681052.

Proteomic databases

MaxQBiP0CG39.
PRIDEiP0CG39.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000409602; ENSP00000387176; ENSG00000222038.
GeneIDi653781.
KEGGihsa:653781.
UCSCiuc021vor.2. human.

Organism-specific databases

CTDi653781.
GeneCardsiGC02P131370.
HGNCiHGNC:37094. POTEJ.
HPAiHPA041264.
HPA041271.
HPA042822.
HPA043260.
neXtProtiNX_P0CG39.
PharmGKBiPA165697368.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00560000076605.
HOGENOMiHOG000115614.
InParanoidiP0CG39.
KOiK17299.
OrthoDBiEOG7FBRHS.
PhylomeDBiP0CG39.
TreeFamiTF354237.

Enzyme and pathway databases

SignaLinkiP0CG39.

Miscellaneous databases

GenomeRNAii653781.
NextBioi123637.
PROiP0CG39.

Gene expression databases

BgeeiP0CG39.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00022. Actin. 1 hit.
PF00023. Ank. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
SM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPOTEJ_HUMAN
AccessioniPrimary (citable) accession number: P0CG39
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: July 22, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.