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P0CG39

- POTEJ_HUMAN

UniProt

P0CG39 - POTEJ_HUMAN

Protein

POTE ankyrin domain family member J

Gene

POTEJ

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. retina homeostasis Source: UniProt

    Enzyme and pathway databases

    SignaLinkiP0CG39.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POTE ankyrin domain family member J
    Gene namesi
    Name:POTEJ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:37094. POTEJ.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA165697368.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 10381038POTE ankyrin domain family member JPRO_0000395414Add
    BLAST

    Proteomic databases

    MaxQBiP0CG39.
    PRIDEiP0CG39.

    PTM databases

    PhosphoSiteiP0CG39.

    Expressioni

    Gene expression databases

    BgeeiP0CG39.

    Organism-specific databases

    HPAiHPA041264.
    HPA042822.
    HPA043260.

    Interactioni

    Protein-protein interaction databases

    BioGridi576066. 4 interactions.
    IntActiP0CG39. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CG39.
    SMRiP0CG39. Positions 10-327, 669-1038.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati135 – 16430ANK 1Add
    BLAST
    Repeati168 – 19730ANK 2Add
    BLAST
    Repeati201 – 23030ANK 3Add
    BLAST
    Repeati234 – 26330ANK 4Add
    BLAST
    Repeati267 – 29630ANK 5Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni666 – 1038373Actin-likeAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili605 – 66157Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the POTE family.Curated
    In the C-terminal section; belongs to the actin family.Curated
    Contains 5 ANK repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    ANK repeat, Coiled coil, Repeat

    Phylogenomic databases

    HOGENOMiHOG000115614.
    KOiK17299.
    OMAiNENCERI.
    OrthoDBiEOG7FBRHS.
    PhylomeDBiP0CG39.
    TreeFamiTF354237.

    Family and domain databases

    Gene3Di1.25.40.20. 1 hit.
    InterProiIPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view]
    PfamiPF00022. Actin. 1 hit.
    PF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    [Graphical view]
    PRINTSiPR00190. ACTIN.
    SMARTiSM00268. ACTIN. 1 hit.
    SM00248. ANK. 6 hits.
    [Graphical view]
    SUPFAMiSSF48403. SSF48403. 1 hit.
    PROSITEiPS00432. ACTINS_2. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CG39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVAEVDSMPA ASSVKKPFVL RSKMGKWCRH CFPCCRGSGK SNVGTSGDQD     50
    DSTMKTLRSK MGKWCCHCFP CCRGSGKSNV GAWGDYDDSA FVEPRYHVRR 100
    EDLDKLHRAA WWGKVARKDL IVMLRDTDVN KQDKQKRTAL HLASANGNSG 150
    VVKLLLDRRC QLNVLDNKKR TALTKAVQCQ EDECALMLLE HGTDPNIPDE 200
    YGNTTLHYAI YNEDKLMAKA LLLYGADIES KNKHGLTPLL LGVHEQKQQV 250
    VKFLIKKKAN LNALDRYGRT ALILAVCCGS ASIVSLLLEQ NIDVSSQDLS 300
    GQTAREYAVS SHHHVICQLL SDYKEKQMLK ISSENSNPEQ DLKLTSEEES 350
    QRFKGSENSQ PEKMSQEPEI NKDGDREVEE EMKKHESNNV GLLENLSNGV 400
    TAGNGDDGLI PQRKSRTPEN QQFPDNESEE YHRICELVSD YKEKQMPKYS 450
    SENSNPEQDL KLTSEEESQR LKGSENGQPE KRSQEPEINK DGDRELENFM 500
    AIEEMKKHGS THVGFPENLT NGATAGNGDD GLIPPRKSRT PESQQFPDTE 550
    NEEYHSDEQN DTQKQFCEEQ NTGILHDEIL IHEEKQIEVV EKMNSELSLS 600
    CKKERDFLHE NSMLREEIAM LRLELDTMKH QSQLRKKKYL EDIESVKKKN 650
    DNLLKALQLN ELTMDDDTAV LVIDNGSGMC KAGFAGDDAP RAVFPSIVGC 700
    PRQQGMMGGM HQKESYVGKE AQSKRGILTL KYPMEHGIIT NWDDMEKIWH 750
    HTFYNELRVA PEEHPILLTE APLNPKANRE KMTQIMFETF NTPAMYVAIQ 800
    AMLSLYTSGR TTGIVMDSGD GVTHTVPIYD GNALPHATLR LDLAGRELTD 850
    YLMKILTERG YRFTTMAERE IVRDIKEKLC YVALDFEQEM AMVASSSSLE 900
    KSYELPDGQV ITISNEWFRC PEALFQPCFL GMESCGIHET TFNSIMKSDV 950
    DIRKDLYTNT VLSGGTTMYP GMAHRMQKEI AALAPSMMKI RIIAPPKRKY 1000
    SVWVGGSILA SLSTFQQMWI SKQEYDESGP SIVHRKCF 1038
    Length:1,038
    Mass (Da):117,390
    Last modified:July 13, 2010 - v1
    Checksum:iFFDFF97D149A0899
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC140481 Genomic DNA. No translation available.
    CCDSiCCDS59432.1.
    RefSeqiNP_001264012.1. NM_001277083.1.
    UniGeneiHs.558829.

    Genome annotation databases

    EnsembliENST00000409602; ENSP00000387176; ENSG00000222038.
    GeneIDi653781.
    KEGGihsa:653781.
    UCSCiuc021vor.2. human.

    Polymorphism databases

    DMDMi300681052.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC140481 Genomic DNA. No translation available.
    CCDSi CCDS59432.1.
    RefSeqi NP_001264012.1. NM_001277083.1.
    UniGenei Hs.558829.

    3D structure databases

    ProteinModelPortali P0CG39.
    SMRi P0CG39. Positions 10-327, 669-1038.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 576066. 4 interactions.
    IntActi P0CG39. 1 interaction.

    PTM databases

    PhosphoSitei P0CG39.

    Polymorphism databases

    DMDMi 300681052.

    Proteomic databases

    MaxQBi P0CG39.
    PRIDEi P0CG39.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000409602 ; ENSP00000387176 ; ENSG00000222038 .
    GeneIDi 653781.
    KEGGi hsa:653781.
    UCSCi uc021vor.2. human.

    Organism-specific databases

    CTDi 653781.
    GeneCardsi GC02P131370.
    HGNCi HGNC:37094. POTEJ.
    HPAi HPA041264.
    HPA042822.
    HPA043260.
    neXtProti NX_P0CG39.
    PharmGKBi PA165697368.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000115614.
    KOi K17299.
    OMAi NENCERI.
    OrthoDBi EOG7FBRHS.
    PhylomeDBi P0CG39.
    TreeFami TF354237.

    Enzyme and pathway databases

    SignaLinki P0CG39.

    Miscellaneous databases

    GenomeRNAii 653781.
    NextBioi 123637.
    PROi P0CG39.

    Gene expression databases

    Bgeei P0CG39.

    Family and domain databases

    Gene3Di 1.25.40.20. 1 hit.
    InterProi IPR004000. Actin-related.
    IPR020902. Actin/actin-like_CS.
    IPR004001. Actin_CS.
    IPR002110. Ankyrin_rpt.
    IPR020683. Ankyrin_rpt-contain_dom.
    [Graphical view ]
    Pfami PF00022. Actin. 1 hit.
    PF00023. Ank. 1 hit.
    PF12796. Ank_2. 2 hits.
    [Graphical view ]
    PRINTSi PR00190. ACTIN.
    SMARTi SM00268. ACTIN. 1 hit.
    SM00248. ANK. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48403. SSF48403. 1 hit.
    PROSITEi PS00432. ACTINS_2. 1 hit.
    PS01132. ACTINS_ACT_LIKE. 1 hit.
    PS50297. ANK_REP_REGION. 1 hit.
    PS50088. ANK_REPEAT. 4 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiPOTEJ_HUMAN
    AccessioniPrimary (citable) accession number: P0CG39
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3