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Protein

POTE ankyrin domain family member I

Gene

POTEI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

GO - Biological processi

  • retina homeostasis Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiP0CG38.

Names & Taxonomyi

Protein namesi
Recommended name:
POTE ankyrin domain family member I
Gene namesi
Name:POTEI
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:37093. POTEI.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165697301.

Polymorphism and mutation databases

DMDMi300681051.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10751075POTE ankyrin domain family member IPRO_0000395413Add
BLAST

Proteomic databases

EPDiP0CG38.
MaxQBiP0CG38.
PaxDbiP0CG38.
PRIDEiP0CG38.
TopDownProteomicsiP0CG38.

PTM databases

iPTMnetiP0CG38.
PhosphoSiteiP0CG38.
SwissPalmiP0CG38.

Expressioni

Gene expression databases

BgeeiP0CG38.
ExpressionAtlasiP0CG38. baseline and differential.

Organism-specific databases

HPAiHPA041264.
HPA041271.
HPA042822.
HPA043260.

Interactioni

Protein-protein interaction databases

BioGridi575653. 32 interactions.
IntActiP0CG38. 1 interaction.
STRINGi9606.ENSP00000392718.

Structurei

3D structure databases

ProteinModelPortaliP0CG38.
SMRiP0CG38. Positions 706-1075.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati172 – 20130ANK 1Add
BLAST
Repeati205 – 23430ANK 2Add
BLAST
Repeati238 – 26730ANK 3Add
BLAST
Repeati271 – 30030ANK 4Add
BLAST
Repeati304 – 33330ANK 5Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni703 – 1075373Actin-likeAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili413 – 43624Sequence analysisAdd
BLAST
Coiled coili642 – 69857Sequence analysisAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the POTE family.Curated
In the C-terminal section; belongs to the actin family.Curated
Contains 5 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
KOG0676. Eukaryota.
COG0666. LUCA.
COG5277. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000115614.
InParanoidiP0CG38.
KOiK17299.
OMAiTIGNEWF.
OrthoDBiEOG7FBRHS.
PhylomeDBiP0CG38.
TreeFamiTF354237.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00022. Actin. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
SM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CG38-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVAEVDSMPA ASSVKKPFVL RSKMGKWCRH CFPCCRGSGK SNVGTSGDQD
60 70 80 90 100
DSTMKTLRSK MGKWCCHCFP CCRGSGKSNV GTSGDHDDSA MKTLRSKMGK
110 120 130 140 150
WCCHCFPCCR GSGKSNVGAW GDYDDSAFVE PRYHVRREDL DKLHRAAWWG
160 170 180 190 200
KVARKDLIVM LRDTDVNKQD KQKRTALHLA SANGNSGVVK LLLDRRCQLN
210 220 230 240 250
VLDNKKRTAL TKAVQCQEDE CALMLLEHGT DPNIPDEYGN TTLHYAIYNE
260 270 280 290 300
DKLMAKALLL YGADIESKNK HGLTPLLLGV HEQKQQVVKF LIKKKANLNA
310 320 330 340 350
LDRYGRTALI LAVCCGSASI VSLLLEQNID VSSQDLSGQT AREYAVSSHH
360 370 380 390 400
HVICQLLSDY KEKQMLKISS ENSNPEQDLK LTSEEESQRF KGSENSQPEK
410 420 430 440 450
MSQEPEINKD GDREVEEEMK KHESNNVGLL ENLSNGVTAG NGDDGLIPQR
460 470 480 490 500
KSRTPENQQF PDNESEEYHR ICELVSDYKE KQMPKYSSEN SNPEQDLKLT
510 520 530 540 550
SEEESQRLKG SENGQPEKRS QEPEINKDGD RELENFMAIE EMKKHGSTHV
560 570 580 590 600
GFPENLTNGA TAGNGDDGLI PPRKSRTPES QQFPDTENEE YHSDEQNDTQ
610 620 630 640 650
KQFCEEQNTG ILHDEILIHE EKQIEVVEKM NSELSLSCKK EKDFLHENST
660 670 680 690 700
LREEIAMLRL ELDTMKHQSQ LRKKKYLEDI ESVKKKNDNL LKALQLNELT
710 720 730 740 750
MDDDTAVLVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRQ QGMMGGMHQK
760 770 780 790 800
ESYVGKEAQS KRGILTLKYP MEHGIITNWD DMEKIWHHTF YNELRVAPEE
810 820 830 840 850
HPILLTEAPL NPKANREKMT QIMFETFNTP AMYVAIQAML SLYTSGRTTG
860 870 880 890 900
IVMDSGDGVT HTVPIYDGNA LPHATLRLDL AGRELTDYLM KILTERGYRF
910 920 930 940 950
TTMAEREIVR DIKEKLCYVA LDFEQEMAMA ASSSSLEKSY ELPDGQVITI
960 970 980 990 1000
GNEWFRCPEA LFQPCFLGME SCGIHETTFN SIMKSDVDIR KDLYTNTVLS
1010 1020 1030 1040 1050
GGTTMYPGMA HRMQKEIAAL APSMLKIRII APPKRKYSVW VGGSILASLS
1060 1070
TFQQMWISKQ EYDESGPSIV HRKCF
Length:1,075
Mass (Da):121,282
Last modified:July 13, 2010 - v1
Checksum:iB85717179453DCBA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013269 Genomic DNA. No translation available.
CCDSiCCDS59431.1.
RefSeqiNP_001264335.1. NM_001277406.1.
UniGeneiHs.558782.

Genome annotation databases

EnsembliENST00000451531; ENSP00000392718; ENSG00000196834.
GeneIDi653269.
KEGGihsa:653269.
UCSCiuc031rpa.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013269 Genomic DNA. No translation available.
CCDSiCCDS59431.1.
RefSeqiNP_001264335.1. NM_001277406.1.
UniGeneiHs.558782.

3D structure databases

ProteinModelPortaliP0CG38.
SMRiP0CG38. Positions 706-1075.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi575653. 32 interactions.
IntActiP0CG38. 1 interaction.
STRINGi9606.ENSP00000392718.

PTM databases

iPTMnetiP0CG38.
PhosphoSiteiP0CG38.
SwissPalmiP0CG38.

Polymorphism and mutation databases

DMDMi300681051.

Proteomic databases

EPDiP0CG38.
MaxQBiP0CG38.
PaxDbiP0CG38.
PRIDEiP0CG38.
TopDownProteomicsiP0CG38.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000451531; ENSP00000392718; ENSG00000196834.
GeneIDi653269.
KEGGihsa:653269.
UCSCiuc031rpa.2. human.

Organism-specific databases

CTDi653269.
GeneCardsiPOTEI.
HGNCiHGNC:37093. POTEI.
HPAiHPA041264.
HPA041271.
HPA042822.
HPA043260.
neXtProtiNX_P0CG38.
PharmGKBiPA165697301.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410ITJG. Eukaryota.
KOG0676. Eukaryota.
COG0666. LUCA.
COG5277. LUCA.
GeneTreeiENSGT00560000076605.
HOGENOMiHOG000115614.
InParanoidiP0CG38.
KOiK17299.
OMAiTIGNEWF.
OrthoDBiEOG7FBRHS.
PhylomeDBiP0CG38.
TreeFamiTF354237.

Enzyme and pathway databases

SignaLinkiP0CG38.

Miscellaneous databases

GenomeRNAii653269.
PROiP0CG38.

Gene expression databases

BgeeiP0CG38.
ExpressionAtlasiP0CG38. baseline and differential.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR004000. Actin.
IPR020902. Actin/actin-like_CS.
IPR004001. Actin_CS.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF00022. Actin. 1 hit.
PF12796. Ank_2. 2 hits.
[Graphical view]
PRINTSiPR00190. ACTIN.
SMARTiSM00268. ACTIN. 1 hit.
SM00248. ANK. 6 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS00432. ACTINS_2. 1 hit.
PS01132. ACTINS_ACT_LIKE. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiPOTEI_HUMAN
AccessioniPrimary (citable) accession number: P0CG38
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: June 8, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.