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P0CG36

- CFC1B_HUMAN

UniProt

P0CG36 - CFC1B_HUMAN

Protein

Cryptic family protein 1B

Gene

CFC1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (13 Jul 2010)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. gastrulation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Gastrulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cryptic family protein 1B
    Gene namesi
    Name:CFC1B
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:33983. CFC1B.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162382207.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2525Sequence AnalysisAdd
    BLAST
    Chaini26 – 223198Cryptic family protein 1BPRO_0000395408Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi90 ↔ 97PROSITE-ProRule annotation
    Disulfide bondi91 ↔ 103PROSITE-ProRule annotation
    Disulfide bondi105 ↔ 114PROSITE-ProRule annotation

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP0CG36.

    Expressioni

    Gene expression databases

    BgeeiP0CG36.

    Organism-specific databases

    HPAiHPA041773.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CG36.
    SMRiP0CG36. Positions 89-116.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini86 – 11530EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 EGF-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal

    Phylogenomic databases

    HOGENOMiHOG000090236.
    OMAiIHLGNSY.
    OrthoDBiEOG7TJ3KK.
    PhylomeDBiP0CG36.
    TreeFamiTF333187.

    Family and domain databases

    InterProiIPR019011. Cryptic/Cripto_CFC-dom.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    [Graphical view]
    PfamiPF09443. CFC. 1 hit.
    [Graphical view]
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P0CG36-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTWRHHVRLL FTVSLALQII NLGNSYQREK HNGGREEVTK VATQKHRQSP    50
    LNWTSSHFGE VTGSAEGWGP EEPLPYSWAF GEGASARPRC CRNGGTCVLG 100
    SFCVCPAHFT GRYCEHDQRR SECGALEHGA WTLRACHLCR CIFGALHCLP 150
    LQTPDRCDPK DFLASHAHGP SAGGAPSLLL LLPCALLHRL LRPDAPAHPR 200
    SLVPSVLQRE RRPCGRPGLG HRL 223
    Length:223
    Mass (Da):24,642
    Last modified:July 13, 2010 - v1
    Checksum:i457EB443BC0CF1A5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC013269 Genomic DNA. Translation: AAY14955.1.
    CCDSiCCDS33286.1.
    RefSeqiNP_001072998.1. NM_001079530.1.
    UniGeneiHs.503733.

    Genome annotation databases

    EnsembliENST00000281882; ENSP00000281882; ENSG00000152093.
    GeneIDi653275.
    KEGGihsa:653275.
    UCSCiuc002trl.2. human.

    Polymorphism databases

    DMDMi300680885.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC013269 Genomic DNA. Translation: AAY14955.1 .
    CCDSi CCDS33286.1.
    RefSeqi NP_001072998.1. NM_001079530.1.
    UniGenei Hs.503733.

    3D structure databases

    ProteinModelPortali P0CG36.
    SMRi P0CG36. Positions 89-116.
    ModBasei Search...
    MobiDBi Search...

    Polymorphism databases

    DMDMi 300680885.

    Proteomic databases

    PRIDEi P0CG36.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000281882 ; ENSP00000281882 ; ENSG00000152093 .
    GeneIDi 653275.
    KEGGi hsa:653275.
    UCSCi uc002trl.2. human.

    Organism-specific databases

    CTDi 653275.
    GeneCardsi GC02P131278.
    HGNCi HGNC:33983. CFC1B.
    HPAi HPA041773.
    neXtProti NX_P0CG36.
    PharmGKBi PA162382207.
    GenAtlasi Search...

    Phylogenomic databases

    HOGENOMi HOG000090236.
    OMAi IHLGNSY.
    OrthoDBi EOG7TJ3KK.
    PhylomeDBi P0CG36.
    TreeFami TF333187.

    Miscellaneous databases

    ChiTaRSi CFC1B. human.
    GeneWikii Cripto.
    GenomeRNAii 653275.
    NextBioi 123026.

    Gene expression databases

    Bgeei P0CG36.

    Family and domain databases

    InterProi IPR019011. Cryptic/Cripto_CFC-dom.
    IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    [Graphical view ]
    Pfami PF09443. CFC. 1 hit.
    [Graphical view ]
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiCFC1B_HUMAN
    AccessioniPrimary (citable) accession number: P0CG36
    Secondary accession number(s): B2RCY0
    , B9EJD3, Q53T05, Q9GZR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 13, 2010
    Last sequence update: July 13, 2010
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    This gene differs from CFC1 by only one residue at position 78:R -> W. R78W is also thought to be a CFC1 polymorphism.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3