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P0CG36

- CFC1B_HUMAN

UniProt

P0CG36 - CFC1B_HUMAN

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Protein

Cryptic family protein 1B

Gene

CFC1B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

GO - Biological processi

  1. gastrulation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Gastrulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cryptic family protein 1B
Gene namesi
Name:CFC1B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:33983. CFC1B.

Subcellular locationi

Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162382207.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Sequence AnalysisAdd
BLAST
Chaini26 – 223198Cryptic family protein 1BPRO_0000395408Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi52 – 521N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi90 ↔ 97PROSITE-ProRule annotation
Disulfide bondi91 ↔ 103PROSITE-ProRule annotation
Disulfide bondi105 ↔ 114PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP0CG36.

Expressioni

Gene expression databases

BgeeiP0CG36.

Organism-specific databases

HPAiHPA041773.

Structurei

3D structure databases

ProteinModelPortaliP0CG36.
SMRiP0CG36. Positions 83-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini86 – 11530EGF-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal

Phylogenomic databases

GeneTreeiENSGT00530000063804.
HOGENOMiHOG000090236.
InParanoidiP0CG36.
OMAiIHLGNSY.
OrthoDBiEOG7TJ3KK.
PhylomeDBiP0CG36.
TreeFamiTF333187.

Family and domain databases

InterProiIPR019011. Cryptic/Cripto_CFC-dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
PfamiPF09443. CFC. 1 hit.
[Graphical view]
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CG36-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTWRHHVRLL FTVSLALQII NLGNSYQREK HNGGREEVTK VATQKHRQSP
60 70 80 90 100
LNWTSSHFGE VTGSAEGWGP EEPLPYSWAF GEGASARPRC CRNGGTCVLG
110 120 130 140 150
SFCVCPAHFT GRYCEHDQRR SECGALEHGA WTLRACHLCR CIFGALHCLP
160 170 180 190 200
LQTPDRCDPK DFLASHAHGP SAGGAPSLLL LLPCALLHRL LRPDAPAHPR
210 220
SLVPSVLQRE RRPCGRPGLG HRL
Length:223
Mass (Da):24,642
Last modified:July 13, 2010 - v1
Checksum:i457EB443BC0CF1A5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013269 Genomic DNA. Translation: AAY14955.1.
CCDSiCCDS33286.1.
RefSeqiNP_001072998.1. NM_001079530.1.
UniGeneiHs.503733.

Genome annotation databases

EnsembliENST00000281882; ENSP00000281882; ENSG00000152093.
GeneIDi653275.
KEGGihsa:653275.
UCSCiuc002trl.2. human.

Polymorphism databases

DMDMi300680885.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC013269 Genomic DNA. Translation: AAY14955.1 .
CCDSi CCDS33286.1.
RefSeqi NP_001072998.1. NM_001079530.1.
UniGenei Hs.503733.

3D structure databases

ProteinModelPortali P0CG36.
SMRi P0CG36. Positions 83-145.
ModBasei Search...
MobiDBi Search...

Polymorphism databases

DMDMi 300680885.

Proteomic databases

PRIDEi P0CG36.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000281882 ; ENSP00000281882 ; ENSG00000152093 .
GeneIDi 653275.
KEGGi hsa:653275.
UCSCi uc002trl.2. human.

Organism-specific databases

CTDi 653275.
GeneCardsi GC02P131278.
HGNCi HGNC:33983. CFC1B.
HPAi HPA041773.
neXtProti NX_P0CG36.
PharmGKBi PA162382207.
GenAtlasi Search...

Phylogenomic databases

GeneTreei ENSGT00530000063804.
HOGENOMi HOG000090236.
InParanoidi P0CG36.
OMAi IHLGNSY.
OrthoDBi EOG7TJ3KK.
PhylomeDBi P0CG36.
TreeFami TF333187.

Miscellaneous databases

ChiTaRSi CFC1B. human.
GeneWikii Cripto.
GenomeRNAii 653275.
NextBioi 123026.

Gene expression databases

Bgeei P0CG36.

Family and domain databases

InterProi IPR019011. Cryptic/Cripto_CFC-dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view ]
Pfami PF09443. CFC. 1 hit.
[Graphical view ]
SMARTi SM00181. EGF. 1 hit.
[Graphical view ]
PROSITEi PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiCFC1B_HUMAN
AccessioniPrimary (citable) accession number: P0CG36
Secondary accession number(s): B2RCY0
, B9EJD3, Q53T05, Q9GZR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: October 29, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

This gene differs from CFC1 by only one residue at position 78:R -> W. R78W is also thought to be a CFC1 polymorphism.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3