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P0CG36 (CFC1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cryptic family protein 1B
Gene names
Name:CFC1B
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length223 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existencePredicted

General annotation (Comments)

Subcellular location

Secreted Potential.

Sequence similarities

Contains 1 EGF-like domain.

Caution

This gene differs from CFC1 by only one residue at position 78:R -> W. R78W is also thought to be a CFC1 polymorphism.

Ontologies

Keywords
   Biological processGastrulation
   Cellular componentSecreted
   DomainEGF-like domain
Signal
   Molecular functionDevelopmental protein
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processgastrulation

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2525 Potential
Chain26 – 223198Cryptic family protein 1B
PRO_0000395408

Regions

Domain86 – 11530EGF-like

Amino acid modifications

Glycosylation521N-linked (GlcNAc...) Potential
Disulfide bond90 ↔ 97 By similarity
Disulfide bond91 ↔ 103 By similarity
Disulfide bond105 ↔ 114 By similarity

Sequences

Sequence LengthMass (Da)Tools
P0CG36 [UniParc].

Last modified July 13, 2010. Version 1.
Checksum: 457EB443BC0CF1A5

FASTA22324,642
        10         20         30         40         50         60 
MTWRHHVRLL FTVSLALQII NLGNSYQREK HNGGREEVTK VATQKHRQSP LNWTSSHFGE 

        70         80         90        100        110        120 
VTGSAEGWGP EEPLPYSWAF GEGASARPRC CRNGGTCVLG SFCVCPAHFT GRYCEHDQRR 

       130        140        150        160        170        180 
SECGALEHGA WTLRACHLCR CIFGALHCLP LQTPDRCDPK DFLASHAHGP SAGGAPSLLL 

       190        200        210        220 
LLPCALLHRL LRPDAPAHPR SLVPSVLQRE RRPCGRPGLG HRL 

« Hide

References

[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC013269 Genomic DNA. Translation: AAY14955.1.
CCDSCCDS33286.1.
RefSeqNP_001072998.1. NM_001079530.1.
UniGeneHs.503733.

3D structure databases

ProteinModelPortalP0CG36.
SMRP0CG36. Positions 89-116.
ModBaseSearch...
MobiDBSearch...

Polymorphism databases

DMDM300680885.

Proteomic databases

PRIDEP0CG36.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000281882; ENSP00000281882; ENSG00000152093.
GeneID653275.
KEGGhsa:653275.
UCSCuc002trl.2. human.

Organism-specific databases

CTD653275.
GeneCardsGC02P131278.
HGNCHGNC:33983. CFC1B.
HPAHPA041773.
neXtProtNX_P0CG36.
PharmGKBPA162382207.
GenAtlasSearch...

Phylogenomic databases

HOGENOMHOG000090236.
OMAIHLGNSY.
OrthoDBEOG7TJ3KK.
PhylomeDBP0CG36.
TreeFamTF333187.

Gene expression databases

BgeeP0CG36.

Family and domain databases

InterProIPR019011. Cryptic/Cripto_CFC-dom.
IPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
[Graphical view]
PfamPF09443. CFC. 1 hit.
[Graphical view]
SMARTSM00181. EGF. 1 hit.
[Graphical view]
PROSITEPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSCFC1B. human.
GeneWikiCripto.
GenomeRNAi653275.
NextBio123026.

Entry information

Entry nameCFC1B_HUMAN
AccessionPrimary (citable) accession number: P0CG36
Secondary accession number(s): B2RCY0 expand/collapse secondary AC list , B9EJD3, Q53T05, Q9GZR3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: July 9, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 2

Human chromosome 2: entries, gene names and cross-references to MIM