P0CG36 (CFC1B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cryptic family protein 1B

Gene names

Name:

CFC1B

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	223 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Predicted

General annotation (Comments)

Subcellular location	Secreted Potential.
Sequence similarities	Contains 1 EGF-like domain.
Caution	This gene differs from CFC1 by only one residue at position 78:R -> W. R78W is also thought to be a CFC1 polymorphism.

Ontologies

Keywords
Biological process	Gastrulation
Cellular component	Secreted
Domain	EGF-like domain Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	gastrulation Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 25	25	Potential
	Chain	26 – 223	198	Cryptic family protein 1B		PRO_0000395408
Regions
	Domain	86 – 115	30	EGF-like
Amino acid modifications
	Glycosylation	52	1	N-linked (GlcNAc...) Potential
	Disulfide bond	90 ↔ 97		By similarity
	Disulfide bond	91 ↔ 103		By similarity
	Disulfide bond	105 ↔ 114		By similarity

Sequences

	Sequence		Length	Mass (Da)
	P0CG36 [UniParc]. Last modified July 13, 2010. Version 1. Checksum: 457EB443BC0CF1A5	FASTA	223	24,642
	10 20 30 40 50 60 MTWRHHVRLL FTVSLALQII NLGNSYQREK HNGGREEVTK VATQKHRQSP LNWTSSHFGE 70 80 90 100 110 120 VTGSAEGWGP EEPLPYSWAF GEGASARPRC CRNGGTCVLG SFCVCPAHFT GRYCEHDQRR 130 140 150 160 170 180 SECGALEHGA WTLRACHLCR CIFGALHCLP LQTPDRCDPK DFLASHAHGP SAGGAPSLLL 190 200 210 220 LLPCALLHRL LRPDAPAHPR SLVPSVLQRE RRPCGRPGLG HRL

References

[1]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC013269 Genomic DNA. Translation: AAY14955.1.
IPI	IPI00737168.
RefSeq	NP_001072998.1. NM_001079530.1.
UniGene	Hs.503733.
3D structure databases
ProteinModelPortal	P0CG36.
SMR	P0CG36. Positions 59-158.
ModBase	Search...
Polymorphism databases
DMDM	300680885.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000281882; ENSP00000281882; ENSG00000152093.
GeneID	653275.
KEGG	hsa:653275.
UCSC	uc002tro.1. human.
Organism-specific databases
CTD	653275.
GeneCards	GC02P131278.
HGNC	HGNC:33983. CFC1B.
HPA	HPA041773.
neXtProt	NX_P0CG36.
PharmGKB	PA162382207.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000090236.
OMA	GCHLCRC.
OrthoDB	EOG4CZBHB.
PhylomeDB	P0CG36.
Gene expression databases
Bgee	P0CG36.
Family and domain databases
InterPro	IPR019011. Cryptic/Cripto_CFC-dom. IPR000742. EG-like_dom. IPR013032. EGF-like_CS. [Graphical view]
Pfam	PF09443. CFC. 1 hit. [Graphical view]
SMART	SM00181. EGF. 1 hit. [Graphical view]
PROSITE	PS00022. EGF_1. 1 hit. PS01186. EGF_2. False negative. PS50026. EGF_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	CFC1B. human.
GenomeRNAi	653275.
NextBio	123026.

Entry information

Entry name

CFC1B_HUMAN

Accession

Primary (citable) accession number: P0CG36
Secondary accession number(s): B2RCY0 , B9EJD3, Q53T05, Q9GZR3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 13, 2010
Last sequence update:	July 13, 2010
Last modified:	April 3, 2013
This is version 23 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.