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Protein

Putative zinc finger protein 286B

Gene

ZNF286B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri244 – 26623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Putative zinc finger protein 286B
Gene namesi
Name:ZNF286B
Synonyms:ZNF286C, ZNF286L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:33241. ZNF286B.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA162410081.

Polymorphism and mutation databases

BioMutaiZNF286B.
DMDMi300681206.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 522522Putative zinc finger protein 286BPRO_0000395360Add
BLAST

Proteomic databases

MaxQBiP0CG31.
PaxDbiP0CG31.
PRIDEiP0CG31.

PTM databases

iPTMnetiP0CG31.
PhosphoSiteiP0CG31.

Expressioni

Gene expression databases

BgeeiP0CG31.
ExpressionAtlasiP0CG31. baseline and differential.
GenevisibleiP0CG31. HS.

Organism-specific databases

HPAiHPA068125.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000461413.

Structurei

3D structure databases

ProteinModelPortaliP0CG31.
SMRiP0CG31. Positions 175-517.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 10 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri244 – 26623C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri272 – 29423C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri299 – 32123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 34923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri355 – 37723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri383 – 40523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri411 – 43323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri439 – 46123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri467 – 48923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri495 – 51723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
InParanoidiP0CG31.
OMAiAVECESW.
PhylomeDBiP0CG31.
TreeFamiTF337055.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CG31-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METDLAEMPE KGVLSSQDSP HFQEKSTEEG EVAALRLTAR SQAAAAAAAP
60 70 80 90 100
GSRSLRGVHV PPPLHPAPAR EEIKSTCSLK ACFSLSLTLT YYRTAFLLST
110 120 130 140 150
ENEGNLHFQC PSDVETRPQS KDSTSVQDFS KAESCKVAII DRLTRNSVYD
160 170 180 190 200
SNLEAALECE NWLEKQQGNQ ERHLREMFTH MNSLSEETDH EHDVYWKSFN
210 220 230 240 250
QKSVLITEDR VPKGSYAFHT LEKSLKQKSN LMKKQRTYKE KKPHKCNDCG
260 270 280 290 300
ELFTCHSVHI QHQRVHTGEK PYTCNECGKS FSHRANLTKH QRTHTRILFE
310 320 330 340 350
CRECKKTFTE SSSLATHQRI HVGERPYECN ECGKGFNRST HLVQHQLIHT
360 370 380 390 400
GVRPYECNEC DKAFIHSSAL IKHQRTHTGE KPYKCQECGK AFSHCSSLTK
410 420 430 440 450
HQRVHTGEKP YECSECGKTF SQSTHLVQHQ RIHTGEKPYE CSECGKTFSQ
460 470 480 490 500
SSNFAKHQRI HIGKKPYKCS ECGKAFIHSS ALIQHQRTHT GEKPFRCNEC
510 520
GKSFKCSSSL IRHQRVHTEE QP
Length:522
Mass (Da):59,572
Last modified:July 13, 2010 - v1
Checksum:iD1818B9F64EE43D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026271 Genomic DNA. No translation available.
CCDSiCCDS58523.1.
RefSeqiNP_001138517.1. NM_001145045.1.
UniGeneiHs.534279.

Genome annotation databases

EnsembliENST00000545289; ENSP00000461413; ENSG00000249459.
GeneIDi729288.
KEGGihsa:729288.
UCSCiuc010vyd.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026271 Genomic DNA. No translation available.
CCDSiCCDS58523.1.
RefSeqiNP_001138517.1. NM_001145045.1.
UniGeneiHs.534279.

3D structure databases

ProteinModelPortaliP0CG31.
SMRiP0CG31. Positions 175-517.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000461413.

PTM databases

iPTMnetiP0CG31.
PhosphoSiteiP0CG31.

Polymorphism and mutation databases

BioMutaiZNF286B.
DMDMi300681206.

Proteomic databases

MaxQBiP0CG31.
PaxDbiP0CG31.
PRIDEiP0CG31.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000545289; ENSP00000461413; ENSG00000249459.
GeneIDi729288.
KEGGihsa:729288.
UCSCiuc010vyd.3. human.

Organism-specific databases

CTDi729288.
GeneCardsiZNF286B.
HGNCiHGNC:33241. ZNF286B.
HPAiHPA068125.
neXtProtiNX_P0CG31.
PharmGKBiPA162410081.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1721. Eukaryota.
COG5048. LUCA.
GeneTreeiENSGT00840000129762.
InParanoidiP0CG31.
OMAiAVECESW.
PhylomeDBiP0CG31.
TreeFamiTF337055.

Miscellaneous databases

ChiTaRSiZNF286B. human.
GenomeRNAii729288.
NextBioi129793.

Gene expression databases

BgeeiP0CG31.
ExpressionAtlasiP0CG31. baseline and differential.
GenevisibleiP0CG31. HS.

Family and domain databases

Gene3Di3.30.160.60. 10 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 5 hits.
PF13465. zf-H2C2_2. 1 hit.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 10 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 10 hits.
PS50157. ZINC_FINGER_C2H2_2. 10 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiZ286B_HUMAN
AccessioniPrimary (citable) accession number: P0CG31
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: May 11, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.