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Protein

Glutathione S-transferase theta-2B

Gene

GSTT2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

  • glutathione transferase activity Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

BRENDAi2.5.1.18. 2681.
ReactomeiR-HSA-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-2B (EC:2.5.1.18)
Alternative name(s):
GST class-theta-2
Glutathione S-transferase theta-2
Gene namesi
Name:GSTT2B
Synonyms:GSTT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:33437. GSTT2B.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi653689.
OpenTargetsiENSG00000133433.
ENSG00000278695.
PharmGKBiPA162390358.

Polymorphism and mutation databases

BioMutaiGSTT2B.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00003953442 – 244Glutathione S-transferase theta-2BAdd BLAST243

Proteomic databases

EPDiP0CG30.
MaxQBiP0CG30.
PaxDbiP0CG30.
PeptideAtlasiP0CG30.
PRIDEiP0CG30.

PTM databases

iPTMnetiP0CG30.
PhosphoSitePlusiP0CG30.

Expressioni

Tissue specificityi

Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.1 Publication

Gene expression databases

BgeeiENSG00000133433.
ExpressionAtlasiP0CG30. baseline and differential.
GenevisibleiP0CG30. HS.

Organism-specific databases

HPAiHPA000750.

Interactioni

Subunit structurei

Homodimer.1 Publication

Protein-protein interaction databases

BioGridi109208. 2 interactors.
575985. 5 interactors.
STRINGi9606.ENSP00000290765.

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi12 – 23Combined sources12
Beta strandi28 – 32Combined sources5
Turni35 – 38Combined sources4
Helixi39 – 41Combined sources3
Helixi43 – 46Combined sources4
Beta strandi56 – 59Combined sources4
Beta strandi62 – 65Combined sources4
Helixi67 – 77Combined sources11
Helixi82 – 84Combined sources3
Helixi89 – 105Combined sources17
Turni106 – 111Combined sources6
Helixi112 – 117Combined sources6
Helixi119 – 122Combined sources4
Helixi129 – 148Combined sources20
Turni149 – 153Combined sources5
Beta strandi154 – 156Combined sources3
Beta strandi159 – 161Combined sources3
Helixi164 – 178Combined sources15
Turni183 – 186Combined sources4
Helixi188 – 201Combined sources14
Helixi203 – 222Combined sources20
Helixi230 – 241Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LJRX-ray3.20A/B1-244[»]
2LJRX-ray3.20A/B1-244[»]
3LJRX-ray3.30A/B1-244[»]
4MPGX-ray1.95A/B1-244[»]
ProteinModelPortaliP0CG30.
SMRiP0CG30.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CG30.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 82GST N-terminalAdd BLAST81
Domaini88 – 224GST C-terminalAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni40 – 41Glutathione binding2
Regioni53 – 54Glutathione binding2
Regioni66 – 67Glutathione binding2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00540000069741.
InParanoidiP0CG30.
KOiK00799.
OMAiHAYNIRS.
OrthoDBiEOG091G0PCG.
PhylomeDBiP0CG30.
TreeFamiTF325759.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CG30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS
60 70 80 90 100
LGKLPTLKDG DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG
110 120 130 140 150
WHADCIRGTF GIPLWVQVLG PLIGVQVPEE KVERNRTAMD QALQWLEDKF
160 170 180 190 200
LGDRPFLAGQ QVTLADLMAL EELMQPVALG YELFEGRPRL AAWRGRVEAF
210 220 230 240
LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI ARIP
Length:244
Mass (Da):27,507
Last modified:July 13, 2010 - v1
Checksum:iDBAF5D00F8C2FFC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2G → V AA sequence (PubMed:1417752).Curated1
Sequence conflicti156 – 158FLA → P in AAC13317 (Ref. 2) Curated3

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_033982139M → I.1 PublicationCorresponds to variant rs1622002dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38503 mRNA. Translation: AAB63956.1.
AF057176
, AF057173, AF057174, AF057175 Genomic DNA. Translation: AAC13317.1.
CR456500 mRNA. Translation: CAG30386.1.
AP000350 Genomic DNA. No translation available.
BC002415 mRNA. Translation: AAH02415.1.
CCDSiCCDS33617.1.
PIRiA56847.
RefSeqiNP_001074312.1. NM_001080843.3.
UniGeneiHs.654462.
Hs.656498.

Genome annotation databases

EnsembliENST00000290765; ENSP00000290765; ENSG00000133433.
ENST00000616938; ENSP00000478389; ENSG00000278695.
GeneIDi653689.
KEGGihsa:653689.
UCSCiuc002zyw.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38503 mRNA. Translation: AAB63956.1.
AF057176
, AF057173, AF057174, AF057175 Genomic DNA. Translation: AAC13317.1.
CR456500 mRNA. Translation: CAG30386.1.
AP000350 Genomic DNA. No translation available.
BC002415 mRNA. Translation: AAH02415.1.
CCDSiCCDS33617.1.
PIRiA56847.
RefSeqiNP_001074312.1. NM_001080843.3.
UniGeneiHs.654462.
Hs.656498.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LJRX-ray3.20A/B1-244[»]
2LJRX-ray3.20A/B1-244[»]
3LJRX-ray3.30A/B1-244[»]
4MPGX-ray1.95A/B1-244[»]
ProteinModelPortaliP0CG30.
SMRiP0CG30.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109208. 2 interactors.
575985. 5 interactors.
STRINGi9606.ENSP00000290765.

PTM databases

iPTMnetiP0CG30.
PhosphoSitePlusiP0CG30.

Polymorphism and mutation databases

BioMutaiGSTT2B.

Proteomic databases

EPDiP0CG30.
MaxQBiP0CG30.
PaxDbiP0CG30.
PeptideAtlasiP0CG30.
PRIDEiP0CG30.

Protocols and materials databases

DNASUi2953.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290765; ENSP00000290765; ENSG00000133433.
ENST00000616938; ENSP00000478389; ENSG00000278695.
GeneIDi653689.
KEGGihsa:653689.
UCSCiuc002zyw.5. human.

Organism-specific databases

CTDi653689.
DisGeNETi653689.
GeneCardsiGSTT2B.
HGNCiHGNC:33437. GSTT2B.
HPAiHPA000750.
neXtProtiNX_P0CG30.
OpenTargetsiENSG00000133433.
ENSG00000278695.
PharmGKBiPA162390358.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
GeneTreeiENSGT00540000069741.
InParanoidiP0CG30.
KOiK00799.
OMAiHAYNIRS.
OrthoDBiEOG091G0PCG.
PhylomeDBiP0CG30.
TreeFamiTF325759.

Enzyme and pathway databases

BRENDAi2.5.1.18. 2681.
ReactomeiR-HSA-156590. Glutathione conjugation.

Miscellaneous databases

EvolutionaryTraceiP0CG30.
GeneWikiiGSTT2.
GenomeRNAii653689.
PROiP0CG30.

Gene expression databases

BgeeiENSG00000133433.
ExpressionAtlasiP0CG30. baseline and differential.
GenevisibleiP0CG30. HS.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTT2_HUMAN
AccessioniPrimary (citable) accession number: P0CG30
Secondary accession number(s): O60665
, P30712, Q6IPV7, Q9HD76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 2, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.