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Protein

Glutathione S-transferase theta-2

Gene

GSTT2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a sulfatase activity.

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei40GlutathioneBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Enzyme and pathway databases

ReactomeiR-HSA-156590. Glutathione conjugation.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase theta-2 (EC:2.5.1.18)
Alternative name(s):
GST class-theta-2
Gene namesi
Name:GSTT2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:4642. GSTT2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi2953.
OpenTargetsiENSG00000277897.

Chemistry databases

ChEMBLiCHEMBL2142.

Polymorphism and mutation databases

DMDMi300680960.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001859392 – 244Glutathione S-transferase theta-2Add BLAST243

Proteomic databases

MaxQBiP0CG29.
PaxDbiP0CG29.
PeptideAtlasiP0CG29.
PRIDEiP0CG29.

PTM databases

iPTMnetiP0CG29.
PhosphoSitePlusiP0CG29.

Expressioni

Tissue specificityi

Expressed at low levels in liver. In lung, expressed at low levels in ciliated bronchiolar cells, alveolar macrophages and alveolar type II cells.1 Publication

Gene expression databases

BgeeiENSG00000099984.

Organism-specific databases

HPAiHPA000750.

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi9606.ENSP00000215780.

Structurei

Secondary structure

1244
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 7Combined sources5
Helixi12 – 23Combined sources12
Beta strandi28 – 32Combined sources5
Turni35 – 38Combined sources4
Helixi39 – 41Combined sources3
Helixi43 – 46Combined sources4
Beta strandi56 – 59Combined sources4
Beta strandi62 – 65Combined sources4
Helixi67 – 77Combined sources11
Helixi82 – 84Combined sources3
Helixi89 – 105Combined sources17
Turni106 – 111Combined sources6
Helixi112 – 117Combined sources6
Helixi119 – 122Combined sources4
Helixi129 – 148Combined sources20
Turni149 – 153Combined sources5
Beta strandi154 – 156Combined sources3
Beta strandi159 – 161Combined sources3
Helixi164 – 177Combined sources14
Turni178 – 180Combined sources3
Turni183 – 186Combined sources4
Helixi188 – 201Combined sources14
Helixi203 – 214Combined sources12
Helixi216 – 221Combined sources6
Helixi230 – 241Combined sources12

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MPFX-ray2.10A/B1-244[»]
ProteinModelPortaliP0CG29.
SMRiP0CG29.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 82GST N-terminalAdd BLAST81
Domaini88 – 224GST C-terminalAdd BLAST137

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni53 – 54Glutathione bindingBy similarity2
Regioni66 – 67Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Theta family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
HOGENOMiHOG000125747.
InParanoidiP0CG29.
KOiK00799.
OMAiGVPLWVQ.
OrthoDBiEOG091G0PCG.
PhylomeDBiP0CG29.
TreeFamiTF325759.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CG29-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLELFLDLV SQPSRAVYIF AKKNGIPLEL RTVDLVKGQH KSKEFLQINS
60 70 80 90 100
LGKLPTLKDG DFILTESSAI LIYLSCKYQT PDHWYPSDLQ ARARVHEYLG
110 120 130 140 150
WHADCIRGTF GIPLWVQVLG PLIGVQVPKE KVERNRTAMD QALQWLEDKF
160 170 180 190 200
LGDRPFLAGQ QVTLADLMAL EELMQPVALG YELFEGRPRL AAWRGRVEAF
210 220 230 240
LGAELCQEAH SIILSILEQA AKKTLPTPSP EAYQAMLLRI ARIP
Length:244
Mass (Da):27,506
Last modified:July 13, 2010 - v1
Checksum:iDBA15D045262FFC3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2G → V AA sequence (PubMed:1417752).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240786 Genomic DNA. Translation: AAG02373.1.
AP000351 Genomic DNA. No translation available.
PIRiA56847.
RefSeqiNP_000845.2. NM_000854.4.
UniGeneiHs.654462.
Hs.656498.

Genome annotation databases

EnsembliENST00000215780; ENSP00000215780; ENSG00000099984.
ENST00000618279; ENSP00000477540; ENSG00000277897.
GeneIDi2953.
KEGGihsa:2953.
UCSCiuc032qyg.2. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF240786 Genomic DNA. Translation: AAG02373.1.
AP000351 Genomic DNA. No translation available.
PIRiA56847.
RefSeqiNP_000845.2. NM_000854.4.
UniGeneiHs.654462.
Hs.656498.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MPFX-ray2.10A/B1-244[»]
ProteinModelPortaliP0CG29.
SMRiP0CG29.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000215780.

Chemistry databases

ChEMBLiCHEMBL2142.

PTM databases

iPTMnetiP0CG29.
PhosphoSitePlusiP0CG29.

Polymorphism and mutation databases

DMDMi300680960.

Proteomic databases

MaxQBiP0CG29.
PaxDbiP0CG29.
PeptideAtlasiP0CG29.
PRIDEiP0CG29.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000215780; ENSP00000215780; ENSG00000099984.
ENST00000618279; ENSP00000477540; ENSG00000277897.
GeneIDi2953.
KEGGihsa:2953.
UCSCiuc032qyg.2. human.

Organism-specific databases

CTDi2953.
DisGeNETi2953.
GeneCardsiGSTT2.
HGNCiHGNC:4642. GSTT2.
HPAiHPA000750.
MIMi600437. gene.
neXtProtiNX_P0CG29.
OpenTargetsiENSG00000277897.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0867. Eukaryota.
COG0625. LUCA.
HOGENOMiHOG000125747.
InParanoidiP0CG29.
KOiK00799.
OMAiGVPLWVQ.
OrthoDBiEOG091G0PCG.
PhylomeDBiP0CG29.
TreeFamiTF325759.

Enzyme and pathway databases

ReactomeiR-HSA-156590. Glutathione conjugation.

Miscellaneous databases

GenomeRNAii2953.
PROiP0CG29.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000099984.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF02798. GST_N. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGST2_HUMAN
AccessioniPrimary (citable) accession number: P0CG29
Secondary accession number(s): O60665
, P30712, Q6IPV7, Q9HD76
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 13, 2010
Last sequence update: July 13, 2010
Last modified: November 2, 2016
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.