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Protein

Zinc finger protein 883

Gene

ZNF883

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri13 – 3523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri41 – 6323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri69 – 9123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri97 – 11923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 14723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri153 – 17523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri181 – 20323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein 883
Gene namesi
Name:ZNF883
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:27271. ZNF883.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA165586440.

Polymorphism and mutation databases

BioMutaiZNF883.
DMDMi298351897.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 379379Zinc finger protein 883PRO_0000395113Add
BLAST

Proteomic databases

PRIDEiP0CG24.

PTM databases

PhosphoSiteiP0CG24.

Structurei

3D structure databases

ProteinModelPortaliP0CG24.
SMRiP0CG24. Positions 28-288, 291-371.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 13 C2H2-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri13 – 3523C2H2-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri41 – 6323C2H2-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri69 – 9123C2H2-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri97 – 11923C2H2-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri125 – 14723C2H2-type 5PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri153 – 17523C2H2-type 6PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri181 – 20323C2H2-type 7PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri209 – 23123C2H2-type 8PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri237 – 25923C2H2-type 9PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri265 – 28723C2H2-type 10PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri293 – 31523C2H2-type 11PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri321 – 34323C2H2-type 12PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri349 – 37123C2H2-type 13PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

InParanoidiP0CG24.
PhylomeDBiP0CG24.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CG24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESEKIYMTA NPYLCTECGK GYTCLASLTQ HQKTHIGEKP YECKICGKSF
60 70 80 90 100
TRNSNLVQHQ RIHTGEKPYE CNECGKAFSQ STNLIQHQRV HTGEKPYECN
110 120 130 140 150
ECEKTFSHRS SLRNHERIHT GEKPYPCNEC GKAFSHISAL TQHHRIHTGK
160 170 180 190 200
KPYECTECGK TFSRSTHLIE HQGIHSEEKS YQCKQCRKVF CHSTSLIRHQ
210 220 230 240 250
RTHTGEKPYE CNECGKAFSH TPAFIQHQRI HTGEKPYECN ACGKAFNRSA
260 270 280 290 300
HLTEHQRTHT GEKPYVCKEC GKTFSRSTHL TEHLKIHSCV KPYQCNECQK
310 320 330 340 350
LFCYRTSLIR HQRTHTGEKP YQCNECGKSF SLSSALTKHK RIHTRERPYQ
360 370
CTKCGDVFCH STSLIRHQKT HFRKETLAE
Length:379
Mass (Da):43,967
Last modified:June 15, 2010 - v1
Checksum:iAD5D4192C78E1FC5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162588 Genomic DNA. No translation available.
AK095843 mRNA. No translation available.
RefSeqiNP_001094808.1. NM_001101338.1.
UniGeneiHs.192877.

Genome annotation databases

GeneIDi169834.
KEGGihsa:169834.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL162588 Genomic DNA. No translation available.
AK095843 mRNA. No translation available.
RefSeqiNP_001094808.1. NM_001101338.1.
UniGeneiHs.192877.

3D structure databases

ProteinModelPortaliP0CG24.
SMRiP0CG24. Positions 28-288, 291-371.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP0CG24.

Polymorphism and mutation databases

BioMutaiZNF883.
DMDMi298351897.

Proteomic databases

PRIDEiP0CG24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi169834.
KEGGihsa:169834.

Organism-specific databases

CTDi169834.
GeneCardsiZNF883.
HGNCiHGNC:27271. ZNF883.
neXtProtiNX_P0CG24.
PharmGKBiPA165586440.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiP0CG24.
PhylomeDBiP0CG24.

Miscellaneous databases

GenomeRNAii169834.
NextBioi88839.
PROiP0CG24.

Family and domain databases

Gene3Di3.30.160.60. 13 hits.
InterProiIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR013087. Znf_C2H2/integrase_DNA-bd.
[Graphical view]
PfamiPF00096. zf-C2H2. 6 hits.
PF13912. zf-C2H2_6. 2 hits.
[Graphical view]
SMARTiSM00355. ZnF_C2H2. 13 hits.
[Graphical view]
PROSITEiPS00028. ZINC_FINGER_C2H2_1. 13 hits.
PS50157. ZINC_FINGER_C2H2_2. 13 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-348.
    Tissue: Chondrocyte.

Entry informationi

Entry nameiZN883_HUMAN
AccessioniPrimary (citable) accession number: P0CG24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: March 16, 2016
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.