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Protein

Putative dehydrogenase/reductase SDR family member 4-like 1

Gene

DHRS4L1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Putative oxidoreductase.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei172 – 1721SubstrateBy similarity
Active sitei185 – 1851Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 6025NADPBy similarityAdd
BLAST

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
Putative dehydrogenase/reductase SDR family member 4-like 1 (EC:1.1.-.-)
Alternative name(s):
Short chain dehydrogenase/reductase family 25C member 4
Gene namesi
Name:DHRS4L1
Synonyms:SDR25C4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:19732. DHRS4L1.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134878665.

Polymorphism and mutation databases

DMDMi298351658.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 281281Putative dehydrogenase/reductase SDR family member 4-like 1PRO_0000395063Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921N6-acetyllysine; alternateBy similarity
Modified residuei92 – 921N6-succinyllysine; alternateBy similarity
Modified residuei105 – 1051N6-acetyllysineBy similarity
Modified residuei219 – 2191N6-acetyllysine; alternateBy similarity
Modified residuei219 – 2191N6-succinyllysine; alternateBy similarity
Modified residuei223 – 2231PhosphoserineBy similarity
Modified residuei230 – 2301N6-succinyllysineBy similarity
Modified residuei237 – 2371N6-succinyllysineBy similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP0CG22.
PRIDEiP0CG22.

PTM databases

PhosphoSiteiP0CG22.

Expressioni

Organism-specific databases

HPAiHPA023972.

Structurei

3D structure databases

ProteinModelPortaliP0CG22.
SMRiP0CG22. Positions 29-281.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi279 – 2813Microbody targeting signalBy similarity

Sequence similaritiesi

Phylogenomic databases

InParanoidiP0CG22.
PhylomeDBiP0CG22.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029511. DHRS4-like.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF528. PTHR24322:SF528. 2 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CG22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHKARLRGHC ARAGKSVRLA SSGMTRRDPL TNKVALVTAS TDWIGFAVAQ
60 70 80 90 100
RLAQDGAHVV VSRRKQQNVD QAVATLQGEG LSMTGTVCHV GKMKDWERLV
110 120 130 140 150
ATAMKLHGVI DILSLSITNS KRGLFWFTLL QTAEEAWDRN LDINGKALAL
160 170 180 190 200
MIKAVVPEME KRGGGSVGFL ASVAAFRPLP GFSPYNVSKT ALLGLNKTLA
210 220 230 240 250
IELAPRNIRV NCLAPGLIKT SFSRMLWMDK EKEESMKETL RIRRLGEPED
260 270 280
SLGIVSFLCS EDASYLTGET VMVGGGTPSR L
Length:281
Mass (Da):30,608
Last modified:June 15, 2010 - v1
Checksum:iEC8FFF8B6145FA18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136295 Genomic DNA. No translation available.
UniGeneiHs.647569.
Hs.743442.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL136295 Genomic DNA. No translation available.
UniGeneiHs.647569.
Hs.743442.

3D structure databases

ProteinModelPortaliP0CG22.
SMRiP0CG22. Positions 29-281.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiP0CG22.

Polymorphism and mutation databases

DMDMi298351658.

Proteomic databases

EPDiP0CG22.
PRIDEiP0CG22.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiDHRS4L1.
HGNCiHGNC:19732. DHRS4L1.
HPAiHPA023972.
MIMi615195. gene.
neXtProtiNX_P0CG22.
PharmGKBiPA134878665.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiP0CG22.
PhylomeDBiP0CG22.

Miscellaneous databases

NextBioi127824.
SOURCEiSearch...

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029511. DHRS4-like.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 2 hits.
PTHR24322:SF528. PTHR24322:SF528. 2 hits.
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence and analysis of human chromosome 14."
    Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
    , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
    Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiDR4L1_HUMAN
AccessioniPrimary (citable) accession number: P0CG22
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: May 11, 2016
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Product of a dubious CDS prediction.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.