ID PRR35_HUMAN Reviewed; 571 AA. AC P0CG20; B8ZZ27; Q8N233; Q96AX3; Q96S23; DT 15-JUN-2010, integrated into UniProtKB/Swiss-Prot. DT 15-JUN-2010, sequence version 1. DT 24-JAN-2024, entry version 79. DE RecName: Full=Proline-rich protein 35; DE AltName: Full=Uncharacterized protein RJD1; GN Name=PRR35; Synonyms=C16orf11; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=11157797; DOI=10.1093/hmg/10.4.339; RA Daniels R.J., Peden J.F., Lloyd C., Horsley S.W., Clark K., Tufarelli C., RA Kearney L., Buckle V.J., Doggett N.A., Flint J., Higgs D.R.; RT "Sequence, structure and pathology of the fully annotated terminal 2 Mb of RT the short arm of human chromosome 16."; RL Hum. Mol. Genet. 10:339-352(2001). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=15616553; DOI=10.1038/nature03187; RA Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., RA Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., RA Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J., Buckingham J.M., RA Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., RA Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., RA Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., RA Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., RA Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., RA Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., RA Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., RA Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., RA Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., RA Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., RA Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., RA Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., RA Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., RA Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., RA Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., RA Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., RA DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., RA Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., RA Myers R.M., Rubin E.M., Pennacchio L.A.; RT "The sequence and analysis of duplication-rich human chromosome 16."; RL Nature 432:988-994(2004). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., RA Hunkapiller M.W., Myers E.W., Venter J.C.; RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Eye; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- INTERACTION: CC P0CG20; Q8NFV4-4: ABHD11; NbExp=3; IntAct=EBI-11986293, EBI-12318443; CC P0CG20; Q5BKX5-3: ACTMAP; NbExp=3; IntAct=EBI-11986293, EBI-11976299; CC P0CG20; Q03154: ACY1; NbExp=3; IntAct=EBI-11986293, EBI-742064; CC P0CG20; Q8NEU8: APPL2; NbExp=3; IntAct=EBI-11986293, EBI-741261; CC P0CG20; Q96C12: ARMC5; NbExp=3; IntAct=EBI-11986293, EBI-6425121; CC P0CG20; Q8WXK1: ASB15; NbExp=3; IntAct=EBI-11986293, EBI-12809012; CC P0CG20; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-11986293, EBI-742722; CC P0CG20; Q96CA5: BIRC7; NbExp=3; IntAct=EBI-11986293, EBI-517623; CC P0CG20; Q9NP55: BPIFA1; NbExp=3; IntAct=EBI-11986293, EBI-953896; CC P0CG20; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-11986293, EBI-3866279; CC P0CG20; Q9H5F2: CFAP68; NbExp=3; IntAct=EBI-11986293, EBI-718615; CC P0CG20; Q9NZN8: CNOT2; NbExp=3; IntAct=EBI-11986293, EBI-743033; CC P0CG20; O43186: CRX; NbExp=3; IntAct=EBI-11986293, EBI-748171; CC P0CG20; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-11986293, EBI-3867333; CC P0CG20; Q8IYI6: EXOC8; NbExp=3; IntAct=EBI-11986293, EBI-742102; CC P0CG20; A1KXE4-2: FAM168B; NbExp=3; IntAct=EBI-11986293, EBI-12193763; CC P0CG20; Q13643: FHL3; NbExp=3; IntAct=EBI-11986293, EBI-741101; CC P0CG20; O94915-2: FRYL; NbExp=3; IntAct=EBI-11986293, EBI-12023420; CC P0CG20; O75420: GIGYF1; NbExp=3; IntAct=EBI-11986293, EBI-947774; CC P0CG20; O75791: GRAP2; NbExp=3; IntAct=EBI-11986293, EBI-740418; CC P0CG20; Q9NSC5: HOMER3; NbExp=3; IntAct=EBI-11986293, EBI-748420; CC P0CG20; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-11986293, EBI-10961706; CC P0CG20; P84074: HPCA; NbExp=3; IntAct=EBI-11986293, EBI-12197079; CC P0CG20; Q16082: HSPB2; NbExp=3; IntAct=EBI-11986293, EBI-739395; CC P0CG20; Q1MX18: INSC; NbExp=3; IntAct=EBI-11986293, EBI-12081118; CC P0CG20; Q5TA45: INTS11; NbExp=3; IntAct=EBI-11986293, EBI-748258; CC P0CG20; P14923: JUP; NbExp=3; IntAct=EBI-11986293, EBI-702484; CC P0CG20; Q53HC5: KLHL26; NbExp=3; IntAct=EBI-11986293, EBI-724915; CC P0CG20; Q15323: KRT31; NbExp=3; IntAct=EBI-11986293, EBI-948001; CC P0CG20; O76011: KRT34; NbExp=5; IntAct=EBI-11986293, EBI-1047093; CC P0CG20; Q92764: KRT35; NbExp=3; IntAct=EBI-11986293, EBI-1058674; CC P0CG20; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11986293, EBI-10172290; CC P0CG20; P59990: KRTAP12-1; NbExp=3; IntAct=EBI-11986293, EBI-10210845; CC P0CG20; Q6PEX3: KRTAP26-1; NbExp=3; IntAct=EBI-11986293, EBI-3957672; CC P0CG20; Q3LI64: KRTAP6-1; NbExp=3; IntAct=EBI-11986293, EBI-12111050; CC P0CG20; Q3LI66: KRTAP6-2; NbExp=5; IntAct=EBI-11986293, EBI-11962084; CC P0CG20; Q8IUC2: KRTAP8-1; NbExp=3; IntAct=EBI-11986293, EBI-10261141; CC P0CG20; Q14847-2: LASP1; NbExp=3; IntAct=EBI-11986293, EBI-9088686; CC P0CG20; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-11986293, EBI-2341787; CC P0CG20; Q9BRK4: LZTS2; NbExp=3; IntAct=EBI-11986293, EBI-741037; CC P0CG20; Q9Y5V3: MAGED1; NbExp=3; IntAct=EBI-11986293, EBI-716006; CC P0CG20; P59942: MCCD1; NbExp=3; IntAct=EBI-11986293, EBI-11987923; CC P0CG20; Q13064: MKRN3; NbExp=3; IntAct=EBI-11986293, EBI-2340269; CC P0CG20; Q4VC12: MSS51; NbExp=3; IntAct=EBI-11986293, EBI-11599933; CC P0CG20; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-11986293, EBI-11522433; CC P0CG20; O15049: N4BP3; NbExp=3; IntAct=EBI-11986293, EBI-2512055; CC P0CG20; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-11986293, EBI-22310682; CC P0CG20; O43482: OIP5; NbExp=3; IntAct=EBI-11986293, EBI-536879; CC P0CG20; Q8TDS5: OXER1; NbExp=3; IntAct=EBI-11986293, EBI-12813389; CC P0CG20; Q99471: PFDN5; NbExp=3; IntAct=EBI-11986293, EBI-357275; CC P0CG20; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-11986293, EBI-2876622; CC P0CG20; Q9Y3C6: PPIL1; NbExp=3; IntAct=EBI-11986293, EBI-2557649; CC P0CG20; Q96KQ4: PPP1R13B; NbExp=3; IntAct=EBI-11986293, EBI-1105153; CC P0CG20; P86480: PRR20D; NbExp=3; IntAct=EBI-11986293, EBI-12754095; CC P0CG20; O43586: PSTPIP1; NbExp=3; IntAct=EBI-11986293, EBI-1050964; CC P0CG20; Q93062-3: RBPMS; NbExp=3; IntAct=EBI-11986293, EBI-740343; CC P0CG20; Q9BVN2: RUSC1; NbExp=3; IntAct=EBI-11986293, EBI-6257312; CC P0CG20; Q53HV7-2: SMUG1; NbExp=3; IntAct=EBI-11986293, EBI-12275818; CC P0CG20; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-11986293, EBI-11959123; CC P0CG20; O60806: TBX19; NbExp=3; IntAct=EBI-11986293, EBI-12096770; CC P0CG20; Q08117-2: TLE5; NbExp=5; IntAct=EBI-11986293, EBI-11741437; CC P0CG20; P14373: TRIM27; NbExp=3; IntAct=EBI-11986293, EBI-719493; CC P0CG20; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-11986293, EBI-2130429; CC P0CG20; Q86UV6-2: TRIM74; NbExp=3; IntAct=EBI-11986293, EBI-10259086; CC P0CG20; Q6DKK2: TTC19; NbExp=3; IntAct=EBI-11986293, EBI-948354; CC P0CG20; Q14166: TTLL12; NbExp=3; IntAct=EBI-11986293, EBI-923010; CC P0CG20; Q8TF42: UBASH3B; NbExp=3; IntAct=EBI-11986293, EBI-1380492; CC P0CG20; Q5T124-6: UBXN11; NbExp=3; IntAct=EBI-11986293, EBI-11524408; CC P0CG20; Q70EL1-9: USP54; NbExp=3; IntAct=EBI-11986293, EBI-11975223; CC P0CG20; Q9H0C1: ZMYND12; NbExp=3; IntAct=EBI-11986293, EBI-12030590; CC P0CG20; Q8N720: ZNF655; NbExp=3; IntAct=EBI-11986293, EBI-625509; CC -!- SEQUENCE CAUTION: CC Sequence=AAK61234.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AE006464; AAK61234.1; ALT_SEQ; Genomic_DNA. DR EMBL; Z97986; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; CH471112; EAW85802.1; -; Genomic_DNA. DR EMBL; BC016613; AAH16613.1; -; mRNA. DR CCDS; CCDS45365.1; -. DR RefSeq; NP_660313.1; NM_145270.2. DR RefSeq; XP_016878448.1; XM_017022959.1. DR RefSeq; XP_016878449.1; XM_017022960.1. DR AlphaFoldDB; P0CG20; -. DR SMR; P0CG20; -. DR BioGRID; 126978; 82. DR IntAct; P0CG20; 71. DR STRING; 9606.ENSP00000386499; -. DR iPTMnet; P0CG20; -. DR PhosphoSitePlus; P0CG20; -. DR BioMuta; PRR35; -. DR DMDM; 298351619; -. DR jPOST; P0CG20; -. DR MassIVE; P0CG20; -. DR PaxDb; 9606-ENSP00000386499; -. DR PeptideAtlas; P0CG20; -. DR Antibodypedia; 68294; 7 antibodies from 7 providers. DR DNASU; 146325; -. DR Ensembl; ENST00000409413.4; ENSP00000386499.3; ENSG00000161992.6. DR GeneID; 146325; -. DR KEGG; hsa:146325; -. DR MANE-Select; ENST00000409413.4; ENSP00000386499.3; NM_145270.3; NP_660313.1. DR UCSC; uc002chk.4; human. DR AGR; HGNC:14139; -. DR CTD; 146325; -. DR DisGeNET; 146325; -. DR GeneCards; PRR35; -. DR HGNC; HGNC:14139; PRR35. DR HPA; ENSG00000161992; Tissue enriched (brain). DR neXtProt; NX_P0CG20; -. DR OpenTargets; ENSG00000161992; -. DR PharmGKB; PA25524; -. DR VEuPathDB; HostDB:ENSG00000161992; -. DR eggNOG; ENOG502QRT7; Eukaryota. DR GeneTree; ENSGT00530000063870; -. DR HOGENOM; CLU_022992_0_0_1; -. DR InParanoid; P0CG20; -. DR OMA; WKPGMGG; -. DR OrthoDB; 4137426at2759; -. DR PhylomeDB; P0CG20; -. DR TreeFam; TF331381; -. DR PathwayCommons; P0CG20; -. DR SignaLink; P0CG20; -. DR BioGRID-ORCS; 146325; 15 hits in 1127 CRISPR screens. DR GenomeRNAi; 146325; -. DR Pharos; P0CG20; Tdark. DR PRO; PR:P0CG20; -. DR Proteomes; UP000005640; Chromosome 16. DR RNAct; P0CG20; Protein. DR Bgee; ENSG00000161992; Expressed in cerebellar hemisphere and 34 other cell types or tissues. DR InterPro; IPR039363; ZNF750. DR InterPro; IPR039064; ZNF750_Znf. DR PANTHER; PTHR14678:SF2; PROLINE-RICH PROTEIN 35; 1. DR PANTHER; PTHR14678; UNCHARACTERIZED; 1. DR Pfam; PF15269; zf-C2H2_7; 1. DR Genevisible; P0CG20; HS. PE 1: Evidence at protein level; KW Reference proteome. FT CHAIN 1..571 FT /note="Proline-rich protein 35" FT /id="PRO_0000326184" FT REGION 1..27 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 79..188 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 286..402 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 476..571 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 320..342 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 353..367 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 378..397 FT /note="Pro residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 547..562 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 571 AA; 59354 MW; 7F15F84F05FF460E CRC64; MSREAGSCRV GTGARARSRK PKKPHYIPRP WGKPYNYKCF QCPFTCLEKS HLYNHMKYSL CKDSLSLLLD SPDWACRRGS TTPRPHAPTP DRPGESDPGR QPQGARPTGA APAPDLVVAD IHSLHCGGGP KSRAKGSPGP PPPVARATRK GPGPSGLLPE SWKPGMGGDP RGVGAGDMAS AGPEGSVPCY PPPAPGEFPE AHSLHLSLLG VNYPLSPGLF SYLGPSLAAA AHVPFLASAS PLLPPATAFP AVQPPQRPTP APRLYYPLLL EHTLGLPAGK AALAKAPVSP RSPSGTPAPG LLKVPVPGLG PWPRVTPRDP GQEGELERAA QSDPRRRLSL GSRLELPKAS PSLTRFCSRS SLPTGSSVML WPEDGDPGGP ETPGPEGPLP LQPRGPVPGS PEHVGEDLTR ALGDYARVEQ RLGQLGPAGG LAPRPLREQL GKIRLELLTI HQALEQAVRP PDAPLDLSVK RAPAKGPQAL GEAWGRPELG PVLTGGTPEP PGMLGPAAPQ PFSGHTTKCE ADSSVPPPGL PLAAPDDPVI PGSGWGTCVA TRSSQTPEAV CGLQSPQGAE V //