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Protein

Chromosome transmission fidelity protein 8 homolog isoform 2

Gene

Chtf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Potential tumor suppressor.By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome transmission fidelity protein 8 homolog isoform 2
Gene namesi
Name:Chtf8
Synonyms:Derpc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:2443370. Chtf8.

Subcellular locationi

  1. Nucleus By similarity

GO - Cellular componenti

  1. extracellular vesicular exosome Source: MGI
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 533533Chromosome transmission fidelity protein 8 homolog isoform 2PRO_0000326397Add
BLAST

Proteomic databases

PRIDEiP0CG14.

PTM databases

PhosphoSiteiP0CG14.

Expressioni

Gene expression databases

BgeeiP0CG14.
ExpressionAtlasiP0CG14. baseline and differential.

Interactioni

Protein-protein interaction databases

BioGridi229585. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP0CG14.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 533530Pro-richAdd
BLAST
Compositional biasi95 – 374280Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the DERPC family.Curated

Phylogenomic databases

GeneTreeiENSGT00400000025006.
HOGENOMiHOG000112197.
InParanoidiP0CG14.
KOiK11270.
OMAiKEPRIFP.
OrthoDBiEOG71G9X9.
PhylomeDBiP0CG14.
TreeFamiTF338736.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P0CG14-1) [UniParc]FASTAAdd to basket

Also known as: DERPC

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEPRIFPRE RPTPWTRAPL PPRGRLDGGP VMNAGHPMGV NSDPFLMAAG
60 70 80 90 100
SLGGNLAPFP RNAAPFQNPS GSLASNPAHF AAGARDPGMT SFPRGMNPTG
110 120 130 140 150
TGAVSFPRPG GLLGPGPGPG LNPRTGALPG PGPMSNPRLG GLPGPGPMAN
160 170 180 190 200
PRAGGLLGAS PDPRSGGPMV PGCGPNMRAG VLSSGTGPPN PRPVGLGPGP
210 220 230 240 250
SPNLRSSFLG TNPAPRSGMF PGPGLGPNPR ACGLGPGLGP NPRAGGLGPG
260 270 280 290 300
PNLDNRAGGL LGTGSGLNLR MAGPQGLDLA PILRAAGLLG TNSVSFSQAS
310 320 330 340 350
GNMGTNPPTM TRVPGPIGPN TGPSSRGLGL PGPNPSPMSR APGPMGPNSA
360 370 380 390 400
HFSRPGGPMG VNAGVFPRGT GSGGLNPNAF SQSSGTLASN PGTFQRSAGL
410 420 430 440 450
QGSNQAVFPR ASGPLGPNPA NFPRATGLQG PSPAAFPRSA GPLGPGQVAF
460 470 480 490 500
PRSAAGHLGS SPAGPVGINP APFARPTGTL GLNPASFPRM NGPVGKTLVP
510 520 530
FPRVGSLPGS NPAAFPRPGG PMAAMYPNGM LPP
Length:533
Mass (Da):52,244
Last modified:June 15, 2010 - v1
Checksum:i0399DF3ABE73C5F6
GO
Isoform 1 (identifier: P0CG15-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry P0CG15.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:121
Mass (Da):13,228
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK165993 mRNA. Translation: BAE38506.1.
RefSeqiNP_663387.3. NM_145412.3.
UniGeneiMm.490308.

Genome annotation databases

EnsembliENSMUST00000169312; ENSMUSP00000129823; ENSMUSG00000046691. [P0CG14-1]
GeneIDi214987.
KEGGimmu:214987.
UCSCiuc009ngo.1. mouse. [P0CG14-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK165993 mRNA. Translation: BAE38506.1.
RefSeqiNP_663387.3. NM_145412.3.
UniGeneiMm.490308.

3D structure databases

ProteinModelPortaliP0CG14.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229585. 1 interaction.

PTM databases

PhosphoSiteiP0CG14.

Proteomic databases

PRIDEiP0CG14.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169312; ENSMUSP00000129823; ENSMUSG00000046691. [P0CG14-1]
GeneIDi214987.
KEGGimmu:214987.
UCSCiuc009ngo.1. mouse. [P0CG14-1]

Organism-specific databases

CTDi54921.
MGIiMGI:2443370. Chtf8.

Phylogenomic databases

GeneTreeiENSGT00400000025006.
HOGENOMiHOG000112197.
InParanoidiP0CG14.
KOiK11270.
OMAiKEPRIFP.
OrthoDBiEOG71G9X9.
PhylomeDBiP0CG14.
TreeFamiTF338736.

Miscellaneous databases

NextBioi374562.
SOURCEiSearch...

Gene expression databases

BgeeiP0CG14.
ExpressionAtlasiP0CG14. baseline and differential.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.

Entry informationi

Entry nameiCTF8A_MOUSE
AccessioniPrimary (citable) accession number: P0CG14
Secondary accession number(s): P0C6T0, Q8BHM2, Q8R5A5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 29, 2015
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.