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Protein

Chromosome transmission fidelity protein 8 homolog isoform 2

Gene

Chtf8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Potential tumor suppressor.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome transmission fidelity protein 8 homolog isoform 2
Gene namesi
Name:Chtf8
Synonyms:Derpc
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:2443370 Chtf8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003263971 – 533Chromosome transmission fidelity protein 8 homolog isoform 2Add BLAST533

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei160PhosphoserineBy similarity1
Modified residuei368Asymmetric dimethylarginineCombined sources1
Modified residuei396Omega-N-methylarginineCombined sources1
Modified residuei432PhosphoserineBy similarity1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PeptideAtlasiP0CG14
PRIDEiP0CG14

PTM databases

iPTMnetiP0CG14
PhosphoSitePlusiP0CG14

Expressioni

Gene expression databases

BgeeiENSMUSG00000046691
ExpressionAtlasiP0CG14 baseline and differential
GenevisibleiP0CG14 MM

Interactioni

Protein-protein interaction databases

BioGridi229585, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliP0CG14
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi4 – 533Pro-richAdd BLAST530
Compositional biasi95 – 374Gly-richAdd BLAST280

Sequence similaritiesi

Belongs to the DERPC family.Curated

Phylogenomic databases

GeneTreeiENSGT00400000025006
HOGENOMiHOG000112197
InParanoidiP0CG14
KOiK11270
OMAiNLAPFPR
OrthoDBiEOG091G076T
PhylomeDBiP0CG14
TreeFamiTF338736

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P0CG14-1) [UniParc]FASTAAdd to basket
Also known as: DERPC

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEPRIFPRE RPTPWTRAPL PPRGRLDGGP VMNAGHPMGV NSDPFLMAAG
60 70 80 90 100
SLGGNLAPFP RNAAPFQNPS GSLASNPAHF AAGARDPGMT SFPRGMNPTG
110 120 130 140 150
TGAVSFPRPG GLLGPGPGPG LNPRTGALPG PGPMSNPRLG GLPGPGPMAN
160 170 180 190 200
PRAGGLLGAS PDPRSGGPMV PGCGPNMRAG VLSSGTGPPN PRPVGLGPGP
210 220 230 240 250
SPNLRSSFLG TNPAPRSGMF PGPGLGPNPR ACGLGPGLGP NPRAGGLGPG
260 270 280 290 300
PNLDNRAGGL LGTGSGLNLR MAGPQGLDLA PILRAAGLLG TNSVSFSQAS
310 320 330 340 350
GNMGTNPPTM TRVPGPIGPN TGPSSRGLGL PGPNPSPMSR APGPMGPNSA
360 370 380 390 400
HFSRPGGPMG VNAGVFPRGT GSGGLNPNAF SQSSGTLASN PGTFQRSAGL
410 420 430 440 450
QGSNQAVFPR ASGPLGPNPA NFPRATGLQG PSPAAFPRSA GPLGPGQVAF
460 470 480 490 500
PRSAAGHLGS SPAGPVGINP APFARPTGTL GLNPASFPRM NGPVGKTLVP
510 520 530
FPRVGSLPGS NPAAFPRPGG PMAAMYPNGM LPP
Length:533
Mass (Da):52,244
Last modified:June 15, 2010 - v1
Checksum:i0399DF3ABE73C5F6
GO
Isoform 1 (identifier: P0CG15-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CG15.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:121
Mass (Da):13,228
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK165993 mRNA Translation: BAE38506.1
RefSeqiNP_663387.3, NM_145412.3
XP_017168143.1, XM_017312654.1 [P0CG14-1]
XP_017168144.1, XM_017312655.1 [P0CG14-1]
XP_017168145.1, XM_017312656.1 [P0CG14-1]
UniGeneiMm.490308

Genome annotation databases

EnsembliENSMUST00000169312; ENSMUSP00000129823; ENSMUSG00000046691 [P0CG14-1]
GeneIDi214987
KEGGimmu:214987
UCSCiuc009ngq.1 mouse [P0CG14-1]

Keywords - Coding sequence diversityi

Alternative splicing

Entry informationi

Entry nameiCTF8A_MOUSE
AccessioniPrimary (citable) accession number: P0CG14
Secondary accession number(s): P0C6T0, Q8BHM2, Q8R5A5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 25, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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