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P0CG14 (CTF8A_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Chromosome transmission fidelity protein 8 homolog isoform 2
Gene names
Name:Chtf8
Synonyms:Derpc
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length533 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Potential tumor suppressor By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the DERPC family.

Ontologies

Keywords
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 2 (identifier: P0CG14-1)

Also known as: DERPC;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 1 (identifier: P0CG15-1)

The sequence of this isoform can be found in the external entry P0CG15.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 533533Chromosome transmission fidelity protein 8 homolog isoform 2
PRO_0000326397

Regions

Compositional bias4 – 533530Pro-rich
Compositional bias95 – 374280Gly-rich

Sequences

Sequence LengthMass (Da)Tools
Isoform 2 (DERPC) [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 0399DF3ABE73C5F6

FASTA53352,244
        10         20         30         40         50         60 
MKEPRIFPRE RPTPWTRAPL PPRGRLDGGP VMNAGHPMGV NSDPFLMAAG SLGGNLAPFP 

        70         80         90        100        110        120 
RNAAPFQNPS GSLASNPAHF AAGARDPGMT SFPRGMNPTG TGAVSFPRPG GLLGPGPGPG 

       130        140        150        160        170        180 
LNPRTGALPG PGPMSNPRLG GLPGPGPMAN PRAGGLLGAS PDPRSGGPMV PGCGPNMRAG 

       190        200        210        220        230        240 
VLSSGTGPPN PRPVGLGPGP SPNLRSSFLG TNPAPRSGMF PGPGLGPNPR ACGLGPGLGP 

       250        260        270        280        290        300 
NPRAGGLGPG PNLDNRAGGL LGTGSGLNLR MAGPQGLDLA PILRAAGLLG TNSVSFSQAS 

       310        320        330        340        350        360 
GNMGTNPPTM TRVPGPIGPN TGPSSRGLGL PGPNPSPMSR APGPMGPNSA HFSRPGGPMG 

       370        380        390        400        410        420 
VNAGVFPRGT GSGGLNPNAF SQSSGTLASN PGTFQRSAGL QGSNQAVFPR ASGPLGPNPA 

       430        440        450        460        470        480 
NFPRATGLQG PSPAAFPRSA GPLGPGQVAF PRSAAGHLGS SPAGPVGINP APFARPTGTL 

       490        500        510        520        530 
GLNPASFPRM NGPVGKTLVP FPRVGSLPGS NPAAFPRPGG PMAAMYPNGM LPP 

« Hide

Isoform 1 [UniParc].

See P0CG15.

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK165993 mRNA. Translation: BAE38506.1.
RefSeqNP_663387.3. NM_145412.3.
UniGeneMm.490308.

3D structure databases

ProteinModelPortalP0CG14.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid229585. 1 interaction.

PTM databases

PhosphoSiteP0CG14.

Proteomic databases

PRIDEP0CG14.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000169312; ENSMUSP00000129823; ENSMUSG00000046691. [P0CG14-1]
GeneID214987.
KEGGmmu:214987.
UCSCuc009ngo.1. mouse. [P0CG14-1]

Organism-specific databases

CTD54921.
MGIMGI:2443370. Chtf8.

Phylogenomic databases

GeneTreeENSGT00400000025006.
HOGENOMHOG000112197.
KOK11270.
OMAKEPRIFP.
OrthoDBEOG71G9X9.
PhylomeDBP0CG14.
TreeFamTF338736.

Gene expression databases

ArrayExpressP0CG14.
BgeeP0CG14.

Family and domain databases

ProtoNetSearch...

Other

NextBio374562.
PROP0CG14.
SOURCESearch...

Entry information

Entry nameCTF8A_MOUSE
AccessionPrimary (citable) accession number: P0CG14
Secondary accession number(s): P0C6T0, Q8BHM2, Q8R5A5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot