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Protein

Chromosome transmission fidelity protein 8 homolog isoform 2

Gene

CHTF8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.1 Publication

Names & Taxonomyi

Protein namesi
Recommended name:
Chromosome transmission fidelity protein 8 homolog isoform 2
Alternative name(s):
Decreased expression in renal and prostate cancer protein
Gene namesi
Name:CHTF8
Synonyms:DERPC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:24353. CHTF8.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi298351628.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 524524Chromosome transmission fidelity protein 8 homolog isoform 2PRO_0000326396Add
BLAST

Proteomic databases

EPDiP0CG12.
PaxDbiP0CG12.
PRIDEiP0CG12.

PTM databases

iPTMnetiP0CG12.
PhosphoSiteiP0CG12.

Expressioni

Tissue specificityi

Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules.2 Publications

Gene expression databases

BgeeiP0CG12.
ExpressionAtlasiP0CG12. baseline and differential.
GenevisibleiP0CG12. HS.

Organism-specific databases

HPAiHPA051872.

Interactioni

Protein-protein interaction databases

IntActiP0CG12. 3 interactions.

Structurei

3D structure databases

ProteinModelPortaliP0CG12.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi4 – 524521Pro-richAdd
BLAST
Compositional biasi101 – 328228Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the DERPC family.Curated

Phylogenomic databases

eggNOGiENOG410IVFI. Eukaryota.
ENOG410ZRNR. LUCA.
GeneTreeiENSGT00400000025006.
HOGENOMiHOG000243059.
InParanoidiP0CG12.
OMAiNLRMAGP.
OrthoDBiEOG71G9X9.
PhylomeDBiP0CG12.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: P0CG12-1) [UniParc]FASTAAdd to basket

Also known as: DERPC

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKEPRIFPRE RPTPWTRAPL PPRGRLDGSL GPQGGPVLNT GHPLGVNSDP
60 70 80 90 100
FLMAAGSLGG NLTPFPRNPS PFPASSGSLA SNPAPFPAGA RDPSMASFPR
110 120 130 140 150
GMNPTGTGAV SFPRPGGLLG PGPGPGPTLN PRTGALPGPG PLSNPRLGGL
160 170 180 190 200
PGPGPMSNPR AGGLLGAGPD PRGGGPMGPG SGPNLRAGVL LTSGNGPPNP
210 220 230 240 250
RPVGLGPGPN PNLRSGFLGT NPAPRSGVFP GPGLGPNPRP SGLGPGPNLD
260 270 280 290 300
ARAGGLLGTG SGLNLRMAGP QGLDLAPILR AAGLLGANSA SFSQASGNMG
310 320 330 340 350
TSPSSMARVP GPMGPNSGPS SRGIGLPGPN PSPMSRAPGP IGPNSAHFSR
360 370 380 390 400
PVGPMGVNAN PFPRGAGSSA FSQSSGTLAS NPATFQRSAG LQGSNPTIFP
410 420 430 440 450
RASGPLGPNP ANFPRATGLQ GPSPTTFPRS TGPLGPGQVT FPRPAAGHLG
460 470 480 490 500
PSPAGPVGIN PAPFTRPTGT LGLNPASFPR MNGPAGKSFV PFPRVGSLPG
510 520
TNPAAFPRPG GPMAAMYPNG MLPP
Length:524
Mass (Da):51,391
Last modified:June 15, 2010 - v1
Checksum:iC917FEEC7BC3702E
GO
Isoform 1 (identifier: P0CG13-1) [UniParc]FASTAAdd to basket

The sequence of this isoform can be found in the external entry P0CG13.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Length:121
Mass (Da):13,314
GO

Sequence cautioni

The sequence CAD38758.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833902 mRNA. Translation: CAD38758.1. Different initiation.
AC009027 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83250.1.
RefSeqiXP_011521469.1. XM_011523167.1. [P0CG12-1]
XP_011521470.1. XM_011523168.1. [P0CG12-1]
UniGeneiHs.85962.

Genome annotation databases

EnsembliENST00000306585; ENSP00000305687; ENSG00000168802. [P0CG12-1]
GeneIDi54921.
UCSCiuc059wiz.1. human. [P0CG12-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833902 mRNA. Translation: CAD38758.1. Different initiation.
AC009027 Genomic DNA. No translation available.
CH471092 Genomic DNA. Translation: EAW83250.1.
RefSeqiXP_011521469.1. XM_011523167.1. [P0CG12-1]
XP_011521470.1. XM_011523168.1. [P0CG12-1]
UniGeneiHs.85962.

3D structure databases

ProteinModelPortaliP0CG12.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0CG12. 3 interactions.

PTM databases

iPTMnetiP0CG12.
PhosphoSiteiP0CG12.

Polymorphism and mutation databases

DMDMi298351628.

Proteomic databases

EPDiP0CG12.
PaxDbiP0CG12.
PRIDEiP0CG12.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306585; ENSP00000305687; ENSG00000168802. [P0CG12-1]
GeneIDi54921.
UCSCiuc059wiz.1. human. [P0CG12-1]

Organism-specific databases

CTDi54921.
GeneCardsiCHTF8.
H-InvDBHIX0013181.
HGNCiHGNC:24353. CHTF8.
HPAiHPA051872.
MIMi613202. gene.
neXtProtiNX_P0CG12.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IVFI. Eukaryota.
ENOG410ZRNR. LUCA.
GeneTreeiENSGT00400000025006.
HOGENOMiHOG000243059.
InParanoidiP0CG12.
OMAiNLRMAGP.
OrthoDBiEOG71G9X9.
PhylomeDBiP0CG12.

Miscellaneous databases

ChiTaRSiCHTF8. human.
GenomeRNAii54921.
SOURCEiSearch...

Gene expression databases

BgeeiP0CG12.
ExpressionAtlasiP0CG12. baseline and differential.
GenevisibleiP0CG12. HS.

Family and domain databases

ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  2. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors."
    Sun M., Ma L., Xu L., Li J., Zhang W., Petrovics G., Makarem M., Sesterhenn I., Zhang M., Blanchette-Mackie E.J., Moul J., Srivastava S., Zou Z.
    Mol. Med. 8:655-663(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast."
    Green A.R., Krivinskas S., Young P., Rakha E.A., Paish E.C., Powe D.G., Ellis I.O.
    Breast Cancer Res. Treat. 113:59-66(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.

Entry informationi

Entry nameiCTF8A_HUMAN
AccessioniPrimary (citable) accession number: P0CG12
Secondary accession number(s): A8MYX8
, Q71E72, Q8NDH8, Q8WV66, Q9NX73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 8, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Found in a common chromosomal region of deletion in breast cancer.

Caution

mRNA expression studied by PubMed:12477976 does not differentiate between isoform 1 and isoform 2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.