P0CG12 (CTF8A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chromosome transmission fidelity protein 8 homolog isoform 2

Alternative name(s):
Decreased expression in renal and prostate cancer protein

Gene names

Name:	CHTF8
Synonyms:	DERPC

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	524 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed. Ref.4
Subcellular location	Nucleus Ref.4.
Tissue specificity	Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer cells, between lobular carcinoma and normal lobules. Ref.4 Ref.5
Miscellaneous	Found in a common chromosomal region of deletion in breast cancer.
Sequence similarities	Belongs to the DERPC family.
Caution	mRNA expression studied by Ref.4 does not differentiate between isoform 1 and isoform 2.
Sequence caution	The sequence CAD38758.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: P0CG12-1)

Also known as: DERPC;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: P0CG13-1)

The sequence of this isoform can be found in the external entry P0CG13.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 524	524	Chromosome transmission fidelity protein 8 homolog isoform 2		PRO_0000326396
Regions
	Compositional bias	4 – 524	521	Pro-rich
	Compositional bias	101 – 328	228	Gly-rich

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 (DERPC) [UniParc]. Last modified June 15, 2010. Version 1. Checksum: C917FEEC7BC3702E	FASTA	524	51,391
	10 20 30 40 50 60 MKEPRIFPRE RPTPWTRAPL PPRGRLDGSL GPQGGPVLNT GHPLGVNSDP FLMAAGSLGG 70 80 90 100 110 120 NLTPFPRNPS PFPASSGSLA SNPAPFPAGA RDPSMASFPR GMNPTGTGAV SFPRPGGLLG 130 140 150 160 170 180 PGPGPGPTLN PRTGALPGPG PLSNPRLGGL PGPGPMSNPR AGGLLGAGPD PRGGGPMGPG 190 200 210 220 230 240 SGPNLRAGVL LTSGNGPPNP RPVGLGPGPN PNLRSGFLGT NPAPRSGVFP GPGLGPNPRP 250 260 270 280 290 300 SGLGPGPNLD ARAGGLLGTG SGLNLRMAGP QGLDLAPILR AAGLLGANSA SFSQASGNMG 310 320 330 340 350 360 TSPSSMARVP GPMGPNSGPS SRGIGLPGPN PSPMSRAPGP IGPNSAHFSR PVGPMGVNAN 370 380 390 400 410 420 PFPRGAGSSA FSQSSGTLAS NPATFQRSAG LQGSNPTIFP RASGPLGPNP ANFPRATGLQ 430 440 450 460 470 480 GPSPTTFPRS TGPLGPGQVT FPRPAAGHLG PSPAGPVGIN PAPFTRPTGT LGLNPASFPR 490 500 510 520 MNGPAGKSFV PFPRVGSLPG TNPAAFPRPG GPMAAMYPNG MLPP
	Isoform 1 [UniParc]. See P0CG13.		–	–

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[2]	"The sequence and analysis of duplication-rich human chromosome 16." Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J. , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A. Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"A human novel gene DERPC on 16q22.1 inhibits prostate tumor cell growth and its expression is decreased in prostate and renal tumors." Sun M., Ma L., Xu L., Li J., Zhang W., Petrovics G., Makarem M., Sesterhenn I., Zhang M., Blanchette-Mackie E.J., Moul J., Srivastava S., Zou Z. Mol. Med. 8:655-663(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]	"Loss of expression of chromosome 16q genes DPEP1 and CTCF in lobular carcinoma in situ of the breast." Green A.R., Krivinskas S., Young P., Rakha E.A., Paish E.C., Powe D.G., Ellis I.O. Breast Cancer Res. Treat. 113:59-66(2009) [PubMed] [Europe PMC] [Abstract] Cited for: TISSUE SPECIFICITY.
[6]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AL833902 mRNA. Translation: CAD38758.1. Different initiation. AC009027 Genomic DNA. No translation available. CH471092 Genomic DNA. Translation: EAW83250.1.
IPI	IPI00171540.
UniGene	Hs.85962.
3D structure databases
ProteinModelPortal	P0CG12.
ModBase	Search...
PTM databases
PhosphoSite	P0CG12.
Polymorphism databases
DMDM	298351628.
Proteomic databases
PRIDE	P0CG12.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000306585; ENSP00000305687; ENSG00000168802.
UCSC	uc002ewo.2. human.
Organism-specific databases
GeneCards	GC16M069151.
H-InvDB	HIX0013181.
HGNC	HGNC:24353. CHTF8.
HPA	HPA051872.
MIM	613202. gene.
neXtProt	NX_P0CG12.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HOG000243059.
OMA	NSDPFLM.
OrthoDB	EOG45DWPD.
Gene expression databases
ArrayExpress	P0CG12.
Bgee	P0CG12.
Family and domain databases
ProtoNet	Search...
Other
NextBio	57996.
SOURCE	Search...

Entry information

Entry name

CTF8A_HUMAN

Accession

Primary (citable) accession number: P0CG12
Secondary accession number(s): A8MYX8 , Q71E72, Q8NDH8, Q8WV66, Q9NX73

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 15, 2010
Last sequence update:	June 15, 2010
Last modified:	May 1, 2013
This is version 22 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.