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Protein

Golgi pH regulator B

Gene

GPR89B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:G66-32328-MONOMER.
ZFISH:G66-32998-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi pH regulator B
Alternative name(s):
Protein GPR89B
Gene namesi
Name:GPR89B
Synonyms:GPHRB, GPR89C
ORF Names:HSPC201
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:13840. GPR89B.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Transmembranei46 – 66HelicalSequence analysisAdd BLAST21
Transmembranei79 – 99HelicalSequence analysisAdd BLAST21
Transmembranei114 – 134HelicalSequence analysisAdd BLAST21
Transmembranei150 – 170HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei343 – 363HelicalSequence analysisAdd BLAST21
Transmembranei378 – 398HelicalSequence analysisAdd BLAST21
Transmembranei425 – 445HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000117262.
ENSG00000188092.
PharmGKBiPA134986137.
PA143485481.

Polymorphism and mutation databases

DMDMi298351693.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003950061 – 455Golgi pH regulator BAdd BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Glycosylationi243N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiP0CG08.
PeptideAtlasiP0CG08.
PRIDEiP0CG08.

PTM databases

iPTMnetiP0CG08.
PhosphoSitePlusiP0CG08.
SwissPalmiP0CG08.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiENSG00000188092.
ExpressionAtlasiP0CG08. baseline and differential.
GenevisibleiP0CG08. HS.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi119554. 16 interactors.
575849. 36 interactors.
STRINGi9606.ENSP00000358233.

Structurei

3D structure databases

ProteinModelPortaliP0CG08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2417. Eukaryota.
ENOG410XQ8R. LUCA.
GeneTreeiENSGT00390000000684.
HOGENOMiHOG000240999.
HOVERGENiHBG054909.
InParanoidiP0CG08.
OrthoDBiEOG091G06HP.
PhylomeDBiP0CG08.
TreeFamiTF313484.

Family and domain databases

InterProiIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR/GTG.
[Graphical view]
PANTHERiPTHR15948. PTHR15948. 1 hit.
PfamiPF12430. ABA_GPCR. 1 hit.
PF12537. GPHR_N. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CG08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF
60 70 80 90 100
SCTMFELIIF EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS
110 120 130 140 150
NIRLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV
160 170 180 190 200
GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI
210 220 230 240 250
ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG SENLTLIQQE
260 270 280 290 300
VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK
310 320 330 340 350
IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI
360 370 380 390 400
IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM
410 420 430 440 450
SMPLEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE

KQMAP
Length:455
Mass (Da):52,917
Last modified:June 15, 2010 - v1
Checksum:iD831F66E682643F9
GO

Sequence cautioni

The sequence AAF36121 differs from that shown. Reason: Erroneous termination at position 297. Translated as Cys.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti244 – 247LTLI → NTMA in CAH56393 (PubMed:17974005).Curated4
Sequence conflicti251V → E in AAF36121 (PubMed:11042152).Curated1
Sequence conflicti418Q → R in AAF36121 (PubMed:11042152).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78723 mRNA. Translation: AAF21463.1.
AL356004 Genomic DNA. Translation: CAI17085.1.
AL445591, BX537254 Genomic DNA. Translation: CAH72386.1.
BX537254, AL445591 Genomic DNA. Translation: CAI18821.1.
AL133020 mRNA. Translation: CAH56393.1.
AF151035 mRNA. Translation: AAF36121.1. Sequence problems.
CCDSiCCDS930.1.
RefSeqiNP_001091081.1. NM_001097612.1.
NP_057418.1. NM_016334.3.
XP_005277458.1. XM_005277401.3.
XP_006711555.1. XM_006711492.3.
XP_011507915.1. XM_011509613.2.
XP_011508212.1. XM_011509910.2.
UniGeneiHs.504320.
Hs.559115.
Hs.645432.
Hs.680770.

Genome annotation databases

EnsembliENST00000314163; ENSP00000358233; ENSG00000188092.
GeneIDi51463.
653519.
KEGGihsa:51463.
hsa:653519.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78723 mRNA. Translation: AAF21463.1.
AL356004 Genomic DNA. Translation: CAI17085.1.
AL445591, BX537254 Genomic DNA. Translation: CAH72386.1.
BX537254, AL445591 Genomic DNA. Translation: CAI18821.1.
AL133020 mRNA. Translation: CAH56393.1.
AF151035 mRNA. Translation: AAF36121.1. Sequence problems.
CCDSiCCDS930.1.
RefSeqiNP_001091081.1. NM_001097612.1.
NP_057418.1. NM_016334.3.
XP_005277458.1. XM_005277401.3.
XP_006711555.1. XM_006711492.3.
XP_011507915.1. XM_011509613.2.
XP_011508212.1. XM_011509910.2.
UniGeneiHs.504320.
Hs.559115.
Hs.645432.
Hs.680770.

3D structure databases

ProteinModelPortaliP0CG08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119554. 16 interactors.
575849. 36 interactors.
STRINGi9606.ENSP00000358233.

PTM databases

iPTMnetiP0CG08.
PhosphoSitePlusiP0CG08.
SwissPalmiP0CG08.

Polymorphism and mutation databases

DMDMi298351693.

Proteomic databases

PaxDbiP0CG08.
PeptideAtlasiP0CG08.
PRIDEiP0CG08.

Protocols and materials databases

DNASUi51463.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000314163; ENSP00000358233; ENSG00000188092.
GeneIDi51463.
653519.
KEGGihsa:51463.
hsa:653519.

Organism-specific databases

CTDi51463.
653519.
GeneCardsiGPR89B.
H-InvDBHIX0000982.
HIX0056760.
HIX0159660.
HGNCiHGNC:13840. GPR89B.
MIMi612806. gene.
neXtProtiNX_P0CG08.
OpenTargetsiENSG00000117262.
ENSG00000188092.
PharmGKBiPA134986137.
PA143485481.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2417. Eukaryota.
ENOG410XQ8R. LUCA.
GeneTreeiENSGT00390000000684.
HOGENOMiHOG000240999.
HOVERGENiHBG054909.
InParanoidiP0CG08.
OrthoDBiEOG091G06HP.
PhylomeDBiP0CG08.
TreeFamiTF313484.

Enzyme and pathway databases

BioCyciZFISH:G66-32328-MONOMER.
ZFISH:G66-32998-MONOMER.

Miscellaneous databases

PROiP0CG08.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000188092.
ExpressionAtlasiP0CG08. baseline and differential.
GenevisibleiP0CG08. HS.

Family and domain databases

InterProiIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR/GTG.
[Graphical view]
PANTHERiPTHR15948. PTHR15948. 1 hit.
PfamiPF12430. ABA_GPCR. 1 hit.
PF12537. GPHR_N. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGPHRB_HUMAN
AccessioniPrimary (citable) accession number: P0CG08
Secondary accession number(s): A6NKF9
, A6NN37, B2RUV3, B3KMN3, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: November 2, 2016
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Does not seem to be able to bind GTP.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.