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P0CG08

- GPHRB_HUMAN

UniProt

P0CG08 - GPHRB_HUMAN

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Protein

Golgi pH regulator B

Gene

GPR89B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.By similarity

GO - Molecular functioni

  1. voltage-gated ion channel activity Source: UniProtKB-KW

GO - Biological processi

  1. protein transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Protein transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Golgi pH regulator B
Alternative name(s):
Protein GPR89B
Gene namesi
Name:GPR89B
Synonyms:GPHRB
ORF Names:HSPC201
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:13840. GPR89B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence AnalysisAdd
BLAST
Transmembranei46 – 6621HelicalSequence AnalysisAdd
BLAST
Transmembranei79 – 9921HelicalSequence AnalysisAdd
BLAST
Transmembranei114 – 13421HelicalSequence AnalysisAdd
BLAST
Transmembranei150 – 17021HelicalSequence AnalysisAdd
BLAST
Transmembranei290 – 31021HelicalSequence AnalysisAdd
BLAST
Transmembranei343 – 36321HelicalSequence AnalysisAdd
BLAST
Transmembranei378 – 39821HelicalSequence AnalysisAdd
BLAST
Transmembranei425 – 44521HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134986137.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Golgi pH regulator BPRO_0000395006Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP0CG08.

Expressioni

Tissue specificityi

Ubiquitous.1 Publication

Gene expression databases

BgeeiP0CG08.
ExpressionAtlasiP0CG08. baseline.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

BioGridi119554. 1 interaction.
575849. 8 interactions.

Structurei

3D structure databases

ProteinModelPortaliP0CG08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiP0CG08.
OrthoDBiEOG7HHWRV.
PhylomeDBiP0CG08.
TreeFamiTF313484.

Family and domain databases

InterProiIPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR.
[Graphical view]
PANTHERiPTHR15948. PTHR15948. 1 hit.
PfamiPF12430. ABA_GPCR. 1 hit.
PF12537. DUF3735. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CG08-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF
60 70 80 90 100
SCTMFELIIF EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS
110 120 130 140 150
NIRLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV
160 170 180 190 200
GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI
210 220 230 240 250
ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG SENLTLIQQE
260 270 280 290 300
VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK
310 320 330 340 350
IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI
360 370 380 390 400
IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM
410 420 430 440 450
SMPLEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE

KQMAP
Length:455
Mass (Da):52,917
Last modified:June 15, 2010 - v1
Checksum:iD831F66E682643F9
GO

Sequence cautioni

The sequence AAF36121.1 differs from that shown. Reason: Erroneous termination at position 297. Translated as Cys.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2474LTLI → NTMA in CAH56393. (PubMed:17974005)Curated
Sequence conflicti251 – 2511V → E in AAF36121. (PubMed:11042152)Curated
Sequence conflicti418 – 4181Q → R in AAF36121. (PubMed:11042152)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78723 mRNA. Translation: AAF21463.1.
AL445591, BX537254 Genomic DNA. Translation: CAH72386.1.
BX537254, AL445591 Genomic DNA. Translation: CAI18821.1.
AL133020 mRNA. Translation: CAH56393.1.
AF151035 mRNA. Translation: AAF36121.1. Sequence problems.
CCDSiCCDS930.1.
RefSeqiNP_001091081.1. NM_001097612.1.
NP_057418.1. NM_016334.3.
XP_005277458.1. XM_005277401.2.
XP_006711555.1. XM_006711492.1.
UniGeneiHs.504320.
Hs.559115.
Hs.645432.

Genome annotation databases

EnsembliENST00000314163; ENSP00000358233; ENSG00000188092.
GeneIDi51463.
653519.
KEGGihsa:51463.
hsa:653519.

Polymorphism databases

DMDMi298351693.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U78723 mRNA. Translation: AAF21463.1 .
AL445591 , BX537254 Genomic DNA. Translation: CAH72386.1 .
BX537254 , AL445591 Genomic DNA. Translation: CAI18821.1 .
AL133020 mRNA. Translation: CAH56393.1 .
AF151035 mRNA. Translation: AAF36121.1 . Sequence problems.
CCDSi CCDS930.1.
RefSeqi NP_001091081.1. NM_001097612.1.
NP_057418.1. NM_016334.3.
XP_005277458.1. XM_005277401.2.
XP_006711555.1. XM_006711492.1.
UniGenei Hs.504320.
Hs.559115.
Hs.645432.

3D structure databases

ProteinModelPortali P0CG08.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 119554. 1 interaction.
575849. 8 interactions.

Polymorphism databases

DMDMi 298351693.

Proteomic databases

PRIDEi P0CG08.

Protocols and materials databases

DNASUi 51463.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000314163 ; ENSP00000358233 ; ENSG00000188092 .
GeneIDi 51463.
653519.
KEGGi hsa:51463.
hsa:653519.

Organism-specific databases

CTDi 51463.
653519.
GeneCardsi GC01P147400.
H-InvDB HIX0000982.
HIX0056760.
HIX0159660.
HGNCi HGNC:13840. GPR89B.
MIMi 612806. gene.
neXtProti NX_P0CG08.
PharmGKBi PA134986137.
GenAtlasi Search...

Phylogenomic databases

InParanoidi P0CG08.
OrthoDBi EOG7HHWRV.
PhylomeDBi P0CG08.
TreeFami TF313484.

Miscellaneous databases

NextBioi 55087.
PROi P0CG08.
SOURCEi Search...

Gene expression databases

Bgeei P0CG08.
ExpressionAtlasi P0CG08. baseline.

Family and domain databases

InterProi IPR025969. ABA_GPCR_dom.
IPR022535. Golgi_pH-regulator_cons_dom.
IPR015672. GPHR.
[Graphical view ]
PANTHERi PTHR15948. PTHR15948. 1 hit.
Pfami PF12430. ABA_GPCR. 1 hit.
PF12537. DUF3735. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of 15 genes mapping to chromosome 6p21.3 spanning the microsatellite markers D6S306 and D6S1260. Characterization of three genes encoding zinc finger proteins."
    Lee P.L., Gelbart T., West C., Adams M., Blackstone R., Meyer A.
    Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Ovary.
  2. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-247.
    Tissue: Testis.
  4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
    Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
    , Gu J., Chen S.-J., Chen Z.
    Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 249-455.
    Tissue: Umbilical cord blood.
  5. "GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus."
    Maeda Y., Ide T., Koike M., Uchiyama Y., Kinoshita T.
    Nat. Cell Biol. 10:1135-1145(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY.
  6. "Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis."
    Pandey S., Nelson D.C., Assmann S.M.
    Cell 136:136-148(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: LACK OF GTP-BINDING.

Entry informationi

Entry nameiGPHRB_HUMAN
AccessioniPrimary (citable) accession number: P0CG08
Secondary accession number(s): A6NN37
, B2RUV3, B3KMN3, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: October 29, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Does not seem to be able to bind GTP.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3