Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P0CG08

- GPHRB_HUMAN

UniProt

P0CG08 - GPHRB_HUMAN

Protein

Golgi pH regulator B

Gene

GPR89B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 30 (01 Oct 2014)
      Sequence version 1 (15 Jun 2010)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance.By similarity

    GO - Molecular functioni

    1. voltage-gated ion channel activity Source: UniProtKB-KW

    GO - Biological processi

    1. protein transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Protein transport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Golgi pH regulator B
    Alternative name(s):
    Protein GPR89B
    Gene namesi
    Name:GPR89B
    Synonyms:GPHRB
    ORF Names:HSPC201
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:13840. GPR89B.

    Subcellular locationi

    GO - Cellular componenti

    1. Golgi membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Golgi apparatus, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134986137.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Golgi pH regulator BPRO_0000395006Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PRIDEiP0CG08.

    Expressioni

    Tissue specificityi

    Ubiquitous.1 Publication

    Gene expression databases

    BgeeiP0CG08.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Protein-protein interaction databases

    BioGridi119554. 1 interaction.
    575849. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP0CG08.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei5 – 2521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei46 – 6621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei79 – 9921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei114 – 13421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei150 – 17021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei290 – 31021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei343 – 36321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei378 – 39821HelicalSequence AnalysisAdd
    BLAST
    Transmembranei425 – 44521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    OrthoDBiEOG7HHWRV.
    PhylomeDBiP0CG08.
    TreeFamiTF313484.

    Family and domain databases

    InterProiIPR025969. ABA_GPCR_dom.
    IPR022535. Golgi_pH-regulator_cons_dom.
    IPR015672. GPHR.
    [Graphical view]
    PANTHERiPTHR15948. PTHR15948. 1 hit.
    PfamiPF12430. ABA_GPCR. 1 hit.
    PF12537. DUF3735. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CG08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSFLIDSSIM ITSQILFFGF GWLFFMRQLF KDYEIRQYVV QVIFSVTFAF    50
    SCTMFELIIF EILGVLNSSS RYFHWKMNLC VILLILVFMV PFYIGYFIVS 100
    NIRLLHKQRL LFSCLLWLTF MYFFWKLGDP FPILSPKHGI LSIEQLISRV 150
    GVIGVTLMAL LSGFGAVNCP YTYMSYFLRN VTDTDILALE RRLLQTMDMI 200
    ISKKKRMAMA RRTMFQKGEV HNKPSGFWGM IKSVTTSASG SENLTLIQQE 250
    VDALEELSRQ LFLETADLYA TKERIEYSKT FKGKYFNFLG YFFSIYCVWK 300
    IFMATINIVF DRVGKTDPVT RGIEITVNYL GIQFDVKFWS QHISFILVGI 350
    IIVTSIRGLL ITLTKFFYAI SSSKSSNVIV LLLAQIMGMY FVSSVLLIRM 400
    SMPLEYRTII TEVLGELQFN FYHRWFDVIF LVSALSSILF LYLAHKQAPE 450
    KQMAP 455
    Length:455
    Mass (Da):52,917
    Last modified:June 15, 2010 - v1
    Checksum:iD831F66E682643F9
    GO

    Sequence cautioni

    The sequence AAF36121.1 differs from that shown. Reason: Erroneous termination at position 297. Translated as Cys.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti244 – 2474LTLI → NTMA in CAH56393. (PubMed:17974005)Curated
    Sequence conflicti251 – 2511V → E in AAF36121. (PubMed:11042152)Curated
    Sequence conflicti418 – 4181Q → R in AAF36121. (PubMed:11042152)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78723 mRNA. Translation: AAF21463.1.
    AL445591, BX537254 Genomic DNA. Translation: CAH72386.1.
    BX537254, AL445591 Genomic DNA. Translation: CAI18821.1.
    AL133020 mRNA. Translation: CAH56393.1.
    AF151035 mRNA. Translation: AAF36121.1. Sequence problems.
    CCDSiCCDS930.1.
    RefSeqiNP_001091081.1. NM_001097612.1.
    NP_057418.1. NM_016334.3.
    XP_005277458.1. XM_005277401.2.
    XP_006711555.1. XM_006711492.1.
    UniGeneiHs.504320.
    Hs.559115.
    Hs.645432.

    Genome annotation databases

    EnsembliENST00000314163; ENSP00000358233; ENSG00000188092.
    GeneIDi51463.
    653519.
    KEGGihsa:51463.
    hsa:653519.

    Polymorphism databases

    DMDMi298351693.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U78723 mRNA. Translation: AAF21463.1 .
    AL445591 , BX537254 Genomic DNA. Translation: CAH72386.1 .
    BX537254 , AL445591 Genomic DNA. Translation: CAI18821.1 .
    AL133020 mRNA. Translation: CAH56393.1 .
    AF151035 mRNA. Translation: AAF36121.1 . Sequence problems.
    CCDSi CCDS930.1.
    RefSeqi NP_001091081.1. NM_001097612.1.
    NP_057418.1. NM_016334.3.
    XP_005277458.1. XM_005277401.2.
    XP_006711555.1. XM_006711492.1.
    UniGenei Hs.504320.
    Hs.559115.
    Hs.645432.

    3D structure databases

    ProteinModelPortali P0CG08.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 119554. 1 interaction.
    575849. 1 interaction.

    Polymorphism databases

    DMDMi 298351693.

    Proteomic databases

    PRIDEi P0CG08.

    Protocols and materials databases

    DNASUi 51463.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000314163 ; ENSP00000358233 ; ENSG00000188092 .
    GeneIDi 51463.
    653519.
    KEGGi hsa:51463.
    hsa:653519.

    Organism-specific databases

    CTDi 51463.
    653519.
    GeneCardsi GC01P147400.
    H-InvDB HIX0000982.
    HIX0056760.
    HIX0159660.
    HGNCi HGNC:13840. GPR89B.
    MIMi 612806. gene.
    neXtProti NX_P0CG08.
    PharmGKBi PA134986137.
    GenAtlasi Search...

    Phylogenomic databases

    OrthoDBi EOG7HHWRV.
    PhylomeDBi P0CG08.
    TreeFami TF313484.

    Miscellaneous databases

    NextBioi 55087.
    PROi P0CG08.
    SOURCEi Search...

    Gene expression databases

    Bgeei P0CG08.

    Family and domain databases

    InterProi IPR025969. ABA_GPCR_dom.
    IPR022535. Golgi_pH-regulator_cons_dom.
    IPR015672. GPHR.
    [Graphical view ]
    PANTHERi PTHR15948. PTHR15948. 1 hit.
    Pfami PF12430. ABA_GPCR. 1 hit.
    PF12537. DUF3735. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of 15 genes mapping to chromosome 6p21.3 spanning the microsatellite markers D6S306 and D6S1260. Characterization of three genes encoding zinc finger proteins."
      Lee P.L., Gelbart T., West C., Adams M., Blackstone R., Meyer A.
      Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Ovary.
    2. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-247.
      Tissue: Testis.
    4. "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells."
      Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G., Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W., Tao J., Huang Q.-H., Zhou J., Hu G.-X.
      , Gu J., Chen S.-J., Chen Z.
      Genome Res. 10:1546-1560(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 249-455.
      Tissue: Umbilical cord blood.
    5. "GPHR is a novel anion channel critical for acidification and functions of the Golgi apparatus."
      Maeda Y., Ide T., Koike M., Uchiyama Y., Kinoshita T.
      Nat. Cell Biol. 10:1135-1145(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, TISSUE SPECIFICITY.
    6. "Two novel GPCR-type G proteins are abscisic acid receptors in Arabidopsis."
      Pandey S., Nelson D.C., Assmann S.M.
      Cell 136:136-148(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: LACK OF GTP-BINDING.

    Entry informationi

    Entry nameiGPHRB_HUMAN
    AccessioniPrimary (citable) accession number: P0CG08
    Secondary accession number(s): A6NN37
    , B2RUV3, B3KMN3, Q53FQ9, Q5T2V8, Q5T5P5, Q659E2, Q6NVY5, Q9P0S4, Q9Y302
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Does not seem to be able to bind GTP.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3