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Protein

Ig lambda-3 chain C regions

Gene

IGLC3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Bence-Jones protein

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig lambda-3 chain C regions
Gene namesi
Name:IGLC3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5857. IGLC3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi298351715.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 106›106Ig lambda-3 chain C regionsPRO_0000394666Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 87
Disulfide bondi105 – 105Interchain (with heavy chain)

Keywords - PTMi

Disulfide bond

Proteomic databases

EPDiP0CG06.
MaxQBiP0CG06.
PRIDEiP0CG06.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP0CG06. 1 interaction.

Structurei

Secondary structure

1
106
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 125Combined sources
Helixi16 – 205Combined sources
Beta strandi24 – 3613Combined sources
Beta strandi39 – 446Combined sources
Beta strandi47 – 493Combined sources
Beta strandi53 – 553Combined sources
Beta strandi66 – 749Combined sources
Helixi76 – 816Combined sources
Beta strandi85 – 917Combined sources
Beta strandi94 – 1007Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AQKX-ray1.84L1-106[»]
7FABX-ray2.00L2-106[»]
ProteinModelPortaliP0CG06.
SMRiP0CG06. Positions 1-105.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CG06.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 10195Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

InParanoidiP0CG06.
PhylomeDBiP0CG06.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CG06-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GQPKAAPSVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADSSPAK
60 70 80 90 100
AGVETTTPSK QSNNKYAASS YLSLTPEQWK SHKSYSCQVT HEGSTVEKTV

APTECS
Length:106
Mass (Da):11,238
Last modified:June 15, 2010 - v1
Checksum:i144565BBF1484565
GO

Sequence cautioni

The sequence AAA59109.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAB36581.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence CAA36051.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00254 Genomic DNA. Translation: AAA59109.1. Different initiation.
X51755 Genomic DNA. Translation: CAA36051.1. Different initiation.
L38562 mRNA. Translation: AAB36581.1. Different initiation.
PIRiA92057. L2HU.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J00254 Genomic DNA. Translation: AAA59109.1. Different initiation.
X51755 Genomic DNA. Translation: CAA36051.1. Different initiation.
L38562 mRNA. Translation: AAB36581.1. Different initiation.
PIRiA92057. L2HU.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AQKX-ray1.84L1-106[»]
7FABX-ray2.00L2-106[»]
ProteinModelPortaliP0CG06.
SMRiP0CG06. Positions 1-105.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0CG06. 1 interaction.

Protein family/group databases

IMGTiSearch...
Search...
Search...

Polymorphism and mutation databases

DMDMi298351715.

Proteomic databases

EPDiP0CG06.
MaxQBiP0CG06.
PRIDEiP0CG06.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiIGLC3.
HGNCiHGNC:5857. IGLC3.
neXtProtiNX_P0CG06.
GenAtlasiSearch...

Phylogenomic databases

InParanoidiP0CG06.
PhylomeDBiP0CG06.

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

EvolutionaryTraceiP0CG06.
PROiP0CG06.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Amino acid sequence of the (lambda) light chain of a human myeloma immunoglobulin (IgG New)."
    Chen B.L., Poljak R.J.
    Biochemistry 13:1295-1302(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: PARTIAL PROTEIN SEQUENCE (MYELOMA PROTEIN NEWM).
  2. "Clustered arrangement of immunoglobulin lambda constant region genes in man."
    Hieter P.A., Hollis G.F., Korsmeyer S.J., Waldmann T.A., Leder P.
    Nature 294:536-540(1981) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structure and expression of the human immunoglobulin lambda genes."
    Vasicek T.J., Leder P.
    J. Exp. Med. 172:609-620(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Characterization of the two unique human anti-flavin monoclonal immunoglobulins."
    Stoppini M., Bellotti V., Negri A., Merlini G., Garver F., Ferri G.
    Eur. J. Biochem. 228:886-893(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (DOT).
  5. "Recombinant human Fab antibody fragments to HIV-1 Rev and Tat regulatory proteins: direct selection from a combinatorial phage display library."
    Pilkington G.R., Duan L., Zhu M., Keil W., Pomerantz R.J.
    Mol. Immunol. 33:439-450(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  6. "The three-dimensional structure of the fab' fragment of a human myeloma immunoglobulin at 2.0-A resolution."
    Poljak R.J., Amzel L.M., Avey H.P., Chen B.L., Phizackerley R.P., Saul F.
    Proc. Natl. Acad. Sci. U.S.A. 71:3440-3444(1974) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF NEWM.
  7. "Immunoglobulin lambda (IGL) genes of human and mouse."
    Lefranc M.-P., Lefranc G.
    (In) Honjo T., Alt F.W., Neuberger M. (eds.); Molecular Biology of B Cells, pp.37-59, Elsevier Academic Press, London (2004)
    Cited for: SEROLOGICAL ISOTYPE.

Entry informationi

Entry nameiLAC3_HUMAN
AccessioniPrimary (citable) accession number: P0CG06
Secondary accession number(s): A0M8Q4, P80423
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: June 8, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Alleles IGLC3*01, IGLC3*02, and IGLC3*03 display the following serological isotype: Mcg-, Kern- and Oz+. The Mcg-isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz+ marker by Lys-83. Allele IGLC3*04 displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.