P0CG05 (LAC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ig lambda-2 chain C regions

Gene names

Name:

IGLC2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	Displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.
Sequence caution	The sequence AAA59107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA20015.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA20026.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence BAA20028.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAA36049.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAB38569.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence EAW59547.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence EAW59549.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Domain	Immunoglobulin C region Immunoglobulin domain
Molecular function	Bence-Jones protein
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular_component	extracellular region Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antigen binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 106

›106

Ig lambda-2 chain C regions

PRO_0000394665

Regions

Domain

7 – 101

95

Ig-like

Amino acid modifications

Disulfide bond

28 ↔ 87

Ref.1

Disulfide bond

105

Interchain (with heavy chain) Ref.1

Experimental info

Non-terminal residue

1

1

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

106

Helix Strand Turn

Details...

Beta strand

8 – 12

5

Helix

16 – 20

5

Beta strand

24 – 36

13

Beta strand

39 – 44

6

Beta strand

47 – 49

3

Beta strand

53 – 55

3

Beta strand

66 – 74

9

Helix

76 – 81

6

Beta strand

85 – 91

7

Beta strand

94 – 100

7

Sequences

	Sequence		Length	Mass (Da)
	P0CG05 [UniParc]. Last modified June 15, 2010. Version 1. Checksum: E5DB72BBE65F4577	FASTA	106	11,294
	10 20 30 40 50 60 GQPKAAPSVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADSSPVK AGVETTTPSK 70 80 90 100 QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV APTECS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Immunoglobulin lambda-chains. The complete amino acid sequence of a Bence-Jones protein." Milstein C., Clegg J.B., Jarvis J.M. Biochem. J. 110:631-652(1968) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN X), DISULFIDE BONDS.
[2]	"The amino acid sequence of a lambda type Bence-Jones protein. 3. The complete amino acid sequence and the location of the disulfide bridges." Titani K., Wikler M., Shinoda T., Putnam F.W. J. Biol. Chem. 245:2171-2176(1970) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN SH).
[3]	"Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones-protein Kern). V. The complete amino acid sequence and its genetic interpretation." Ponstingl H., Hess M., Hilschmann N. Hoppe-Seyler's Z. Physiol. Chem. 352:247-266(1971) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN KERN).
[4]	"Clustered arrangement of immunoglobulin lambda constant region genes in man." Hieter P.A., Hollis G.F., Korsmeyer S.J., Waldmann T.A., Leder P. Nature 294:536-540(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]	"Comparative studies on the structure of the light chains of human immunoglobulins. IV. Assignment of a subsubgroup." Kametani F., Takayasu T., Suzuki S., Shinoda T., Okuyama T., Shimizu A. J. Biochem. 93:421-429(1983) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN NIG-64).
[6]	"Structure and expression of the human immunoglobulin lambda genes." Vasicek T.J., Leder P. J. Exp. Med. 172:609-620(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]	"One-megabase sequence analysis of the human immunoglobulin lambda gene locus." Kawasaki K., Minoshima S., Nakato E., Shibuya K., Shintani A., Schmeits J.L., Wang J., Shimizu N. Genome Res. 7:250-261(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"Immunoglobulin lambda (IGL) genes of human and mouse." Lefranc M.-P., Lefranc G. (In) Honjo T., Alt F.W., Neuberger M. (eds.); Molecular Biology of B Cells, pp.37-59, Elsevier Academic Press, London (2004) Cited for: SEROLOGICAL ISOTYPE.
+	Additional computationally mapped references.

Web resources

IMGT/GENE-DB

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

J00253 Genomic DNA. Translation: AAA59107.1. Different initiation.
X51754 Genomic DNA. Translation: CAB38569.1. Different initiation.
X51755 Genomic DNA. Translation: CAA36049.1. Different initiation.
D87017 Genomic DNA. Translation: BAA20015.1. Different initiation.
D87023 Genomic DNA. Translation: BAA20026.1. Different initiation.
D87023 Genomic DNA. Translation: BAA20028.1. Different initiation.
CH471095 Genomic DNA. Translation: EAW59547.1. Different initiation.
CH471095 Genomic DNA. Translation: EAW59549.1. Different initiation.

IPI

IPI00154742.

PIR

L2HU. A92057.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1JVK	X-ray	1.94	B	1-105	[»]
1LIL	X-ray	2.65	A/B	1-106	[»]
1ZVO	X-ray	-	A/B	2-106	[»]
2JB5	X-ray	2.80	L	1-104	[»]
2JB6	X-ray	2.85	A/L	1-104	[»]
3C2A	X-ray	2.10	L/M	1-105	[»]
3TV3	X-ray	1.29	L	1-106	[»]
3TWC	X-ray	1.65	L	1-106	[»]
3TYG	X-ray	3.25	L	1-106	[»]
4EOW	X-ray	1.97	L	1-106	[»]

ProteinModelPortal

P0CG05.

SMR

P0CG05. Positions 1-102.

ModBase

Search...

Protein-protein interaction databases

IntAct

P0CG05. 1 interaction.

Protein family/group databases

IMGT

Search...
Search...
Search...
Search...
Search...
Search...
Search...
Search...

Polymorphism databases

DMDM

298351714.

Proteomic databases

PRIDE

P0CG05.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

GeneCards

GC22P023243.

H-InvDB

HIX0016285.
HIX0197173.

HGNC

HGNC:5856. IGLC2.

neXtProt

NX_P0CG05.

GenAtlas

Search...

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

GermOnline

ENSG00000100208. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P0CG05.

Entry information

Entry name

LAC2_HUMAN

Accession

Primary (citable) accession number: P0CG05
Secondary accession number(s): A0M8Q4, P80423

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 15, 2010
Last sequence update:	June 15, 2010
Last modified:	April 3, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.