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P0CG05 (LAC2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig lambda-2 chain C regions
Gene names
Name:IGLC2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length106 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

Displays the following serological isotype: Mcg-, Kern- and Oz-. The Mcg- isotype marker is characterized by Ala-6, Ser-8 and Thr-57; the Ke- marker by Ser-46 and the Oz- marker by Arg-83.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Sequence caution

The sequence AAA59107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAA20015.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAA20026.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence BAA20028.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAA36049.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAB38569.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

The sequence EAW59547.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence EAW59549.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 106›106Ig lambda-2 chain C regions
PRO_0000394665

Regions

Domain7 – 10195Ig-like

Amino acid modifications

Disulfide bond28 ↔ 87 Ref.1
Disulfide bond105Interchain (with heavy chain) Ref.1

Experimental info

Non-terminal residue11

Secondary structure

......................... 106
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0CG05 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: E5DB72BBE65F4577

FASTA10611,294
        10         20         30         40         50         60 
GQPKAAPSVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADSSPVK AGVETTTPSK 

        70         80         90        100 
QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV APTECS 

« Hide

References

« Hide 'large scale' references
[1]"Immunoglobulin lambda-chains. The complete amino acid sequence of a Bence-Jones protein."
Milstein C., Clegg J.B., Jarvis J.M.
Biochem. J. 110:631-652(1968) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN X), DISULFIDE BONDS.
[2]"The amino acid sequence of a lambda type Bence-Jones protein. 3. The complete amino acid sequence and the location of the disulfide bridges."
Titani K., Wikler M., Shinoda T., Putnam F.W.
J. Biol. Chem. 245:2171-2176(1970) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN SH).
[3]"Structural rule of antibodies. Primary structure of a monoclonal immunoglobulin-L-chain of the lambda type, subgroup IV (Bence-Jones-protein Kern). V. The complete amino acid sequence and its genetic interpretation."
Ponstingl H., Hess M., Hilschmann N.
Hoppe-Seyler's Z. Physiol. Chem. 352:247-266(1971) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN KERN).
[4]"Clustered arrangement of immunoglobulin lambda constant region genes in man."
Hieter P.A., Hollis G.F., Korsmeyer S.J., Waldmann T.A., Leder P.
Nature 294:536-540(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Comparative studies on the structure of the light chains of human immunoglobulins. IV. Assignment of a subsubgroup."
Kametani F., Takayasu T., Suzuki S., Shinoda T., Okuyama T., Shimizu A.
J. Biochem. 93:421-429(1983) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN NIG-64).
[6]"Structure and expression of the human immunoglobulin lambda genes."
Vasicek T.J., Leder P.
J. Exp. Med. 172:609-620(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[7]"One-megabase sequence analysis of the human immunoglobulin lambda gene locus."
Kawasaki K., Minoshima S., Nakato E., Shibuya K., Shintani A., Schmeits J.L., Wang J., Shimizu N.
Genome Res. 7:250-261(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]"Immunoglobulin lambda (IGL) genes of human and mouse."
Lefranc M.-P., Lefranc G.
(In) Honjo T., Alt F.W., Neuberger M. (eds.); Molecular Biology of B Cells, pp.37-59, Elsevier Academic Press, London (2004)
Cited for: SEROLOGICAL ISOTYPE.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
J00253 Genomic DNA. Translation: AAA59107.1. Different initiation.
X51754 Genomic DNA. Translation: CAB38569.1. Different initiation.
X51755 Genomic DNA. Translation: CAA36049.1. Different initiation.
D87017 Genomic DNA. Translation: BAA20015.1. Different initiation.
D87023 Genomic DNA. Translation: BAA20026.1. Different initiation.
D87023 Genomic DNA. Translation: BAA20028.1. Different initiation.
CH471095 Genomic DNA. Translation: EAW59547.1. Different initiation.
CH471095 Genomic DNA. Translation: EAW59549.1. Different initiation.
PIRL2HU. A92057.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1JVKX-ray1.94B1-105[»]
1LILX-ray2.65A/B1-106[»]
1ZVOX-ray-A/B2-106[»]
2JB5X-ray2.80L1-104[»]
2JB6X-ray2.85A/L1-104[»]
3C2AX-ray2.10L/M2-105[»]
3TV3X-ray1.29L1-106[»]
3TWCX-ray1.65L1-106[»]
3TYGX-ray3.25L1-106[»]
4EOWX-ray1.97L1-106[»]
4LLDX-ray1.19B1-105[»]
4LLMX-ray1.75B1-105[»]
4LLQX-ray1.42B1-105[»]
4LLUX-ray2.16B/D1-105[»]
4LLWX-ray1.95B/D1-105[»]
4LLYX-ray1.60B/D1-105[»]
4O58X-ray2.75L1-106[»]
4O5IX-ray6.50N/P/R/T/V/X1-106[»]
ProteinModelPortalP0CG05.
SMRP0CG05. Positions 2-102.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP0CG05. 1 interaction.

Protein family/group databases

IMGTSearch...
Search...
Search...
Search...
Search...
Search...
Search...
Search...

Polymorphism databases

DMDM298351714.

Proteomic databases

PRIDEP0CG05.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC22P023243.
H-InvDBHIX0016285.
HIX0197173.
HGNCHGNC:5856. IGLC2.
neXtProtNX_P0CG05.
GenAtlasSearch...

Phylogenomic databases

PhylomeDBP0CG05.

Enzyme and pathway databases

ReactomeREACT_160300. Binding and Uptake of Ligands by Scavenger Receptors.
REACT_6900. Immune System.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0CG05.
PROP0CG05.

Entry information

Entry nameLAC2_HUMAN
AccessionPrimary (citable) accession number: P0CG05
Secondary accession number(s): A0M8Q4, P80423
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: July 9, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM