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P0CG04

- LAC1_HUMAN

UniProt

P0CG04 - LAC1_HUMAN

Protein

Ig lambda-1 chain C regions

Gene

IGLC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    GO - Molecular functioni

    1. antigen binding Source: UniProtKB

    GO - Biological processi

    1. complement activation Source: Reactome
    2. complement activation, classical pathway Source: Reactome
    3. Fc-epsilon receptor signaling pathway Source: Reactome
    4. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
    5. immune response Source: UniProtKB
    6. innate immune response Source: Reactome
    7. regulation of immune response Source: Reactome

    Keywords - Molecular functioni

    Bence-Jones protein

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_160163. Scavenging of heme from plasma.
    REACT_160274. FCGR activation.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    REACT_7956. Classical antibody-mediated complement activation.
    REACT_8024. Initial triggering of complement.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ig lambda-1 chain C regions
    Gene namesi
    Name:IGLC1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:5855. IGLC1.

    Subcellular locationi

    GO - Cellular componenti

    1. blood microparticle Source: UniProt
    2. extracellular region Source: Reactome
    3. extracellular space Source: UniProt
    4. extracellular vesicular exosome Source: UniProt
    5. plasma membrane Source: Reactome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 106›106Ig lambda-1 chain C regionsPRO_0000153607Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi28 ↔ 87
    Disulfide bondi105 – 105Interchain (with heavy chain)

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    PRIDEiP0CG04.

    Expressioni

    Gene expression databases

    BgeeiP0CG04.

    Interactioni

    Protein-protein interaction databases

    IntActiP0CG04. 4 interactions.
    MINTiMINT-1504426.

    Structurei

    Secondary structure

    1
    106
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi8 – 125
    Helixi16 – 205
    Beta strandi24 – 3613
    Beta strandi39 – 446
    Beta strandi47 – 493
    Beta strandi53 – 553
    Beta strandi64 – 7411
    Helixi76 – 816
    Beta strandi85 – 917
    Beta strandi94 – 1007
    Turni102 – 1054

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1ZVOX-ray-A/B9-106[»]
    2FB4X-ray1.90L1-106[»]
    2IG2X-ray3.00L1-106[»]
    ProteinModelPortaliP0CG04.
    SMRiP0CG04. Positions 1-102.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP0CG04.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini7 – 10195Ig-likeAdd
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin C region, Immunoglobulin domain

    Phylogenomic databases

    HOVERGENiHBG039526.
    InParanoidiP01842.
    PhylomeDBiP0CG04.

    Family and domain databases

    Gene3Di2.60.40.10. 1 hit.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view]
    PfamiPF07654. C1-set. 1 hit.
    [Graphical view]
    SMARTiSM00407. IGc1. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P0CG04-1 [UniParc]FASTAAdd to Basket

    « Hide

    GQPKANPTVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADGSPVK    50
    AGVETTKPSK QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV 100
    APTECS 106
    Length:106
    Mass (Da):11,348
    Last modified:June 15, 2010 - v1
    Checksum:i4BA84D404ECA997E
    GO

    Sequence cautioni

    The sequence CAA36047.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51755 Genomic DNA. Translation: CAA36047.1. Different initiation.
    J00252 Genomic DNA. Translation: AAA59106.1.
    PIRiA92057. L2HU.
    UniGeneiHs.449585.

    Genome annotation databases

    UCSCiuc010gtu.3. human.

    Polymorphism databases

    DMDMi298351713.

    Cross-referencesi

    Web resourcesi

    IMGT/GENE-DB

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X51755 Genomic DNA. Translation: CAA36047.1 . Different initiation.
    J00252 Genomic DNA. Translation: AAA59106.1 .
    PIRi A92057. L2HU.
    UniGenei Hs.449585.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1ZVO X-ray - A/B 9-106 [» ]
    2FB4 X-ray 1.90 L 1-106 [» ]
    2IG2 X-ray 3.00 L 1-106 [» ]
    ProteinModelPortali P0CG04.
    SMRi P0CG04. Positions 1-102.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi P0CG04. 4 interactions.
    MINTi MINT-1504426.

    Protein family/group databases

    IMGTi Search...
    Search...

    Polymorphism databases

    DMDMi 298351713.

    Proteomic databases

    PRIDEi P0CG04.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    UCSCi uc010gtu.3. human.

    Organism-specific databases

    GeneCardsi GC22P023251.
    HGNCi HGNC:5855. IGLC1.
    MIMi 147220. gene.
    neXtProti NX_P0CG04.
    GenAtlasi Search...

    Phylogenomic databases

    HOVERGENi HBG039526.
    InParanoidi P01842.
    PhylomeDBi P0CG04.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
    REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
    REACT_160158. Role of phospholipids in phagocytosis.
    REACT_160163. Scavenging of heme from plasma.
    REACT_160274. FCGR activation.
    REACT_163701. FCERI mediated MAPK activation.
    REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
    REACT_163834. FCERI mediated Ca+2 mobilization.
    REACT_163936. Fc epsilon receptor (FCERI) signaling.
    REACT_163994. FCERI mediated NF-kB activation.
    REACT_7956. Classical antibody-mediated complement activation.
    REACT_8024. Initial triggering of complement.

    Miscellaneous databases

    EvolutionaryTracei P0CG04.
    PROi P0CG04.
    SOURCEi Search...

    Gene expression databases

    Bgeei P0CG04.

    Family and domain databases

    Gene3Di 2.60.40.10. 1 hit.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR003597. Ig_C1-set.
    [Graphical view ]
    Pfami PF07654. C1-set. 1 hit.
    [Graphical view ]
    SMARTi SM00407. IGc1. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 1 hit.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Primary structure of the Mcg lambda chain."
      Fett J.W., Deutsch H.F.
      Biochemistry 13:4102-4114(1974) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN MCG).
    2. "Structure and expression of the human immunoglobulin lambda genes."
      Vasicek T.J., Leder P.
      J. Exp. Med. 172:609-620(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Clustered arrangement of immunoglobulin lambda constant region genes in man."
      Hieter P.A., Hollis G.F., Korsmeyer S.J., Waldmann T.A., Leder P.
      Nature 294:536-540(1981) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-106.
    4. "Rotational allomerism and divergent evolution of domains in immunoglobulin light chains."
      Edmundson A.B., Ely K.R., Abola E.E., Schiffer M., Panagiotopoulos N.
      Biochemistry 14:3953-3961(1975)
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF MCG.
    5. "Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms."
      Ely K.R., Herron J.N., Harker M., Edmundson A.B.
      J. Mol. Biol. 210:601-615(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF MCG.
    6. "Immunoglobulin lambda (IGL) genes of human and mouse."
      Lefranc M.-P., Lefranc G.
      (In) Honjo T., Alt F.W., Neuberger M. (eds.); Molecular Biology of B Cells, pp.37-59, Elsevier Academic Press, London (2004)
      Cited for: SEROLOGICAL ISOTYPE.

    Entry informationi

    Entry nameiLAC1_HUMAN
    AccessioniPrimary (citable) accession number: P0CG04
    Secondary accession number(s): A0M8Q4, P01842, P80423
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 15, 2010
    Last sequence update: June 15, 2010
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Displays the following serological isotype: Mcg+, Kern+ and Oz-. The Mcg isotype marker is characterized by Asn-6, Thr-8 and Lys-57; the Ke marker by Gly-46 and the Oz- marker by Arg-83.

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3