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Protein

Immunoglobulin lambda constant 1

Gene

IGLC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Constant region of immunoglobulin heavy chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:22158414, PubMed:20176268). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268).3 Publications

GO - Molecular functioni

  • antigen binding Source: UniProtKB
  • immunoglobulin receptor binding Source: GO_Central
  • serine-type endopeptidase activity Source: Reactome

GO - Biological processi

Keywordsi

Molecular functionBence-Jones protein
Biological processAdaptive immunity, Immunity

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Names & Taxonomyi

Protein namesi
Recommended name:
Immunoglobulin lambda constant 12 Publications
Alternative name(s):
Ig lambda chain C region MGC1 Publication
Ig lambda-1 chain C regionCurated
Gene namesi
Name:IGLC12 Publications
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5855. IGLC1.

Subcellular locationi

GO - Cellular componenti

  • blood microparticle Source: UniProtKB
  • external side of plasma membrane Source: GO_Central
  • extracellular exosome Source: UniProtKB
  • extracellular region Source: Reactome
  • extracellular space Source: UniProtKB
  • immunoglobulin complex, circulating Source: GO_Central
  • plasma membrane Source: Reactome

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3537.

Chemistry databases

DrugBankiDB03088. Pyroglutamic Acid.

Polymorphism and mutation databases

DMDMi298351713.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000153607‹1 – 106Immunoglobulin lambda constant 1Add BLAST›106

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 87PROSITE-ProRule annotation
Disulfide bondi105Interchain (with heavy chain)

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP0CG04.
PaxDbiP0CG04.
PeptideAtlasiP0CG04.
PRIDEiP0CG04.

Expressioni

Gene expression databases

BgeeiENSG00000254709.

Interactioni

Subunit structurei

Immunoglobulins are composed of two identical heavy chains and two identical light chains; disulfide-linked.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiP0CG04. 5 interactors.
MINTiMINT-1504426.
STRINGi9606.ENSP00000431254.

Structurei

Secondary structure

1106
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 12Combined sources5
Helixi16 – 20Combined sources5
Beta strandi24 – 36Combined sources13
Beta strandi39 – 44Combined sources6
Beta strandi47 – 49Combined sources3
Beta strandi53 – 55Combined sources3
Beta strandi64 – 74Combined sources11
Helixi76 – 81Combined sources6
Beta strandi85 – 91Combined sources7
Beta strandi94 – 100Combined sources7
Turni102 – 105Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZVOX-ray-A/B9-106[»]
2FB4X-ray1.90L1-106[»]
2IG2X-ray3.00L1-106[»]
ProteinModelPortaliP0CG04.
SMRiP0CG04.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CG04.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 101Ig-likePROSITE-ProRule annotationAdd BLAST95

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

eggNOGiENOG410J0XA. Eukaryota.
ENOG410YZ00. LUCA.
HOVERGENiHBG039526.
InParanoidiP0CG04.
PhylomeDBiP0CG04.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CG04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GQPKANPTVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADGSPVK
60 70 80 90 100
AGVETTKPSK QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV

APTECS
Length:106
Mass (Da):11,348
Last modified:June 15, 2010 - v1
Checksum:i4BA84D404ECA997E
GO

Sequence cautioni

The sequence CAA36047 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei11

Polymorphismi

There are several alleles. The sequence shown is that of IMGT allele IGLC1*02.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51755 Genomic DNA. Translation: CAA36047.1. Different initiation.
AC245028 Genomic DNA. No translation available.
J00252 Genomic DNA. Translation: AAA59106.1.
PIRiA92057. L2HU.
UniGeneiHs.449585.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51755 Genomic DNA. Translation: CAA36047.1. Different initiation.
AC245028 Genomic DNA. No translation available.
J00252 Genomic DNA. Translation: AAA59106.1.
PIRiA92057. L2HU.
UniGeneiHs.449585.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZVOX-ray-A/B9-106[»]
2FB4X-ray1.90L1-106[»]
2IG2X-ray3.00L1-106[»]
ProteinModelPortaliP0CG04.
SMRiP0CG04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0CG04. 5 interactors.
MINTiMINT-1504426.
STRINGi9606.ENSP00000431254.

Chemistry databases

DrugBankiDB03088. Pyroglutamic Acid.

Polymorphism and mutation databases

DMDMi298351713.

Proteomic databases

MaxQBiP0CG04.
PaxDbiP0CG04.
PeptideAtlasiP0CG04.
PRIDEiP0CG04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

DisGeNETi3537.
GeneCardsiIGLC1.
HGNCiHGNC:5855. IGLC1.
MIMi147220. gene.
neXtProtiNX_P0CG04.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J0XA. Eukaryota.
ENOG410YZ00. LUCA.
HOVERGENiHBG039526.
InParanoidiP0CG04.
PhylomeDBiP0CG04.

Enzyme and pathway databases

ReactomeiR-HSA-166663. Initial triggering of complement.
R-HSA-173623. Classical antibody-mediated complement activation.
R-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-2029481. FCGR activation.
R-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-2029485. Role of phospholipids in phagocytosis.
R-HSA-2168880. Scavenging of heme from plasma.
R-HSA-2454202. Fc epsilon receptor (FCERI) signaling.
R-HSA-2730905. Role of LAT2/NTAL/LAB on calcium mobilization.
R-HSA-2871796. FCERI mediated MAPK activation.
R-HSA-2871809. FCERI mediated Ca+2 mobilization.
R-HSA-2871837. FCERI mediated NF-kB activation.
R-HSA-5690714. CD22 mediated BCR regulation.
R-HSA-983695. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.

Miscellaneous databases

EvolutionaryTraceiP0CG04.
PROiPR:P0CG04.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000254709.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
PfamiView protein in Pfam
PF07654. C1-set. 1 hit.
SMARTiView protein in SMART
SM00407. IGc1. 1 hit.
SUPFAMiSSF48726. SSF48726. 1 hit.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiIGLC1_HUMAN
AccessioniPrimary (citable) accession number: P0CG04
Secondary accession number(s): A0A075B6K8
, A0M8Q4, P01842, P80423
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 12, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

For an example of a full length immunoglobulin lambda light chain see AC P0DOX8.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.