P0CG04 (LAC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ig lambda-1 chain C regions

Gene names

Name:

IGLC1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	106 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Miscellaneous	Displays the following serological isotype: Mcg+, Kern+ and Oz-. The Mcg isotype marker is characterized by Asn-6, Thr-8 and Lys-57; the Ke marker by Gly-46 and the Oz- marker by Arg-83.
Sequence similarities	Contains 1 Ig-like (immunoglobulin-like) domain.
Sequence caution	The sequence CAA36047.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Domain	Immunoglobulin C region Immunoglobulin domain
Molecular function	Bence-Jones protein
PTM	Disulfide bond
Technical term	3D-structure Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	complement activation, classical pathway Traceable author statement. Source: Reactome innate immune response Traceable author statement. Source: Reactome
Cellular_component	extracellular region Traceable author statement. Source: Reactome plasma membrane Traceable author statement. Source: Reactome
Molecular_function	antigen binding Non-traceable author statement PubMed 4909564. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

‹1 – 106

›106

Ig lambda-1 chain C regions

PRO_0000153607

Regions

Domain

7 – 101

95

Ig-like

Amino acid modifications

Disulfide bond

28 ↔ 87

Disulfide bond

105

Interchain (with heavy chain)

Experimental info

Non-terminal residue

1

1

Secondary structure

1

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106

Helix Strand Turn

Details...

Beta strand

10 – 12

3

Helix

16 – 20

5

Beta strand

24 – 36

13

Beta strand

39 – 44

6

Beta strand

47 – 49

3

Beta strand

51 – 55

5

Beta strand

64 – 74

11

Helix

76 – 81

6

Beta strand

85 – 91

7

Beta strand

94 – 96

3

Turn

102 – 105

4

Sequences

	Sequence		Length	Mass (Da)
	P0CG04 [UniParc]. Last modified June 15, 2010. Version 1. Checksum: 4BA84D404ECA997E	FASTA	106	11,348
	10 20 30 40 50 60 GQPKANPTVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADGSPVK AGVETTKPSK 70 80 90 100 QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV APTECS

References

[1]	"Primary structure of the Mcg lambda chain." Fett J.W., Deutsch H.F. Biochemistry 13:4102-4114(1974) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN MCG).
[2]	"Structure and expression of the human immunoglobulin lambda genes." Vasicek T.J., Leder P. J. Exp. Med. 172:609-620(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Clustered arrangement of immunoglobulin lambda constant region genes in man." Hieter P.A., Hollis G.F., Korsmeyer S.J., Waldmann T.A., Leder P. Nature 294:536-540(1981) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-106.
[4]	"Rotational allomerism and divergent evolution of domains in immunoglobulin light chains." Edmundson A.B., Ely K.R., Abola E.E., Schiffer M., Panagiotopoulos N. Biochemistry 14:3953-3961(1975) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF MCG.
[5]	"Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms." Ely K.R., Herron J.N., Harker M., Edmundson A.B. J. Mol. Biol. 210:601-615(1989) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF MCG.
[6]	"Immunoglobulin lambda (IGL) genes of human and mouse." Lefranc M.-P., Lefranc G. (In) Honjo T., Alt F.W., Neuberger M. (eds.); Molecular Biology of B Cells, pp.37-59, Elsevier Academic Press, London (2004) Cited for: SEROLOGICAL ISOTYPE.
+	Additional computationally mapped references.

Web resources

IMGT/GENE-DB

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X51755 Genomic DNA. Translation: CAA36047.1. Different initiation.
J00252 Genomic DNA. Translation: AAA59106.1.

IPI

IPI00852577.

PIR

L2HU. A92057.

UniGene

Hs.449585.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1ZVO	X-ray	-	A/B	1-105	[»]
2IG2	X-ray	3.00	L	1-106	[»]

ProteinModelPortal

P0CG04.

SMR

P0CG04. Positions 1-102.

ModBase

Search...

Protein-protein interaction databases

IntAct

P0CG04. 4 interactions.

MINT

MINT-1504426.

Protein family/group databases

IMGT

Search...
Search...

Polymorphism databases

DMDM

298351713.

Proteomic databases

PRIDE

P0CG04.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Organism-specific databases

GeneCards

GC22P023238.

HGNC

HGNC:5855. IGLC1.

MIM

147220. gene.

neXtProt

NX_P0CG04.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

HBG039526.

InParanoid

P01842.

OrthoDB

EOG4DNF62.

Enzyme and pathway databases

Reactome

REACT_6900. Immune System.

Gene expression databases

ArrayExpress

P0CG04.

Bgee

P0CG04.

GermOnline

ENSG00000100208. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 1 hit.

InterPro

IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]

Pfam

PF07654. C1-set. 1 hit.
[Graphical view]

SMART

SM00407. IGc1. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P0CG04.

SOURCE

Search...

Entry information

Entry name

LAC1_HUMAN

Accession

Primary (citable) accession number: P0CG04
Secondary accession number(s): A0M8Q4, P01842, P80423

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 15, 2010
Last sequence update:	June 15, 2010
Last modified:	April 3, 2013
This is version 26 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.