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P0CG04 (LAC1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ig lambda-1 chain C regions
Gene names
Name:IGLC1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length106 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Miscellaneous

Displays the following serological isotype: Mcg+, Kern+ and Oz-. The Mcg isotype marker is characterized by Asn-6, Thr-8 and Lys-57; the Ke marker by Gly-46 and the Oz- marker by Arg-83.

Sequence similarities

Contains 1 Ig-like (immunoglobulin-like) domain.

Sequence caution

The sequence CAA36047.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain‹1 – 106›106Ig lambda-1 chain C regions
PRO_0000153607

Regions

Domain7 – 10195Ig-like

Amino acid modifications

Disulfide bond28 ↔ 87
Disulfide bond105Interchain (with heavy chain)

Experimental info

Non-terminal residue11

Secondary structure

....................... 106
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P0CG04 [UniParc].

Last modified June 15, 2010. Version 1.
Checksum: 4BA84D404ECA997E

FASTA10611,348
        10         20         30         40         50         60 
GQPKANPTVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADGSPVK AGVETTKPSK 

        70         80         90        100 
QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV APTECS 

« Hide

References

[1]"Primary structure of the Mcg lambda chain."
Fett J.W., Deutsch H.F.
Biochemistry 13:4102-4114(1974) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN MCG).
[2]"Structure and expression of the human immunoglobulin lambda genes."
Vasicek T.J., Leder P.
J. Exp. Med. 172:609-620(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Clustered arrangement of immunoglobulin lambda constant region genes in man."
Hieter P.A., Hollis G.F., Korsmeyer S.J., Waldmann T.A., Leder P.
Nature 294:536-540(1981) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-106.
[4]"Rotational allomerism and divergent evolution of domains in immunoglobulin light chains."
Edmundson A.B., Ely K.R., Abola E.E., Schiffer M., Panagiotopoulos N.
Biochemistry 14:3953-3961(1975)
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF MCG.
[5]"Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms."
Ely K.R., Herron J.N., Harker M., Edmundson A.B.
J. Mol. Biol. 210:601-615(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF MCG.
[6]"Immunoglobulin lambda (IGL) genes of human and mouse."
Lefranc M.-P., Lefranc G.
(In) Honjo T., Alt F.W., Neuberger M. (eds.); Molecular Biology of B Cells, pp.37-59, Elsevier Academic Press, London (2004)
Cited for: SEROLOGICAL ISOTYPE.
+Additional computationally mapped references.

Web resources

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X51755 Genomic DNA. Translation: CAA36047.1. Different initiation.
J00252 Genomic DNA. Translation: AAA59106.1.
PIRL2HU. A92057.
UniGeneHs.449585.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZVOX-ray-A/B1-105[»]
2IG2X-ray3.00L1-106[»]
ProteinModelPortalP0CG04.
SMRP0CG04. Positions 1-102.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActP0CG04. 4 interactions.
MINTMINT-1504426.

Protein family/group databases

IMGTSearch...
Search...

Polymorphism databases

DMDM298351713.

Proteomic databases

PRIDEP0CG04.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

UCSCuc010gtu.3. human.

Organism-specific databases

GeneCardsGC22P023251.
HGNCHGNC:5855. IGLC1.
MIM147220. gene.
neXtProtNX_P0CG04.
GenAtlasSearch...

Phylogenomic databases

HOVERGENHBG039526.
InParanoidP01842.
PhylomeDBP0CG04.

Enzyme and pathway databases

ReactomeREACT_160300. Binding and Uptake of Ligands by Scavenger Receptors.
REACT_6900. Immune System.

Gene expression databases

BgeeP0CG04.

Family and domain databases

Gene3D2.60.40.10. 1 hit.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamPF07654. C1-set. 1 hit.
[Graphical view]
SMARTSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP0CG04.
PROP0CG04.
SOURCESearch...

Entry information

Entry nameLAC1_HUMAN
AccessionPrimary (citable) accession number: P0CG04
Secondary accession number(s): A0M8Q4, P01842, P80423
Entry history
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: April 16, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 22

Human chromosome 22: entries, gene names and cross-references to MIM