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Protein

Ig lambda-1 chain C regions

Gene

IGLC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. antigen binding Source: UniProtKB

GO - Biological processi

  1. complement activation Source: Reactome
  2. complement activation, classical pathway Source: Reactome
  3. Fc-epsilon receptor signaling pathway Source: Reactome
  4. Fc-gamma receptor signaling pathway involved in phagocytosis Source: Reactome
  5. immune response Source: UniProtKB
  6. innate immune response Source: Reactome
  7. receptor-mediated endocytosis Source: Reactome
  8. regulation of immune response Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Bence-Jones protein

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160163. Scavenging of heme from plasma.
REACT_160274. FCGR activation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Names & Taxonomyi

Protein namesi
Recommended name:
Ig lambda-1 chain C regions
Gene namesi
Name:IGLC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:5855. IGLC1.

Subcellular locationi

GO - Cellular componenti

  1. blood microparticle Source: UniProtKB
  2. extracellular region Source: Reactome
  3. extracellular space Source: UniProtKB
  4. extracellular vesicular exosome Source: UniProtKB
  5. plasma membrane Source: Reactome
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini‹1 – 106›106Ig lambda-1 chain C regionsPRO_0000153607Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi28 ↔ 87
Disulfide bondi105 – 105Interchain (with heavy chain)

Keywords - PTMi

Disulfide bond

Proteomic databases

PRIDEiP0CG04.

Expressioni

Gene expression databases

BgeeiP0CG04.
ExpressionAtlasiP0CG04. baseline.

Interactioni

Protein-protein interaction databases

IntActiP0CG04. 4 interactions.
MINTiMINT-1504426.

Structurei

Secondary structure

1
106
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 125Combined sources
Helixi16 – 205Combined sources
Beta strandi24 – 3613Combined sources
Beta strandi39 – 446Combined sources
Beta strandi47 – 493Combined sources
Beta strandi53 – 553Combined sources
Beta strandi64 – 7411Combined sources
Helixi76 – 816Combined sources
Beta strandi85 – 917Combined sources
Beta strandi94 – 1007Combined sources
Turni102 – 1054Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZVOX-ray-A/B9-106[»]
2FB4X-ray1.90L1-106[»]
2IG2X-ray3.00L1-106[»]
ProteinModelPortaliP0CG04.
SMRiP0CG04. Positions 1-102.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CG04.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 10195Ig-likeAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin C region, Immunoglobulin domain

Phylogenomic databases

HOVERGENiHBG039526.
InParanoidiP0CG04.
PhylomeDBiP0CG04.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CG04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
GQPKANPTVT LFPPSSEELQ ANKATLVCLI SDFYPGAVTV AWKADGSPVK
60 70 80 90 100
AGVETTKPSK QSNNKYAASS YLSLTPEQWK SHRSYSCQVT HEGSTVEKTV

APTECS
Length:106
Mass (Da):11,348
Last modified:June 15, 2010 - v1
Checksum:i4BA84D404ECA997E
GO

Sequence cautioni

The sequence CAA36047.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51755 Genomic DNA. Translation: CAA36047.1. Different initiation.
J00252 Genomic DNA. Translation: AAA59106.1.
PIRiA92057. L2HU.
UniGeneiHs.449585.

Genome annotation databases

UCSCiuc010gtu.3. human.

Polymorphism databases

DMDMi298351713.

Cross-referencesi

Web resourcesi

IMGT/GENE-DB

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X51755 Genomic DNA. Translation: CAA36047.1. Different initiation.
J00252 Genomic DNA. Translation: AAA59106.1.
PIRiA92057. L2HU.
UniGeneiHs.449585.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ZVOX-ray-A/B9-106[»]
2FB4X-ray1.90L1-106[»]
2IG2X-ray3.00L1-106[»]
ProteinModelPortaliP0CG04.
SMRiP0CG04. Positions 1-102.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP0CG04. 4 interactions.
MINTiMINT-1504426.

Protein family/group databases

IMGTiSearch...
Search...

Polymorphism databases

DMDMi298351713.

Proteomic databases

PRIDEiP0CG04.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiuc010gtu.3. human.

Organism-specific databases

GeneCardsiGC22P023314.
HGNCiHGNC:5855. IGLC1.
MIMi147220. gene.
neXtProtiNX_P0CG04.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG039526.
InParanoidiP0CG04.
PhylomeDBiP0CG04.

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_118700. Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.
REACT_160086. Regulation of actin dynamics for phagocytic cup formation.
REACT_160158. Role of phospholipids in phagocytosis.
REACT_160163. Scavenging of heme from plasma.
REACT_160274. FCGR activation.
REACT_163701. FCERI mediated MAPK activation.
REACT_163769. Role of LAT2/NTAL/LAB on calcium mobilization.
REACT_163834. FCERI mediated Ca+2 mobilization.
REACT_163936. Fc epsilon receptor (FCERI) signaling.
REACT_163994. FCERI mediated NF-kB activation.
REACT_7956. Classical antibody-mediated complement activation.
REACT_8024. Initial triggering of complement.

Miscellaneous databases

EvolutionaryTraceiP0CG04.
PROiP0CG04.
SOURCEiSearch...

Gene expression databases

BgeeiP0CG04.
ExpressionAtlasiP0CG04. baseline.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR003597. Ig_C1-set.
[Graphical view]
PfamiPF07654. C1-set. 1 hit.
[Graphical view]
SMARTiSM00407. IGc1. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 1 hit.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure of the Mcg lambda chain."
    Fett J.W., Deutsch H.F.
    Biochemistry 13:4102-4114(1973) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE (BENCE-JONES PROTEIN MCG).
  2. "Structure and expression of the human immunoglobulin lambda genes."
    Vasicek T.J., Leder P.
    J. Exp. Med. 172:609-620(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Clustered arrangement of immunoglobulin lambda constant region genes in man."
    Hieter P.A., Hollis G.F., Korsmeyer S.J., Waldmann T.A., Leder P.
    Nature 294:536-540(1980) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 3-106.
  4. "Rotational allomerism and divergent evolution of domains in immunoglobulin light chains."
    Edmundson A.B., Ely K.R., Abola E.E., Schiffer M., Panagiotopoulos N.
    Biochemistry 14:3953-3961(1974)
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF MCG.
  5. "Three-dimensional structure of a light chain dimer crystallized in water. Conformational flexibility of a molecule in two crystal forms."
    Ely K.R., Herron J.N., Harker M., Edmundson A.B.
    J. Mol. Biol. 210:601-615(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF MCG.
  6. "Immunoglobulin lambda (IGL) genes of human and mouse."
    Lefranc M.-P., Lefranc G.
    (In) Honjo T., Alt F.W., Neuberger M. (eds.); Molecular Biology of B Cells, pp.37-59, Elsevier Academic Press, London (2003)
    Cited for: SEROLOGICAL ISOTYPE.

Entry informationi

Entry nameiLAC1_HUMAN
AccessioniPrimary (citable) accession number: P0CG04
Secondary accession number(s): A0M8Q4, P01842, P80423
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 15, 2010
Last sequence update: June 15, 2010
Last modified: March 4, 2015
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Displays the following serological isotype: Mcg+, Kern+ and Oz-. The Mcg isotype marker is characterized by Asn-6, Thr-8 and Lys-57; the Ke marker by Gly-46 and the Oz- marker by Arg-83.

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.