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Protein

Endogenous Bornavirus-like nucleoprotein 1

Gene

EBLN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May act as an RNA-binding protein. Highly homologous to the bornavirus nucleocapsid N protein that binds viral RNA and oligomerizes (By similarity).By similarity

Miscellaneous

Bornavirus is a non-retroviral RNA virus that does not generate DNA forms during viral replication. Therefore, integration of EBLN-1 must have occur through a mechanism relying on an endogenous reverse transcriptase activity.

Names & Taxonomyi

Protein namesi
Recommended name:
Endogenous Bornavirus-like nucleoprotein 1
Alternative name(s):
Endogenous Borna-like N element-1
Short name:
EBLN-1
Gene namesi
Name:EBLN1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000223601.2.
HGNCiHGNC:39430. EBLN1.

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000223601.

Polymorphism and mutation databases

DMDMi296537812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003939111 – 366Endogenous Bornavirus-like nucleoprotein 1Add BLAST366

Proteomic databases

EPDiP0CF75.
PRIDEiP0CF75.

PTM databases

iPTMnetiP0CF75.
PhosphoSitePlusiP0CF75.

Expressioni

Tissue specificityi

Expression detected by RT-PCR in a few cell lines, including OL, HEK293T and MOLT-4. Not observed in HeLa cells (PubMed:20054395).1 Publication

Gene expression databases

BgeeiENSG00000223601.

Structurei

3D structure databases

ProteinModelPortaliP0CF75.
SMRiP0CF75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00490000044176.
InParanoidiP0CF75.
OMAiANYWAKR.
OrthoDBiEOG091G08P6.

Family and domain databases

Gene3Di1.10.3040.10. 1 hit.
InterProiView protein in InterPro
IPR009441. P40_nucleoprot_BD-vir.
IPR036260. P40_nucleoprot_sf_BD-vir.
IPR015969. P40_nucleoprot_sub1_BD-vir.
PfamiView protein in Pfam
PF06407. BDV_P40. 1 hit.
SUPFAMiSSF101399. SSF101399. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CF75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRPRNNPQT SSPQDSTKDG SSFHYFQGRF ELSGKSRQYP ADALEPQPGI
60 70 80 90 100
GDVKVIEKAT KSMLDPAQRS HFYLVTPSLV FLCFIFDGLH KALLSVGVSK
110 120 130 140 150
RSNIVIGNEN KETGTLYASK FEDVLPTFTA LEMSSILRHC CDLIGIAAGS
160 170 180 190 200
SDPICTNSLQ VQRQFKAMMI SIGRPLHSES ADLLISYNAG PAIDWINSRP
210 220 230 240 250
WVGGLMFTFL FGEFESPACE LLDQVKVVAS KAQMMTYYTV RMFLDQCVDG
260 270 280 290 300
STALPAVVLE IPVFEQKKPL AKKVLGDFFE FGGVLRHPVI GVLSPQMFPN
310 320 330 340 350
LATAANYWAK RRNSTFSGFE ALDIIPGSTI TFPVLQMASA QKISRGSDMD
360
PYTLNILRGY GISGFE
Length:366
Mass (Da):40,313
Last modified:March 19, 2014 - v2
Checksum:iDA7E68FDB877E53A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti149G → R in EAW86159 (Ref. 2) Curated1
Sequence conflicti235M → T in EAW86159 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL157831 Genomic DNA. No translation available.
CH471072 Genomic DNA. Translation: EAW86159.1.
CCDSiCCDS60498.1.
RefSeqiNP_001186867.1. NM_001199938.1.
UniGeneiHs.450519.

Genome annotation databases

EnsembliENST00000422359; ENSP00000473842; ENSG00000223601.
GeneIDi340900.
KEGGihsa:340900.
UCSCiuc021pob.2. human.

Similar proteinsi

Entry informationi

Entry nameiEBLN1_HUMAN
AccessioniPrimary (citable) accession number: P0CF75
Secondary accession number(s): S4R316
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: March 19, 2014
Last modified: October 25, 2017
This is version 46 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot