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Protein

Truncated formate dehydrogenase 2

Gene

FDH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein uncertaini

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei57NADBy similarity1
Binding sitei130NAD; via carbonyl oxygenBy similarity1
Sitei132Important for catalytic activityBy similarity1
Binding sitei156NADBy similarity1
Sitei185Important for catalytic activityBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 37NADBy similarity2
Nucleotide bindingi104 – 108NADBy similarity5
Nucleotide bindingi185 – 188NADBy similarity4

GO - Molecular functioni

  • formate dehydrogenase (NAD+) activity Source: SGD
  • NAD binding Source: InterPro

GO - Biological processi

  • formate catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Truncated formate dehydrogenase 2Curated
Alternative name(s):
NAD-dependent formate dehydrogenase 21 Publication
Gene namesi
Name:FDH21 Publication
Ordered Locus Names:YPL275WImported
ORF Names:P0326
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

SGDiS000006196. FDH2.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002236481 – 236Truncated formate dehydrogenase 2Add BLAST236

Structurei

3D structure databases

ProteinModelPortaliP0CF35.
SMRiP0CF35.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP0CF35.
OrthoDBiEOG092C46U5.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CF35-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVVINKQLMV SGILPAWLKN EYDLEDKIIS TVGAGRIGYR VLERLVAFNP
60 70 80 90 100
KKLLYYDYQE LPAEAINRLN EASKLFNGRG DIVQRVEKLE DMVAQSDVVT
110 120 130 140 150
INCPLHKDSR GLFNKKLISH MKDGAYLVNT ARGAICVAED VAEAVKSGKL
160 170 180 190 200
AGYGGDVWDK QPAPKDHPWR TMDNKDHVGN AMTVHISGTS LHAQKRYAQG
210 220 230
VKNILNSYFS KKFDYRPQDI IVQNGSYATR AYGQKK
Length:236
Mass (Da):26,487
Last modified:April 20, 2010 - v1
Checksum:i1C8E40684606D166
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73632 Genomic DNA. Translation: CAA98013.1.
BK006949 Genomic DNA. No translation available.
PIRiS65308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73632 Genomic DNA. Translation: CAA98013.1.
BK006949 Genomic DNA. No translation available.
PIRiS65308.

3D structure databases

ProteinModelPortaliP0CF35.
SMRiP0CF35.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

SGDiS000006196. FDH2.

Phylogenomic databases

InParanoidiP0CF35.
OrthoDBiEOG092C46U5.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFDH2_YEAST
AccessioniPrimary (citable) accession number: P0CF35
Secondary accession number(s): Q08987, Q08988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: November 2, 2016
This is version 43 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. This is the C-terminal part of a second copy of formate dehydrogenase in the yeast genome. Strains BY4741, S288c and W303 have a stop codon in position 146, which disrupts the gene coding for this protein and produces two ORFs YPL275W and YPL276W. A contiguous sequence for formate dehydrogenase 2 can be found in strain CEN.PK113-7D (AC P0CT22).1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.