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P0CF35

- FDH2_YEAST

UniProt

P0CF35 - FDH2_YEAST

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Protein

Putative formate dehydrogenase 2

Gene

FDH2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein uncertaini

Functioni

Catalytic activityi

Formate + NAD+ = CO2 + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei132 – 1321By similarity
Binding sitei156 – 1561NADBy similarity
Active sitei185 – 1851Proton donorBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi36 – 372NADBy similarity
Nucleotide bindingi130 – 1323NADBy similarity
Nucleotide bindingi185 – 1884NADBy similarity

GO - Molecular functioni

  1. formate dehydrogenase (NAD+) activity Source: SGD
  2. NAD binding Source: InterPro

GO - Biological processi

  1. formate catabolic process Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Putative formate dehydrogenase 2 (EC:1.2.1.2)
Alternative name(s):
NAD-dependent formate dehydrogenase 2
Gene namesi
Name:FDH2
Ordered Locus Names:YPL275W
ORF Names:P0326
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome XVI

Organism-specific databases

SGDiS000006196. FDH2.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 236236Putative formate dehydrogenase 2PRO_0000223648Add
BLAST

Expressioni

Inductioni

Induced by formate.

Gene expression databases

GenevestigatoriQ08987.

Structurei

3D structure databases

ProteinModelPortaliP0CF35.
SMRiP0CF35. Positions 3-227.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

InParanoidiP0CF35.
OrthoDBiEOG7MKWHQ.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view]
PROSITEiPS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CF35-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVVINKQLMV SGILPAWLKN EYDLEDKIIS TVGAGRIGYR VLERLVAFNP
60 70 80 90 100
KKLLYYDYQE LPAEAINRLN EASKLFNGRG DIVQRVEKLE DMVAQSDVVT
110 120 130 140 150
INCPLHKDSR GLFNKKLISH MKDGAYLVNT ARGAICVAED VAEAVKSGKL
160 170 180 190 200
AGYGGDVWDK QPAPKDHPWR TMDNKDHVGN AMTVHISGTS LHAQKRYAQG
210 220 230
VKNILNSYFS KKFDYRPQDI IVQNGSYATR AYGQKK
Length:236
Mass (Da):26,487
Last modified:April 20, 2010 - v1
Checksum:i1C8E40684606D166
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73632 Genomic DNA. Translation: CAA98013.1.
BK006949 Genomic DNA. No translation available.
PIRiS65308.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z73632 Genomic DNA. Translation: CAA98013.1 .
BK006949 Genomic DNA. No translation available.
PIRi S65308.

3D structure databases

ProteinModelPortali P0CF35.
SMRi P0CF35. Positions 3-227.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

SGDi S000006196. FDH2.

Phylogenomic databases

InParanoidi P0CF35.
OrthoDBi EOG7MKWHQ.

Gene expression databases

Genevestigatori Q08987.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR029753. D-isomer_DH_CS.
IPR006140. D-isomer_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF02826. 2-Hacid_dh_C. 1 hit.
[Graphical view ]
PROSITEi PS00670. D_2_HYDROXYACID_DH_2. 1 hit.
PS00671. D_2_HYDROXYACID_DH_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence of Saccharomyces cerevisiae chromosome XVI."
    Bussey H., Storms R.K., Ahmed A., Albermann K., Allen E., Ansorge W., Araujo R., Aparicio A., Barrell B.G., Badcock K., Benes V., Botstein D., Bowman S., Brueckner M., Carpenter J., Cherry J.M., Chung E., Churcher C.M.
    , Coster F., Davis K., Davis R.W., Dietrich F.S., Delius H., DiPaolo T., Dubois E., Duesterhoeft A., Duncan M., Floeth M., Fortin N., Friesen J.D., Fritz C., Goffeau A., Hall J., Hebling U., Heumann K., Hilbert H., Hillier L.W., Hunicke-Smith S., Hyman R.W., Johnston M., Kalman S., Kleine K., Komp C., Kurdi O., Lashkari D., Lew H., Lin A., Lin D., Louis E.J., Marathe R., Messenguy F., Mewes H.-W., Mirtipati S., Moestl D., Mueller-Auer S., Namath A., Nentwich U., Oefner P., Pearson D., Petel F.X., Pohl T.M., Purnelle B., Rajandream M.A., Rechmann S., Rieger M., Riles L., Roberts D., Schaefer M., Scharfe M., Scherens B., Schramm S., Schroeder M., Sdicu A.-M., Tettelin H., Urrestarazu L.A., Ushinsky S., Vierendeels F., Vissers S., Voss H., Walsh S.V., Wambutt R., Wang Y., Wedler E., Wedler H., Winnett E., Zhong W.-W., Zollner A., Vo D.H., Hani J.
    Nature 387:103-105(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  2. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  3. "Functional analysis of structural genes for NAD(+)-dependent formate dehydrogenase in Saccharomyces cerevisiae."
    Overkamp K.M., Koetter P., van der Hoek R., Schoondermark-Stolk S., Luttik M.A.H., van Dijken J.P., Pronk J.T.
    Yeast 19:509-520(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-64, CONFIRMATION OF STOP CODON.
    Strain: ATCC 200060 / W303 and ATCC 201388 / BY4741.

Entry informationi

Entry nameiFDH2_YEAST
AccessioniPrimary (citable) accession number: P0CF35
Secondary accession number(s): Q08987, Q08988
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

Could be the product of a pseudogene. This is the C-terminal part of a second copy of formate dehydrogenase in the yeast genome. Strains BY4741, S288c and W303 have a stop codon in position 146, which disrupts the gene coding for this protein and produces two ORFs YPL275W and YPL276W. A contiguous sequence for formate dehydrogenase 2 can be found in strain CEN.PK113-7D (AC P0CT22).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XVI
    Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names

External Data

Dasty 3