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Protein

Guanine nucleotide exchange factor SDC25

Gene

SDC25

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed-Annotation score: -Protein predictedi

Functioni

Promotes the exchange of Ras-bound GDP by GTP.3 Publications

Miscellaneous

Suppresses the CDC25-5 mutation in yeast (restores cAMP level) and has similar functions as CDC25.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor SDC25
Gene namesi
Name:SDC25
Synonyms:SCD25
OrganismiSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688931 – 1253Guanine nucleotide exchange factor SDC25Add BLAST1253

Proteomic databases

PRIDEiP0CF32

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP0CF32, 4 interactors
MINTiP0CF32

Structurei

3D structure databases

ProteinModelPortaliP0CF32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 98SH3PROSITE-ProRule annotationAdd BLAST73
Domaini782 – 914N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST133
Domaini952 – 1199Ras-GEFPROSITE-ProRule annotationAdd BLAST248

Keywords - Domaini

SH3 domain

Family and domain databases

CDDicd00155 RasGEF, 1 hit
cd06224 REM, 1 hit
Gene3Di1.10.840.10, 2 hits
InterProiView protein in InterPro
IPR000651 Ras-like_Gua-exchang_fac_N
IPR019804 Ras_G-nucl-exch_fac_CS
IPR023578 Ras_GEF_dom_sf
IPR001895 RASGEF_cat_dom
IPR036964 RASGEF_cat_dom_sf
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
PfamiView protein in Pfam
PF00617 RasGEF, 1 hit
PF00618 RasGEF_N, 1 hit
PF00018 SH3_1, 1 hit
SMARTiView protein in SMART
SM00147 RasGEF, 1 hit
SM00229 RasGEFN, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF48366 SSF48366, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS00720 RASGEF, 1 hit
PS50009 RASGEF_CAT, 1 hit
PS50212 RASGEF_NTER, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

P0CF32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCTASYAGM TTPVKDKEGH GIPCLQPIDV VECTYQYFTK SRNKLSLRVG
60 70 80 90 100
DLIYVLTKGS NGWWDGVLIR HSANNNNNNS LILDRGWFPP SFTRSILNEL
110 120 130 140 150
HGVPDIGNEL EIFQAGLNLK LELSSNPVIL SLEDFLDCCR DIEFKEQLAW
160 170 180 190 200
SPTPVHERKG CCELLYYNQD LDVYCRTLPY LPQNQVETVN DYSSFPAISK
210 220 230 240 250
IAGKKMPITS SPDLFYLNDC DVVYWYDLTR LVCHYVNLTE RDLLANEREK
260 270 280 290 300
FLTSLDLLTA QITYVYMLFR NLRLVEDSFK KTLKKLIYTL SRFSINANIW
310 320 330 340 350
FHSTSFEERE AIASQKDPER RSPLLQSILG TFQKFHFLLR LLHFLSNPNE
360 370 380 390 400
LTILPQLTPR FFKDSFNTIS WNNPFLRTVF NQHMSMTLPR QMIKAVAGAS
410 420 430 440 450
GIVAENIDEI PASKQGTFIS SETSHHSPSA PFQRRRRGTI FSNVSGSSDE
460 470 480 490 500
SDTIWSKRKK PYPLNEETLS LVRARKKQLD GKLKQMIKSA NEYLSNTANF
510 520 530 540 550
SKMLNFEMNF KTYEEVSGTI PIIDILENLD LTIFLNLREL GDENRVFDED
560 570 580 590 600
VAIGDEDKEF LKHSLSSLSY ILSDYFNMKQ YFHDVVVKFI IVAQHLTLED
610 620 630 640 650
PFVFSPMQND LPTGYYEPMK PSSLNLDNAK DKKNGSQNTD IQEEEDEYEP
660 670 680 690 700
DPDSLILFHN LINQDSDFND LKFFNLAHVF KKSCDDYFDV LKLAIEFVNQ
710 720 730 740 750
LILERENLLN YAARMMKNNI TELLLRGEEG YGSYDGGETA EKSDTNAVYA
760 770 780 790 800
DSDTKDNDEW RDSQVKLPRY LQREYDSELI WGPIVRIKGG SKHALISYLT
810 820 830 840 850
DNEKKDLFFN ITFLITFRSI FTTTEFLSYL ISQYNLDPPE DLCFEEYNEW
860 870 880 890 900
VTKKLIPVKC RVVEIMTTFF KQYWFPGYDE PDLATLNLDY FAQVAIKENI
910 920 930 940 950
TGSVELLKEV NQKFKLGNIQ EATAPMKTLD QQICQDHYSG TLYSTTESIL
960 970 980 990 1000
AVDPVLFATQ LTILEHEIYC EITIFDCLQK IWKNKYTKSY GASPGLNEFI
1010 1020 1030 1040 1050
SFANKLTNFI SYSVVKEADK SKRAKLLSHF IFIAEYCRKF NNFSSMTAII
1060 1070 1080 1090 1100
SALYSSPIYR LEKTWQAVIP QTRDLLQSLN KLMDPKKNFI NYRNELKSLH
1110 1120 1130 1140 1150
SAPCVPFFGV YLSDLTFTDS GNPDYLVLEH GLKGVHDEKK YINFNKRSRL
1160 1170 1180 1190 1200
VDILQEIIYF KKTHYDFTKD RTVIECISNS LENIPHIEKQ YQLSLIIEPK
1210 1220 1230 1240 1250
PRKKVVPNSN SNNKSQEKSR DDQTDEGKTS TKKDRFPKFQ LHKTKKKAPK

VSK
Length:1,253
Mass (Da):144,980
Last modified:April 20, 2010 - v1
Checksum:i2DE2C9EC27E3E60D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti682 – 692KSCDDYFDVLK → NPVMTILMCLN in strain: 0L136. Add BLAST11
Natural varianti740Missing in strain: 0L136. 1
Natural varianti783 – 785PIV → SNN in strain: 0L136. 3
Natural varianti974I → T in strain: 0L136. 1
Natural varianti1048A → D in strain: 0L136. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26647 Genomic DNA Translation: AAA16565.1
PIRiS14177

Similar proteinsi

Entry informationi

Entry nameiSDC25_YEASX
AccessioniPrimary (citable) accession number: P0CF32
Secondary accession number(s): P14771
, Q12037, Q12065, Q6B0T5, Q6WV04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

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