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Protein

Guanine nucleotide exchange factor SDC25

Gene

SDC25

Organism
Saccharomyces cerevisiae (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein predictedi

Functioni

Promotes the exchange of Ras-bound GDP by GTP.3 Publications

Miscellaneous

Suppresses the CDC25-5 mutation in yeast (restores cAMP level) and has similar functions as CDC25.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGuanine-nucleotide releasing factor
Biological processCell cycle, Cell division

Names & Taxonomyi

Protein namesi
Recommended name:
Guanine nucleotide exchange factor SDC25
Gene namesi
Name:SDC25
Synonyms:SCD25
OrganismiSaccharomyces cerevisiae (Baker's yeast)
Taxonomic identifieri4932 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000688931 – 1253Guanine nucleotide exchange factor SDC25Add BLAST1253

Interactioni

Protein-protein interaction databases

IntActiP0CF32. 4 interactors.

Structurei

3D structure databases

ProteinModelPortaliP0CF32.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 97SH3PROSITE-ProRule annotationAdd BLAST72
Domaini782 – 914N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST133
Domaini952 – 1199Ras-GEFPROSITE-ProRule annotationAdd BLAST248

Keywords - Domaini

SH3 domain

Family and domain databases

CDDicd00155. RasGEF. 1 hit.
cd06224. REM. 1 hit.
Gene3Di1.10.840.10. 1 hit.
InterProiView protein in InterPro
IPR000651. Ras-like_Gua-exchang_fac_N.
IPR019804. Ras_G-nucl-exch_fac_CS.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR001452. SH3_domain.
PfamiView protein in Pfam
PF00617. RasGEF. 1 hit.
PF00618. RasGEF_N. 1 hit.
PF00018. SH3_1. 1 hit.
SMARTiView protein in SMART
SM00147. RasGEF. 1 hit.
SM00229. RasGEFN. 1 hit.
SM00326. SH3. 1 hit.
SUPFAMiSSF48366. SSF48366. 1 hit.
SSF50044. SSF50044. 1 hit.
PROSITEiView protein in PROSITE
PS00720. RASGEF. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
PS50212. RASGEF_NTER. 1 hit.
PS50002. SH3. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CF32-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSCTASYAGM TTPVKDKEGH GIPCLQPIDV VECTYQYFTK SRNKLSLRVG
60 70 80 90 100
DLIYVLTKGS NGWWDGVLIR HSANNNNNNS LILDRGWFPP SFTRSILNEL
110 120 130 140 150
HGVPDIGNEL EIFQAGLNLK LELSSNPVIL SLEDFLDCCR DIEFKEQLAW
160 170 180 190 200
SPTPVHERKG CCELLYYNQD LDVYCRTLPY LPQNQVETVN DYSSFPAISK
210 220 230 240 250
IAGKKMPITS SPDLFYLNDC DVVYWYDLTR LVCHYVNLTE RDLLANEREK
260 270 280 290 300
FLTSLDLLTA QITYVYMLFR NLRLVEDSFK KTLKKLIYTL SRFSINANIW
310 320 330 340 350
FHSTSFEERE AIASQKDPER RSPLLQSILG TFQKFHFLLR LLHFLSNPNE
360 370 380 390 400
LTILPQLTPR FFKDSFNTIS WNNPFLRTVF NQHMSMTLPR QMIKAVAGAS
410 420 430 440 450
GIVAENIDEI PASKQGTFIS SETSHHSPSA PFQRRRRGTI FSNVSGSSDE
460 470 480 490 500
SDTIWSKRKK PYPLNEETLS LVRARKKQLD GKLKQMIKSA NEYLSNTANF
510 520 530 540 550
SKMLNFEMNF KTYEEVSGTI PIIDILENLD LTIFLNLREL GDENRVFDED
560 570 580 590 600
VAIGDEDKEF LKHSLSSLSY ILSDYFNMKQ YFHDVVVKFI IVAQHLTLED
610 620 630 640 650
PFVFSPMQND LPTGYYEPMK PSSLNLDNAK DKKNGSQNTD IQEEEDEYEP
660 670 680 690 700
DPDSLILFHN LINQDSDFND LKFFNLAHVF KKSCDDYFDV LKLAIEFVNQ
710 720 730 740 750
LILERENLLN YAARMMKNNI TELLLRGEEG YGSYDGGETA EKSDTNAVYA
760 770 780 790 800
DSDTKDNDEW RDSQVKLPRY LQREYDSELI WGPIVRIKGG SKHALISYLT
810 820 830 840 850
DNEKKDLFFN ITFLITFRSI FTTTEFLSYL ISQYNLDPPE DLCFEEYNEW
860 870 880 890 900
VTKKLIPVKC RVVEIMTTFF KQYWFPGYDE PDLATLNLDY FAQVAIKENI
910 920 930 940 950
TGSVELLKEV NQKFKLGNIQ EATAPMKTLD QQICQDHYSG TLYSTTESIL
960 970 980 990 1000
AVDPVLFATQ LTILEHEIYC EITIFDCLQK IWKNKYTKSY GASPGLNEFI
1010 1020 1030 1040 1050
SFANKLTNFI SYSVVKEADK SKRAKLLSHF IFIAEYCRKF NNFSSMTAII
1060 1070 1080 1090 1100
SALYSSPIYR LEKTWQAVIP QTRDLLQSLN KLMDPKKNFI NYRNELKSLH
1110 1120 1130 1140 1150
SAPCVPFFGV YLSDLTFTDS GNPDYLVLEH GLKGVHDEKK YINFNKRSRL
1160 1170 1180 1190 1200
VDILQEIIYF KKTHYDFTKD RTVIECISNS LENIPHIEKQ YQLSLIIEPK
1210 1220 1230 1240 1250
PRKKVVPNSN SNNKSQEKSR DDQTDEGKTS TKKDRFPKFQ LHKTKKKAPK

VSK
Length:1,253
Mass (Da):144,980
Last modified:April 20, 2010 - v1
Checksum:i2DE2C9EC27E3E60D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti682 – 692KSCDDYFDVLK → NPVMTILMCLN in strain: 0L136. Add BLAST11
Natural varianti740Missing in strain: 0L136. 1
Natural varianti783 – 785PIV → SNN in strain: 0L136. 3
Natural varianti974I → T in strain: 0L136. 1
Natural varianti1048A → D in strain: 0L136. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26647 Genomic DNA. Translation: AAA16565.1.
PIRiS14177.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSDC25_YEASX
AccessioniPrimary (citable) accession number: P0CF32
Secondary accession number(s): P14771
, Q12037, Q12065, Q6B0T5, Q6WV04
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: February 15, 2017
This is version 33 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program