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Protein

Forkhead box protein P2

Gene

Foxp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Protein inferred from homologyi

Functioni

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays a role in synapse formation by regulating SRPX2 levels.By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri343 – 366C2H2-typeAdd BLAST24
DNA bindingi499 – 589Fork-headPROSITE-ProRule annotationAdd BLAST91

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P2
Gene namesi
Name:Foxp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1559697. Foxp2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003934011 – 710Forkhead box protein P2Add BLAST710

Proteomic databases

PaxDbiP0CF24.

Expressioni

Gene expression databases

BgeeiENSRNOG00000054508.
GenevisibleiP0CF24. RN.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Interacts with FOXP1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007759.

Structurei

3D structure databases

SMRiP0CF24.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni383 – 404Leucine-zipperAdd BLAST22
Regioni417 – 421CTBP1-bindingBy similarity5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi53 – 263Gln-richAdd BLAST211

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri343 – 366C2H2-typeAdd BLAST24

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
InParanoidiP0CF24.
KOiK09409.
OMAiETKLCVC.
OrthoDBiEOG091G08HY.
PhylomeDBiP0CF24.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
2.130.10.10. 1 hit.
InterProiView protein in InterPro
IPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR011991. WHTH_DNA-bd_dom.
PfamiView protein in Pfam
PF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
PRINTSiPR00053. FORKHEAD.
SMARTiView protein in SMART
SM00339. FH. 1 hit.
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiView protein in PROSITE
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CF24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL
60 70 80 90 100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT
110 120 130 140 150
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL
160 170 180 190 200
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQHPG KQAKEQQQQQ
210 220 230 240 250
QQQQLAAQQL VFQQQLLQMQ QLQQQQHLLS LQCQGLISIP PGQAALPVQS
260 270 280 290 300
LPQAGLSPAE IQQLWKEVTG VHSQEDNGIK HGGLDLTTNN SSSTTSSTTS
310 320 330 340 350
KASPPITHHS IVNGQSSVLN ARRDSSSHEE TGASHTLYGH GVCKWPGCES
360 370 380 390 400
ICEDFGQFLK HLNNEHALDD RSTAQCRVQM QVVQQLEIQL SKERERLQAM
410 420 430 440 450
MTHLHMRPSE PKPSPKPLNL VSSVTMSKNM LETSPQSLPQ TPTTPTAPVT
460 470 480 490 500
PITQGPSVIT PASVPNVGAI RRRHSDKYNI PMSSEIAPNY EFYKNADVRP
510 520 530 540 550
PFTYATLIRQ AIMESSDRQL TLNEIYSWFT RTFAYFRRNA ATWKNAVRHN
560 570 580 590 600
LSLHKCFVRV ENVKGAVWTV DEVEYQKRRS QKITGSPTLV KNIPTSLGYG
610 620 630 640 650
AALNASLQAA LAESSLPLLS NPGLINNASS GLLQAVHEDL NGSLDHIDSN
660 670 680 690 700
GNSSPGCSPQ PHIHSIHVKE EPVIAEDEDC PMSLVTTANH SPELEDDREI
710
EEEPLSEDLE
Length:710
Mass (Da):79,236
Last modified:April 20, 2010 - v1
Checksum:iCB77B7D405C4B6AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111321 Genomic DNA. No translation available.
AC128862 Genomic DNA. No translation available.
AC115440 Genomic DNA. No translation available.
AC122630 Genomic DNA. No translation available.
RefSeqiNP_001258033.1. NM_001271104.1.
UniGeneiRn.134464.

Genome annotation databases

EnsembliENSRNOT00000087146; ENSRNOP00000069190; ENSRNOG00000054508.
GeneIDi500037.
KEGGirno:500037.
UCSCiRGD:1559697. rat.

Similar proteinsi

Entry informationi

Entry nameiFOXP2_RAT
AccessioniPrimary (citable) accession number: P0CF24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: August 30, 2017
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome