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Protein

Forkhead box protein P2

Gene

Foxp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein inferred from homologyi

Functioni

Transcriptional repressor that may play a role in the specification and differentiation of lung epithelium. May also play a role in developing neural, gastrointestinal and cardiovascular tissues. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays a role in synapse formation by regulating SRPX2 levels.By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 36624C2H2-typeAdd
BLAST
DNA bindingi499 – 58991Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Forkhead box protein P2
Gene namesi
Name:Foxp2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi1559697. Foxp2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 710710Forkhead box protein P2PRO_0000393401Add
BLAST

Proteomic databases

PaxDbiP0CF24.

Expressioni

Gene expression databases

GenevisibleiP0CF24. RN.

Interactioni

Subunit structurei

Forms homodimers and heterodimers with FOXP1 and FOXP4. Dimerization is required for DNA-binding. Interacts with CTBP1. Interacts with FOXP1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007759.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni383 – 40422Leucine-zipperAdd
BLAST
Regioni417 – 4215CTBP1-bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi53 – 263211Gln-richAdd
BLAST

Domaini

The leucine-zipper is required for dimerization and transcriptional repression.By similarity

Sequence similaritiesi

Contains 1 C2H2-type zinc finger.Curated
Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri343 – 36624C2H2-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
InParanoidiP0CF24.
KOiK09409.
PhylomeDBiP0CF24.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CF24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQESATETI SNSSMNQNGM STLSSQLDAG SRDGRSSGDT SSEVSTVELL
60 70 80 90 100
HLQQQQALQA ARQLLLQQQT SGLKSPKSSD KQRPLQVPVS VAMMTPQVIT
110 120 130 140 150
PQQMQQILQQ QVLSPQQLQA LLQQQQAVML QQQQLQEFYK KQQEQLHLQL
160 170 180 190 200
LQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQHPG KQAKEQQQQQ
210 220 230 240 250
QQQQLAAQQL VFQQQLLQMQ QLQQQQHLLS LQCQGLISIP PGQAALPVQS
260 270 280 290 300
LPQAGLSPAE IQQLWKEVTG VHSQEDNGIK HGGLDLTTNN SSSTTSSTTS
310 320 330 340 350
KASPPITHHS IVNGQSSVLN ARRDSSSHEE TGASHTLYGH GVCKWPGCES
360 370 380 390 400
ICEDFGQFLK HLNNEHALDD RSTAQCRVQM QVVQQLEIQL SKERERLQAM
410 420 430 440 450
MTHLHMRPSE PKPSPKPLNL VSSVTMSKNM LETSPQSLPQ TPTTPTAPVT
460 470 480 490 500
PITQGPSVIT PASVPNVGAI RRRHSDKYNI PMSSEIAPNY EFYKNADVRP
510 520 530 540 550
PFTYATLIRQ AIMESSDRQL TLNEIYSWFT RTFAYFRRNA ATWKNAVRHN
560 570 580 590 600
LSLHKCFVRV ENVKGAVWTV DEVEYQKRRS QKITGSPTLV KNIPTSLGYG
610 620 630 640 650
AALNASLQAA LAESSLPLLS NPGLINNASS GLLQAVHEDL NGSLDHIDSN
660 670 680 690 700
GNSSPGCSPQ PHIHSIHVKE EPVIAEDEDC PMSLVTTANH SPELEDDREI
710
EEEPLSEDLE
Length:710
Mass (Da):79,236
Last modified:April 20, 2010 - v1
Checksum:iCB77B7D405C4B6AD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111321 Genomic DNA. No translation available.
AC128862 Genomic DNA. No translation available.
AC115440 Genomic DNA. No translation available.
AC122630 Genomic DNA. No translation available.
RefSeqiNP_001258033.1. NM_001271104.1.
XP_008760941.1. XM_008762719.1.
XP_008760942.1. XM_008762720.1.
UniGeneiRn.134464.

Genome annotation databases

EnsembliENSRNOT00000087146; ENSRNOP00000069190; ENSRNOG00000054508.
GeneIDi500037.
KEGGirno:500037.
UCSCiRGD:1559697. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111321 Genomic DNA. No translation available.
AC128862 Genomic DNA. No translation available.
AC115440 Genomic DNA. No translation available.
AC122630 Genomic DNA. No translation available.
RefSeqiNP_001258033.1. NM_001271104.1.
XP_008760941.1. XM_008762719.1.
XP_008760942.1. XM_008762720.1.
UniGeneiRn.134464.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000007759.

Proteomic databases

PaxDbiP0CF24.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000087146; ENSRNOP00000069190; ENSRNOG00000054508.
GeneIDi500037.
KEGGirno:500037.
UCSCiRGD:1559697. rat.

Organism-specific databases

CTDi93986.
RGDi1559697. Foxp2.

Phylogenomic databases

eggNOGiKOG4385. Eukaryota.
COG5025. LUCA.
GeneTreeiENSGT00800000124014.
InParanoidiP0CF24.
KOiK09409.
PhylomeDBiP0CF24.

Miscellaneous databases

PROiP0CF24.

Gene expression databases

GenevisibleiP0CF24. RN.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR001766. Fork_head_dom.
IPR032354. FOXP-CC.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF16159. FOXP-CC. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
    Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J., Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G., Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G., Morgan M.
    , Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G., Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S., Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T., Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D., Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L., Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D., Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M., Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C., Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J., Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H., Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X., Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q., Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P., Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A., Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C., Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J., Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J., Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F., Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A., Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A., Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J., Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E., Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M., Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C., Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L., Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W., Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y., Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V., Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M., Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S., Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B., Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R., Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J., Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D., Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S., Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S., Mockrin S., Collins F.S.
    Nature 428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  2. "The human language-associated gene SRPX2 regulates synapse formation and vocalization in mice."
    Sia G.M., Clem R.L., Huganir R.L.
    Science 342:987-991(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiFOXP2_RAT
AccessioniPrimary (citable) accession number: P0CF24
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 20, 2010
Last sequence update: April 20, 2010
Last modified: June 8, 2016
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.