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Protein

Kappa-conotoxin-like SmIVB

Gene
N/A
Organism
Conus stercusmuscarum (Fly-specked cone)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Kappa-A-conotoxins bind and inhibit voltage-gated potassium channels.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionIon channel impairing toxin, Neurotoxin, Potassium channel impairing toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Kappa-conotoxin-like SmIVB
OrganismiConus stercusmuscarum (Fly-specked cone)
Taxonomic identifieri89452 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaGastropodaCaenogastropodaHypsogastropodaNeogastropodaConoideaConidaeConus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PropeptideiPRO_000039270922 – 38By similarityAdd BLAST17
PeptideiPRO_000039271039 – 75Kappa-conotoxin-like SmIVBAdd BLAST37
PropeptideiPRO_000039271176 – 80By similarity5

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei404-hydroxyprolineBy similarity1
Glycosylationi45O-linked (HexNAc...) serineCurated1
Glycosylationi46O-linked (HexNAc...) threonineCurated1
Modified residuei554-hydroxyprolineBy similarity1
Modified residuei604-hydroxyprolineBy similarity1
Modified residuei614-hydroxyprolineBy similarity1
Modified residuei704-hydroxyprolineBy similarity1
Modified residuei724-hydroxyprolineBy similarity1
Modified residuei75Serine amideBy similarity1

Post-translational modificationi

Contains 3 disulfide bonds (By similarity). They are not added, since framework IV presents two different connectivities (I-V, II-III, IV-VI and I-III, II-V, IV-VI).By similarity

Keywords - PTMi

Amidation, Disulfide bond, Glycoprotein, Hydroxylation

Expressioni

Tissue specificityi

Expressed by the venom duct.

Structurei

3D structure databases

SMRiP0CE76.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

The cysteine framework is IV (CC-C-C-C-C).

Sequence similaritiesi

Belongs to the conotoxin A superfamily.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiView protein in InterPro
IPR009958. Conotoxin_a-typ.
PfamiView protein in Pfam
PF07365. Toxin_8. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CE76-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGMRMMFTVF LLVVLATTVV SIPSDRASDG RNAEVNERAP WLVPSTITTC
60 70 80
CGYDPGSMCP PCMCNNTCKP KPKKSGRRNH
Length:80
Mass (Da):8,778
Last modified:March 23, 2010 - v1
Checksum:i5FE60549491A0203
GO

Similar proteinsi

Entry informationi

Entry nameiCA4B_CONSE
AccessioniPrimary (citable) accession number: P0CE76
Secondary accession number(s): P0C1Y3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 22, 2017
This is version 19 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families