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Protein

Oncomodulin-1

Gene

OCM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi52Calcium 1Combined sources1 Publication1
Metal bindingi56Calcium 1Combined sources1 Publication1
Metal bindingi58Calcium 1; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi63Calcium 1Combined sources1 Publication1
Metal bindingi91Calcium 1Combined sources1 Publication1
Metal bindingi93Calcium 2Combined sources1 Publication1
Metal bindingi95Calcium 2Combined sources1 Publication1
Metal bindingi97Calcium 2; via carbonyl oxygenCombined sources1 Publication1
Metal bindingi102Calcium 2Combined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi52 – 631Combined sources1 PublicationAdd BLAST12
Calcium bindingi91 – 1022Combined sources1 PublicationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oncomodulin-1
Short name:
OM
Alternative name(s):
Parvalbumin beta
Gene namesi
Name:OCM
Synonyms:OCM1, OCMN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000122543.10
HGNCiHGNC:8105 OCM
MIMi164795 gene
neXtProtiNX_P0CE72

Pathology & Biotechi

Organism-specific databases

DisGeNETi654231
OpenTargetsiENSG00000122543
PharmGKBiPA31894

Polymorphism and mutation databases

BioMutaiOCM
DMDMi292630843

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000735822 – 109Oncomodulin-1Add BLAST108

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP0CE72
PeptideAtlasiP0CE72
PRIDEiP0CE72

PTM databases

iPTMnetiP0CE72
PhosphoSitePlusiP0CE72

Expressioni

Gene expression databases

BgeeiENSG00000122543
GenevisibleiP0CE72 HS

Organism-specific databases

HPAiHPA046422

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi576309, 1 interactor
IntActiP0CE72, 2 interactors
STRINGi9606.ENSP00000242104

Structurei

Secondary structure

1109
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni4 – 6Combined sources3
Helixi8 – 18Combined sources11
Helixi27 – 33Combined sources7
Turni36 – 38Combined sources3
Helixi41 – 51Combined sources11
Beta strandi56 – 58Combined sources3
Helixi61 – 64Combined sources4
Helixi68 – 70Combined sources3
Helixi80 – 90Combined sources11
Beta strandi92 – 96Combined sources5
Helixi100 – 108Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TTXNMR-A1-109[»]
ProteinModelPortaliP0CE72
SMRiP0CE72
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CE72

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini39 – 74EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini78 – 109EF-hand 2PROSITE-ProRule annotationAdd BLAST32

Sequence similaritiesi

Belongs to the parvalbumin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027 Eukaryota
COG5126 LUCA
GeneTreeiENSGT00390000008690
HOGENOMiHOG000037438
HOVERGENiHBG107490
InParanoidiP0CE72
OMAiNAVKDCQ
OrthoDBiEOG091G0XK0
PhylomeDBiP0CE72
TreeFamiTF332342

Family and domain databases

InterProiView protein in InterPro
IPR011992 EF-hand-dom_pair
IPR018247 EF_Hand_1_Ca_BS
IPR002048 EF_hand_dom
IPR008080 Parvalbumin
PANTHERiPTHR11653 PTHR11653, 1 hit
PfamiView protein in Pfam
PF13499 EF-hand_7, 1 hit
SMARTiView protein in SMART
SM00054 EFh, 2 hits
SUPFAMiSSF47473 SSF47473, 1 hit
PROSITEiView protein in PROSITE
PS00018 EF_HAND_1, 2 hits
PS50222 EF_HAND_2, 2 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CE72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITDVLSAD DIAAALQECR DPDTFEPQKF FQTSGLSKMS ANQVKDVFRF
60 70 80 90 100
IDNDQSGYLD EEELKFFLQK FESGARELTE SETKSLMAAA DNDGDGKIGA

EEFQEMVHS
Length:109
Mass (Da):12,184
Last modified:March 23, 2010 - v1
Checksum:iC5793E2FF4A058A0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti20R → Q in AAA02869 (PubMed:8354278).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20348
, L20345, L20346, L20347 Genomic DNA Translation: AAA02869.1
AC004983 Genomic DNA No translation available.
CH471144 Genomic DNA Translation: EAW87352.1
BC069468 mRNA Translation: AAH69468.1
BC069512 mRNA Translation: AAH69512.1
BC069550 mRNA Translation: AAH69550.1
BC113706 mRNA Translation: AAI13707.1
BC113704 mRNA Translation: AAI13705.1
BC147028 mRNA Translation: AAI47029.1
BC147029 mRNA Translation: AAI47030.1
CCDSiCCDS43548.1
PIRiS35041 PVHUO
RefSeqiNP_001091091.1, NM_001097622.1
XP_011513787.1, XM_011515485.2
UniGeneiHs.571315

Genome annotation databases

EnsembliENST00000242104; ENSP00000242104; ENSG00000122543
ENST00000416608; ENSP00000401365; ENSG00000122543
GeneIDi654231
KEGGihsa:654231
UCSCiuc003spe.5 human

Similar proteinsi

Entry informationi

Entry nameiONCO_HUMAN
AccessioniPrimary (citable) accession number: P0CE72
Secondary accession number(s): B9EJH7
, P32930, Q6ISI5, Q75MW0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: April 25, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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