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Protein

Oncomodulin-1

Gene

OCM

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has some calmodulin-like activity with respect to enzyme activation and growth regulation. Binds two calcium ions.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Calcium 1Combined sources1 Publication
Metal bindingi56 – 561Calcium 1Combined sources1 Publication
Metal bindingi58 – 581Calcium 1; via carbonyl oxygenCombined sources1 Publication
Metal bindingi63 – 631Calcium 1Combined sources1 Publication
Metal bindingi91 – 911Calcium 1Combined sources1 Publication
Metal bindingi93 – 931Calcium 2Combined sources1 Publication
Metal bindingi95 – 951Calcium 2Combined sources1 Publication
Metal bindingi97 – 971Calcium 2; via carbonyl oxygenCombined sources1 Publication
Metal bindingi102 – 1021Calcium 2Combined sources1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi52 – 63121Combined sources1 PublicationAdd
BLAST
Calcium bindingi91 – 102122Combined sources1 PublicationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oncomodulin-1
Short name:
OM
Alternative name(s):
Parvalbumin beta
Gene namesi
Name:OCM
Synonyms:OCM1, OCMN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:8105. OCM.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31894.

Polymorphism and mutation databases

BioMutaiOCM.
DMDMi292630843.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 109108Oncomodulin-1PRO_0000073582Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP0CE72.
PeptideAtlasiP0CE72.
PRIDEiP0CE72.

PTM databases

iPTMnetiP0CE72.

Expressioni

Gene expression databases

BgeeiP0CE72.
GenevisibleiP0CE72. HS.

Organism-specific databases

HPAiHPA046422.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000242104.

Structurei

Secondary structure

1
109
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni4 – 63Combined sources
Helixi8 – 1811Combined sources
Helixi27 – 337Combined sources
Turni36 – 383Combined sources
Helixi41 – 5111Combined sources
Beta strandi56 – 583Combined sources
Helixi61 – 644Combined sources
Helixi68 – 703Combined sources
Helixi80 – 9011Combined sources
Beta strandi92 – 965Combined sources
Helixi100 – 1089Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TTXNMR-A1-109[»]
ProteinModelPortaliP0CE72.
SMRiP0CE72. Positions 1-109.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP0CE72.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 7436EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 10932EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP0CE72.
OMAiAVKDCQA.
OrthoDBiEOG7TF7C9.
PhylomeDBiP0CE72.
TreeFamiTF332342.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CE72-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITDVLSAD DIAAALQECR DPDTFEPQKF FQTSGLSKMS ANQVKDVFRF
60 70 80 90 100
IDNDQSGYLD EEELKFFLQK FESGARELTE SETKSLMAAA DNDGDGKIGA

EEFQEMVHS
Length:109
Mass (Da):12,184
Last modified:March 23, 2010 - v1
Checksum:iC5793E2FF4A058A0
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti20 – 201R → Q in AAA02869 (PubMed:8354278).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20348
, L20345, L20346, L20347 Genomic DNA. Translation: AAA02869.1.
AC004983 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87352.1.
BC069468 mRNA. Translation: AAH69468.1.
BC069512 mRNA. Translation: AAH69512.1.
BC069550 mRNA. Translation: AAH69550.1.
BC113706 mRNA. Translation: AAI13707.1.
BC113704 mRNA. Translation: AAI13705.1.
BC147028 mRNA. Translation: AAI47029.1.
BC147029 mRNA. Translation: AAI47030.1.
CCDSiCCDS43548.1.
PIRiS35041. PVHUO.
RefSeqiNP_001091091.1. NM_001097622.1.
XP_011513787.1. XM_011515485.1.
UniGeneiHs.571315.

Genome annotation databases

EnsembliENST00000242104; ENSP00000242104; ENSG00000122543.
ENST00000416608; ENSP00000401365; ENSG00000122543.
GeneIDi654231.
KEGGihsa:654231.
UCSCiuc003spe.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L20348
, L20345, L20346, L20347 Genomic DNA. Translation: AAA02869.1.
AC004983 Genomic DNA. No translation available.
CH471144 Genomic DNA. Translation: EAW87352.1.
BC069468 mRNA. Translation: AAH69468.1.
BC069512 mRNA. Translation: AAH69512.1.
BC069550 mRNA. Translation: AAH69550.1.
BC113706 mRNA. Translation: AAI13707.1.
BC113704 mRNA. Translation: AAI13705.1.
BC147028 mRNA. Translation: AAI47029.1.
BC147029 mRNA. Translation: AAI47030.1.
CCDSiCCDS43548.1.
PIRiS35041. PVHUO.
RefSeqiNP_001091091.1. NM_001097622.1.
XP_011513787.1. XM_011515485.1.
UniGeneiHs.571315.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1TTXNMR-A1-109[»]
ProteinModelPortaliP0CE72.
SMRiP0CE72. Positions 1-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000242104.

PTM databases

iPTMnetiP0CE72.

Polymorphism and mutation databases

BioMutaiOCM.
DMDMi292630843.

Proteomic databases

PaxDbiP0CE72.
PeptideAtlasiP0CE72.
PRIDEiP0CE72.

Protocols and materials databases

DNASUi654231.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000242104; ENSP00000242104; ENSG00000122543.
ENST00000416608; ENSP00000401365; ENSG00000122543.
GeneIDi654231.
KEGGihsa:654231.
UCSCiuc003spe.5. human.

Organism-specific databases

CTDi654231.
GeneCardsiOCM.
HGNCiHGNC:8105. OCM.
HPAiHPA046422.
MIMi164795. gene.
neXtProtiNX_P0CE72.
PharmGKBiPA31894.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
HOVERGENiHBG107490.
InParanoidiP0CE72.
OMAiAVKDCQA.
OrthoDBiEOG7TF7C9.
PhylomeDBiP0CE72.
TreeFamiTF332342.

Miscellaneous databases

EvolutionaryTraceiP0CE72.
GenomeRNAii654231.
PROiP0CE72.
SOURCEiSearch...

Gene expression databases

BgeeiP0CE72.
GenevisibleiP0CE72. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Placenta.
  2. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. "Solution structure of human beta-parvalbumin and structural comparison with its paralog alpha-parvalbumin and with their rat orthologs."
    Babini E., Bertini I., Capozzi F., Del Bianco C., Hollender D., Kiss T., Luchinat C., Quattrone A.
    Biochemistry 43:16076-16085(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR, CALCIUM-BINDING SITES.

Entry informationi

Entry nameiONCO_HUMAN
AccessioniPrimary (citable) accession number: P0CE72
Secondary accession number(s): B9EJH7
, P32930, Q6ISI5, Q75MW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: July 6, 2016
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.