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Protein

Putative oncomodulin-2

Gene

OCM2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi52 – 521Calcium 1By similarity
Metal bindingi56 – 561Calcium 1By similarity
Metal bindingi58 – 581Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi63 – 631Calcium 1By similarity
Metal bindingi91 – 911Calcium 1By similarity
Metal bindingi93 – 931Calcium 2By similarity
Metal bindingi95 – 951Calcium 2By similarity
Metal bindingi97 – 971Calcium 2; via carbonyl oxygenBy similarity
Metal bindingi102 – 1021Calcium 2By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi52 – 63121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi91 – 102122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • calcium ion binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative oncomodulin-2
Gene namesi
Name:OCM2
Synonyms:OCMN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:34396. OCM2.

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA164724233.

Polymorphism and mutation databases

BioMutaiOCM2.
DMDMi292630842.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 109108Putative oncomodulin-2PRO_0000392643Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP0CE71.
PRIDEiP0CE71.

Expressioni

Gene expression databases

BgeeiP0CE71.
GenevisibleiP0CE71. HS.

Organism-specific databases

HPAiHPA046422.

Interactioni

Protein-protein interaction databases

BioGridi111005. 3 interactions.
IntActiP0CE71. 3 interactions.
STRINGi9606.ENSP00000257627.

Structurei

3D structure databases

ProteinModelPortaliP0CE71.
SMRiP0CE71. Positions 1-109.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini39 – 7436EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini78 – 10932EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the parvalbumin family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
InParanoidiP0CE71.
OMAiKFFETSG.
OrthoDBiEOG7TF7C9.
PhylomeDBiP0CE71.
TreeFamiTF332342.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P0CE71-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSITDVLSAD DIAAALQECQ DPDTFEPQKF FQTSGLSKMS ASQVKDVFRF
60 70 80 90 100
IDNDQSGYLD EEELKFFLQK FESGARELTE SETKSLMAAA DNDGDGKIGA

EEFQEMVHS
Length:109
Mass (Da):12,129
Last modified:March 23, 2010 - v1
Checksum:i5C7A0D3D25634A72
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004967 Genomic DNA. Translation: AAQ96880.1.
CCDSiCCDS5653.1.
RefSeqiNP_006179.2. NM_006188.3.
UniGeneiHs.510456.

Genome annotation databases

EnsembliENST00000257627; ENSP00000257627; ENSG00000135175.
GeneIDi4951.
KEGGihsa:4951.
UCSCiuc003upc.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC004967 Genomic DNA. Translation: AAQ96880.1.
CCDSiCCDS5653.1.
RefSeqiNP_006179.2. NM_006188.3.
UniGeneiHs.510456.

3D structure databases

ProteinModelPortaliP0CE71.
SMRiP0CE71. Positions 1-109.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111005. 3 interactions.
IntActiP0CE71. 3 interactions.
STRINGi9606.ENSP00000257627.

Polymorphism and mutation databases

BioMutaiOCM2.
DMDMi292630842.

Proteomic databases

PaxDbiP0CE71.
PRIDEiP0CE71.

Protocols and materials databases

DNASUi4951.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000257627; ENSP00000257627; ENSG00000135175.
GeneIDi4951.
KEGGihsa:4951.
UCSCiuc003upc.4. human.

Organism-specific databases

CTDi4951.
GeneCardsiOCM2.
HGNCiHGNC:34396. OCM2.
HPAiHPA046422.
neXtProtiNX_P0CE71.
PharmGKBiPA164724233.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0027. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00390000008690.
HOGENOMiHOG000037438.
InParanoidiP0CE71.
OMAiKFFETSG.
OrthoDBiEOG7TF7C9.
PhylomeDBiP0CE71.
TreeFamiTF332342.

Miscellaneous databases

GeneWikiiLOC4951.
GenomeRNAii4951.
NextBioi19071.

Gene expression databases

BgeeiP0CE71.
GenevisibleiP0CE71. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR008080. Parvalbumin.
[Graphical view]
PANTHERiPTHR11653. PTHR11653. 1 hit.
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 2 hits.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiOCM2_HUMAN
AccessioniPrimary (citable) accession number: P0CE71
Secondary accession number(s): P32930, Q6ISI5, Q75MW0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: March 16, 2016
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.