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Protein

ABC transporter NFT1

Gene

NFT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi686 – 693ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

  • macroautophagy Source: SGD
  • transport Source: SGD

Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32065-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
ABC transporter NFT1
Alternative name(s):
New full-length MRP-type transporter 1
Gene namesi
Name:NFT1
Ordered Locus Names:YKR103W
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XI

Organism-specific databases

EuPathDBiFungiDB:YKR103W.
SGDiS000001811. NFT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini51 – 103CytoplasmicSequence analysisAdd BLAST53
Transmembranei104 – 124HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini125 – 130ExtracellularSequence analysis6
Transmembranei131 – 151HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini152 – 169CytoplasmicSequence analysisAdd BLAST18
Transmembranei170 – 190HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini191 – 201ExtracellularSequence analysisAdd BLAST11
Transmembranei202 – 222HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini223 – 302CytoplasmicSequence analysisAdd BLAST80
Transmembranei303 – 323HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini324 – 351ExtracellularSequence analysisAdd BLAST28
Transmembranei352 – 374HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini375 – 449CytoplasmicSequence analysisAdd BLAST75
Transmembranei450 – 470HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini471 – 481ExtracellularSequence analysisAdd BLAST11
Transmembranei482 – 504HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini505 – 558CytoplasmicSequence analysisAdd BLAST54
Transmembranei559 – 579HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini580 – 584ExtracellularSequence analysis5
Transmembranei585 – 605HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini606 – 953CytoplasmicSequence analysisAdd BLAST348
Transmembranei954 – 974HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini975 – 1013ExtracellularSequence analysisAdd BLAST39
Transmembranei1014 – 1034HelicalPROSITE-ProRule annotationAdd BLAST21
Topological domaini1035 – 1082CytoplasmicSequence analysisAdd BLAST48
Transmembranei1083 – 1105HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini1106 – 1109ExtracellularSequence analysis4
Transmembranei1110 – 1132HelicalPROSITE-ProRule annotationAdd BLAST23
Topological domaini1133 – 1197CytoplasmicSequence analysisAdd BLAST65
Transmembranei1198 – 1218HelicalPROSITE-ProRule annotationAdd BLAST21

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934621 – 1218ABC transporter NFT1Add BLAST1218

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PRIDEiP0CE68.

PTM databases

iPTMnetiP0CE68.

Interactioni

Protein-protein interaction databases

BioGridi34234. 79 interactors.
STRINGi4932.YKR103W.

Structurei

3D structure databases

ProteinModelPortaliP0CE68.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini311 – 621ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST311
Domaini651 – 892ABC transporterPROSITE-ProRule annotationAdd BLAST242
Domaini961 – 1218ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST258

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00890000140109.
InParanoidiP0CE68.
OrthoDBiEOG092C0VET.

Family and domain databases

InterProiView protein in InterPro
IPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
PfamiView protein in Pfam
PF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 1 hit.
SMARTiView protein in SMART
SM00382. AAA. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF90123. SSF90123. 3 hits.
PROSITEiView protein in PROSITE
PS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.

Sequencei

Sequence statusi: Complete.

P0CE68-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKNGTCPYW ERDDLSECAR REYIEFKFPL FILLTGMIYA FCKVFRAFYL
60 70 80 90 100
RGKNHTNEAP EFEEQGNGNH EYARFSVLRL KSAWESRSFC NVNNRSTFDK
110 120 130 140 150
FKKFIEGAFI VLQLTIHLYI LSSMPMDNKK FFHQGFLVQM FLWILLLVVI
160 170 180 190 200
TLRLISASQS FRWVLACKRD LWAVSFYSYA SLFTLSILPL RSVFIGKIKD
210 220 230 240 250
KIMVKYIISE TFIDLALLLL LSTSSIEGTR YSFLVENENK KLPPAPTVFG
260 270 280 290 300
LLTFSRIDRL IWKAYKHCLG NADIWDLDIN NKSIAILANF EMSSKKGRLL
310 320 330 340 350
PNIICYFKAV FISQLFLAFV SSFLNFVPSL LMPRILSYVN DPKSKSWNLV
360 370 380 390 400
SLYVSSMLVS KIIATTCRGQ GLFLGEKGTM QLRTVLISNI YSKTLRRTIL
410 420 430 440 450
KDSTTSLQKN ASTSFEENPD SSEAEPRKKS SRKDNSVNNV MSIDAFKVSE
460 470 480 490 500
AMNTFYLACE AVFMTVTALM ILYSLLGWSA FAGTFALLAM IPLNFWCATF
510 520 530 540 550
YGNYQADQLI LTDKRTSGIS EALNSIRVIK LLAWENLFYQ KIINVRDGEI
560 570 580 590 600
RLLKKKATIF FLNHLIWFFG PTLVSAITFS VFIKFQNQTL TPTIAFTALS
610 620 630 640 650
LFAILRTPMD QIASTVSLLI QSFISLERIQ DYLNESETRK YEILEQSNTK
660 670 680 690 700
FGFEDASMEW EAAETSFKLK NISIDFKLNS LNAIIGPTGS GKSSLLLGLL
710 720 730 740 750
GELNLLSGKI YVPTVESRDD LEIGKDGMTN SMAYCSQTPW LISGTIKDNV
760 770 780 790 800
VFGEIFNKQK FDDVMKSCCL DKDIKAMTAG IRTDVGDGGF SLSGGQQQRI
810 820 830 840 850
ALARAIYSSS RYLILDDCLS AVDPETALYI YEECLCGPMM KGRTCIITSH
860 870 880 890 900
NISLVTKRAD WLVILDRGEV KSQGKPSDLI KSNEFLRESI NNDSKNTTHN
910 920 930 940 950
QIDLKRSTTS KKTKNGDPEG GNSQDEVCAE VENFEETKME GSVKFSAYKW
960 970 980 990 1000
LADYFGGLGV VFVFTSSSIL IHGITLSQGF WLRYWLDTGS SGSKSTWLYR
1010 1020 1030 1040 1050
IVEGHSNIYF LLTYIIIGLV SSFLTSGKVW IAIISGTNVT KKIFAKLLSS
1060 1070 1080 1090 1100
ILYAKLRFHN VTPTGRIMNR FSKDMDIIDQ QLIPNFEGLS YSVVVCLWII
1110 1120 1130 1140 1150
LLIGYVTPQF LLFAIPLCAL YYTVCTLYLR ASRELKRIDN INISPIHQLF
1160 1170 1180 1190 1200
AEAIKGVTTI RALADERRFI TQSLVAIDRS NAPFFYLNMA TEWITYRVDI
1210
IGTLVLFSSS VMIIMKAS
Length:1,218
Mass (Da):137,997
Last modified:March 23, 2010 - v1
Checksum:i804810FD5BF0C210
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z28328 Genomic DNA. Translation: CAA82183.1.
BK006944 Genomic DNA. Translation: DAA09254.1.
PIRiS38182.
RefSeqiNP_013029.3. NM_001179893.3.

Genome annotation databases

EnsemblFungiiYKR103W; YKR103W; YKR103W.
GeneIDi853978.
KEGGisce:YKR103W.

Similar proteinsi

Entry informationi

Entry nameiNFT1_YEAST
AccessioniPrimary (citable) accession number: P0CE68
Secondary accession number(s): D6VXG4
, P36028, P36171, Q53ZY4, Q6Q5L3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: August 30, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Caution

This is a truncated version of the ABC transporter NFT1. S288c has a stop codon in position 1219, which disrupts the gene coding for this protein and produces two ORFs YKR103W and YKR104W. A contiguous sequence for ABC transporter NFT1 can be found in strains Sigma 1278B, EG123 and SK1 (AC P0CE70).Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XI
    Yeast (Saccharomyces cerevisiae) chromosome XI: entries and gene names