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Protein

Glucuronide carrier protein

Gene

uidB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Responsible for the transport of glucuronide into the cell energized by the proton motive force (probably by symport). Import is enhanced by UidC (GusC, AC Q47706).

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Sugar transport, Symport, Transport

Protein family/group databases

TCDBi2.A.2.3.1. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucuronide carrier protein
Alternative name(s):
Glucuronide permease
Gene namesi
Name:uidB
Synonyms:gusB, uidP
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Topological domaini35 – 37PeriplasmicSequence analysis3
Transmembranei38 – 60HelicalSequence analysisAdd BLAST23
Topological domaini61 – 79CytoplasmicSequence analysisAdd BLAST19
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 108PeriplasmicSequence analysis8
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 180PeriplasmicSequence analysisAdd BLAST13
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 228CytoplasmicSequence analysisAdd BLAST27
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 263PeriplasmicSequence analysisAdd BLAST14
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 296CytoplasmicSequence analysisAdd BLAST12
Transmembranei297 – 316HelicalSequence analysisAdd BLAST20
Topological domaini317 – 320PeriplasmicSequence analysis4
Transmembranei321 – 343HelicalSequence analysisAdd BLAST23
Topological domaini344 – 372CytoplasmicSequence analysisAdd BLAST29
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 408PeriplasmicSequence analysisAdd BLAST15
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Topological domaini430 – 457CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003922051 – 457Glucuronide carrier proteinAdd BLAST457

Proteomic databases

PaxDbiP0CE45.

Expressioni

Inductioni

In the presence of glucuronides.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi511145.b1616.

Structurei

3D structure databases

ProteinModelPortaliP0CE45.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CT4. Bacteria.
COG2211. LUCA.
HOGENOMiHOG000222021.
OMAiAWISSIV.
PhylomeDBiP0CE45.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR001927. Na/Gal_symport.
IPR018043. Na/Gal_symport_CS.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00792. gph. 1 hit.
PROSITEiPS00872. NA_GALACTOSIDE_SYMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P0CE45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQQLSWRTI VGYSLGDVAN NFAFAMGALF LLSYYTDVAG VGAAAAGTML
60 70 80 90 100
LLVRVFDAFA DVFAGRVVDS VNTRWGKFRP FLLFGTAPLM IFSVLVFWVP
110 120 130 140 150
TDWSHGSKVV YAYLTYMGLG LCYSLVNIPY GSLATAMTQQ PQSRARLGAA
160 170 180 190 200
RGIAASLTFV CLAFLIGPSI KNSSPEEMVS VYHFWTIVLA IAGMVLYFIC
210 220 230 240 250
FKSTRENVVR IVAQPSLNIS LQTLKRNRPL FMLCIGALCV LISTFAVSAS
260 270 280 290 300
SLFYVRYVLN DTGLFTVLVL VQNLVGTVAS APLVPGMVAR IGKKNTFLIG
310 320 330 340 350
ALLGTCGYLL FFWVSVWSLP VALVALAIAS IGQGVTMTVM WALEADTVEY
360 370 380 390 400
GEYLTGVRIE GLTYSLFSFT RKCGQAIGGS IPAFILGLSG YIANQVQTPE
410 420 430 440 450
VIMGIRTSIA LVPCGFMLLA FVIIWFYPLT DKKFKEIVVE IDNRKKVQQQ

LISDITN
Length:457
Mass (Da):49,892
Last modified:March 23, 2010 - v1
Checksum:iC47CCB538AC088C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14641 Genomic DNA. Translation: AAA68924.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14641 Genomic DNA. Translation: AAA68924.1.

3D structure databases

ProteinModelPortaliP0CE45.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi511145.b1616.

Protein family/group databases

TCDBi2.A.2.3.1. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Proteomic databases

PaxDbiP0CE45.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

eggNOGiENOG4105CT4. Bacteria.
COG2211. LUCA.
HOGENOMiHOG000222021.
OMAiAWISSIV.
PhylomeDBiP0CE45.

Miscellaneous databases

PROiP0CE45.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR001927. Na/Gal_symport.
IPR018043. Na/Gal_symport_CS.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00792. gph. 1 hit.
PROSITEiPS00872. NA_GALACTOSIDE_SYMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiUIDB2_ECOLI
AccessioniPrimary (citable) accession number: P0CE45
Secondary accession number(s): P30868, P77457
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: November 2, 2016
This is version 25 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

In some K12 strains, the protein is inactive for transport, probably due to a mutation at position 100.

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.