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Protein

Glucuronide carrier protein

Gene

uidB

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Responsible for the transport of glucuronide into the cell energized by the proton motive force (probably by symport). Import is enhanced by UidC (GusC, AC Q47706).

Miscellaneous

In some K12 strains, the protein is inactive for transport, probably due to a mutation at position 100.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processSugar transport, Symport, Transport

Protein family/group databases

TCDBi2.A.2.3.1 the glycoside-pentoside-hexuronide (gph):cation symporter family

Names & Taxonomyi

Protein namesi
Recommended name:
Glucuronide carrier protein
Alternative name(s):
Glucuronide permease
Gene namesi
Name:uidB
Synonyms:gusB, uidP
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 11CytoplasmicSequence analysisAdd BLAST11
Transmembranei12 – 34HelicalSequence analysisAdd BLAST23
Topological domaini35 – 37PeriplasmicSequence analysis3
Transmembranei38 – 60HelicalSequence analysisAdd BLAST23
Topological domaini61 – 79CytoplasmicSequence analysisAdd BLAST19
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Topological domaini101 – 108PeriplasmicSequence analysis8
Transmembranei109 – 129HelicalSequence analysisAdd BLAST21
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168 – 180PeriplasmicSequence analysisAdd BLAST13
Transmembranei181 – 201HelicalSequence analysisAdd BLAST21
Topological domaini202 – 228CytoplasmicSequence analysisAdd BLAST27
Transmembranei229 – 249HelicalSequence analysisAdd BLAST21
Topological domaini250 – 263PeriplasmicSequence analysisAdd BLAST14
Transmembranei264 – 284HelicalSequence analysisAdd BLAST21
Topological domaini285 – 296CytoplasmicSequence analysisAdd BLAST12
Transmembranei297 – 316HelicalSequence analysisAdd BLAST20
Topological domaini317 – 320PeriplasmicSequence analysis4
Transmembranei321 – 343HelicalSequence analysisAdd BLAST23
Topological domaini344 – 372CytoplasmicSequence analysisAdd BLAST29
Transmembranei373 – 393HelicalSequence analysisAdd BLAST21
Topological domaini394 – 408PeriplasmicSequence analysisAdd BLAST15
Transmembranei409 – 429HelicalSequence analysisAdd BLAST21
Topological domaini430 – 457CytoplasmicSequence analysisAdd BLAST28

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003922051 – 457Glucuronide carrier proteinAdd BLAST457

Proteomic databases

PRIDEiP0CE45

Expressioni

Inductioni

In the presence of glucuronides.1 Publication

Structurei

3D structure databases

ProteinModelPortaliP0CE45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CT4 Bacteria
COG2211 LUCA
HOGENOMiHOG000222021
OMAiRYVSGMI
PhylomeDBiP0CE45

Family and domain databases

InterProiView protein in InterPro
IPR036259 MFS_trans_sf
IPR001927 Na/Gal_symport
IPR018043 Na/Gal_symport_CS
SUPFAMiSSF103473 SSF103473, 1 hit
TIGRFAMsiTIGR00792 gph, 1 hit
PROSITEiView protein in PROSITE
PS00872 NA_GALACTOSIDE_SYMP, 1 hit

Sequencei

Sequence statusi: Complete.

P0CE45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQQLSWRTI VGYSLGDVAN NFAFAMGALF LLSYYTDVAG VGAAAAGTML
60 70 80 90 100
LLVRVFDAFA DVFAGRVVDS VNTRWGKFRP FLLFGTAPLM IFSVLVFWVP
110 120 130 140 150
TDWSHGSKVV YAYLTYMGLG LCYSLVNIPY GSLATAMTQQ PQSRARLGAA
160 170 180 190 200
RGIAASLTFV CLAFLIGPSI KNSSPEEMVS VYHFWTIVLA IAGMVLYFIC
210 220 230 240 250
FKSTRENVVR IVAQPSLNIS LQTLKRNRPL FMLCIGALCV LISTFAVSAS
260 270 280 290 300
SLFYVRYVLN DTGLFTVLVL VQNLVGTVAS APLVPGMVAR IGKKNTFLIG
310 320 330 340 350
ALLGTCGYLL FFWVSVWSLP VALVALAIAS IGQGVTMTVM WALEADTVEY
360 370 380 390 400
GEYLTGVRIE GLTYSLFSFT RKCGQAIGGS IPAFILGLSG YIANQVQTPE
410 420 430 440 450
VIMGIRTSIA LVPCGFMLLA FVIIWFYPLT DKKFKEIVVE IDNRKKVQQQ

LISDITN
Length:457
Mass (Da):49,892
Last modified:March 23, 2010 - v1
Checksum:iC47CCB538AC088C1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M14641 Genomic DNA Translation: AAA68924.1

Similar proteinsi

Entry informationi

Entry nameiUIDB2_ECOLI
AccessioniPrimary (citable) accession number: P0CE45
Secondary accession number(s): P30868, P77457
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 23, 2010
Last sequence update: March 23, 2010
Last modified: May 23, 2018
This is version 31 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

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